(Q44196009)

30 November 2017

title

Leptin expression in hypothalamic PVN reverses dietary obesity and hyperinsulinemia but stimulates ghrelin (English)

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30 November 2017

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Michela Bagnasco

1

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30 November 2017

Michael G Dube

2

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30 November 2017

Adi Katz

3

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30 November 2017

Pushpa S Kalra

4

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30 November 2017

Satya P Kalra

5

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30 November 2017

publication date

1 December 2003

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30 November 2017

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30 November 2017

volume

11

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30 November 2017

issue

12

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30 November 2017

page(s)

1463-1470

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Obesity and the regulation of energy balance

30 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.196

Leptin regulation of neuroendocrine systems

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Serum immunoreactive-leptin concentrations in normal-weight and obese humans

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Dynamic regulation of leptin entry into brain by the blood-brain barrier

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Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats

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Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

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Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study

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Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus

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Long-term suppression of weight gain, adiposity, and serum insulin by central leptin gene therapy in prepubertal rats: effects on serum ghrelin and appetite-regulating genes

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Evidence for the existence of distinct central appetite, energy expenditure, and ghrelin stimulation pathways as revealed by hypothalamic site-specific leptin gene therapy

21 January 2018

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Central leptin gene therapy blocks high-fat diet-induced weight gain, hyperleptinemia, and hyperinsulinemia: increase in serum ghrelin levels

21 January 2018

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Leptin receptors in estrogen receptor-containing neurons of the female rat hypothalamus

21 January 2018

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Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization

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Unraveling the central nervous system pathways underlying responses to leptin

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The long form of the leptin receptor (OB-Rb) is widely expressed in the human brain

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Neural substrates for leptin and neuropeptide Y (NPY) interaction: hypothalamic sites associated with inhibition of NPY-induced food intake

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A war on obesity, not the obese

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Effects of the obese gene product on body weight regulation in ob/ob mice

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Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice. Relationship with body weight change

21 January 2018

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Leptin gene expression in the brain and pituitary gland

21 January 2018

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Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake

21 January 2018

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Brain stem is a direct target for leptin's action in the central nervous system

21 January 2018

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Neuropeptide Y (NPY) Y1 receptor mRNA is upregulated in association with transient hyperphagia and body weight gain: evidence for a hypothalamic site for concurrent development of leptin resistance

21 January 2018

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Disruption in neuropeptide Y and leptin signaling in obese ventromedial hypothalamic-lesioned rats

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Resistance to adenovirally induced hyperleptinemia in rats. Comparison of ventromedial hypothalamic lesions and mutated leptin receptors

21 January 2018

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Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics

21 January 2018

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Real-time single-molecule imaging of the infection pathway of an adeno-associated virus

21 January 2018

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Obesity and insulin resistance

21 January 2018

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https://api.crossref.org/works/10.1038%2FOBY.2003.196

Ghrelin induces adiposity in rodents

21 January 2018

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https://api.crossref.org/works/10.1038%2FOBY.2003.196

Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.196

The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis

21 January 2018

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https://api.crossref.org/works/10.1038%2FOBY.2003.196

Obesity and the environment: where do we go from here?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.196

A clinical view of the obesity problem

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.196

Regulation of leptin secretion: effects of aging on daily patterns of serum leptin and food consumption

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.196

Impaired transport of leptin across the blood-brain barrier in obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.196

Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.196

Towards a molecular understanding of adaptive thermogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.196

Neuropeptide Y injection into the fourth cerebroventricle stimulates c-Fos expression in the paraventricular nucleus and other nuclei in the forebrain: effect of food consumption

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.196

c-fos expression in the rat brain following central administration of neuropeptide Y and effects of food consumption

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.196

The adipoinsular axis: effects of leptin on pancreatic beta-cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.196

Minireview: ghrelin and the regulation of energy balance--a hypothalamic perspective

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2003.196

31 March 2020

Identifiers

DOI

10.1038/OBY.2003.196

1 reference

30 November 2017

1 reference