(Q37826781)

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Regulation of tyrosine kinase B activity by the Cyp46/cholesterol loss pathway in mature hippocampal neurons: relevance for neuronal survival under stress and in aging

scientific article published on 07 January 2011

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scholarly article

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Europe PubMed Central

PubMed publication ID

23 August 2017

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Europe PubMed Central

Regulation of tyrosine kinase B activity by the Cyp46/cholesterol loss pathway in mature hippocampal neurons: relevance for neuronal survival under stress and in aging (English)

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

Paul P Van Veldhoven

4

object named as

Paul Van Veldhoven

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Europe PubMed Central

PubMed publication ID

23 August 2017

author name string

Alejandro O Sodero

1

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

Laura Trovò

2

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Europe PubMed Central

PubMed publication ID

23 August 2017

Francesca Iannilli

3

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

Carlos G Dotti

5

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Europe PubMed Central

PubMed publication ID

23 August 2017

Mauricio G Martin

6

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Europe PubMed Central

PubMed publication ID

23 August 2017

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publication date

7 January 2011

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Europe PubMed Central

PubMed publication ID

23 August 2017

number of pages

9

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inferred from page(s)

Journal of Neurochemistry

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Europe PubMed Central

PubMed publication ID

23 August 2017

116

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Europe PubMed Central

PubMed publication ID

23 August 2017

5

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Europe PubMed Central

PubMed publication ID

23 August 2017

747-755

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

Neuronal membrane cholesterol loss enhances amyloid peptide generation

1 reference

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The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

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24(S),25-epoxycholesterol--a potential friend.

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Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro.

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From brain to bile. Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

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Neurotrophin-mediated rapid signaling in the central nervous system: mechanisms and functions

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On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells

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Intronic CYP46 polymorphism along with ApoE genotype in sporadic Alzheimer Disease: from risk factors to disease modulators

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NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

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Cortical injury increases cholesterol 24S hydroxylase (Cyp46) levels in the rat brain.

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Neurotrophin regulation of the developing nervous system: analyses of knockout mice

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Genetic variation in the cholesterol 24-hydroxylase (CYP46) gene and the risk of Alzheimer's disease

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Cholesterol metabolism in the brain

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GM1 ganglioside induces phosphorylation and activation of Trk and Erk in brain

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A rapid Percoll gradient procedure for preparation of synaptosomes.

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Mice lacking brain-derived neurotrophic factor develop with sensory deficits

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Neocortical neurons lacking the protein-tyrosine kinase B receptor display abnormal differentiation and process elongation in vitro and in vivo.

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BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signaling events

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Nox4-dependent H2O2 production contributes to chronic glutamate toxicity in primary cortical neurons.

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Lipid rafts and membrane traffic

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Truncated TrkB receptor-induced outgrowth of dendritic filopodia involves the p75 neurotrophin receptor

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Brain-derived neurotrophic factor, phosphorylated cyclic AMP response element binding protein and neuropeptide Y decline as early as middle age in the dentate gyrus and CA1 and CA3 subfields of the hippocampus.

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A brief history of the mortality and immortality of cultured cells

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Analysis of pyramidal neuron morphology in an inducible knockout of brain-derived neurotrophic factor

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Oxidative stress activates the pro-survival TrkA pathway through membrane cholesterol loss.

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Lipid rafts: at a crossroad between cell biology and physics.

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Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development.

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Culturing hippocampal neurons

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Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro

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Neurotrophin signal transduction in the nervous system

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Age-related changes in levels of brain-derived neurotrophic factor in selected brain regions of rats, normal mice and senescence-accelerated mice: a comparison to those of nerve growth factor and neurotrophin-3.

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Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease

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Brain cholesterol turnover required for geranylgeraniol production and learning in mice

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Gangliosides in the human brain development and aging

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Application of long-term cultured neurons in aging and neurological research: aluminum neurotoxicity, synaptic degeneration and Alzheimer's disease

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Raft disorganization leads to reduced plasmin activity in Alzheimer's disease brains

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Activation of Trk neurotrophin receptors in the absence of neurotrophins

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Carbon monoxide produced by heme oxygenase-1 in response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 signaling

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Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol

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TrkB has a cell-autonomous role in the establishment of hippocampal Schaffer collateral synapses.

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cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

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Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

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Cell-autonomous TrkB signaling in presynaptic retinal ganglion cells mediates axon arbor growth and synapse maturation during the establishment of retinotectal synaptic connectivity

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Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro

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Cyp46-mediated cholesterol loss promotes survival in stressed hippocampal neurons.

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Inhibition by compactin demonstrates a requirement of isoprenoid metabolism for long-term potentiation in rat hippocampal slices

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Stress and hippocampal plasticity

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Physiology and neurobiology of stress and adaptation: central role of the brain

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Life and death of neurons in the aging brain

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Rapid preparation of synaptosomes from mammalian brain using nontoxic isoosmotic gradient material (Percoll).

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Increased membrane cholesterol might render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity

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Identifying optimal lipid raft characteristics required to promote nanoscale protein-protein interactions on the plasma membrane

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Cholesterol level of lipid raft microdomains regulates apoptotic cell death in prostate cancer cells through EGFR-mediated Akt and ERK signal transduction.

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Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes

1 reference

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Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism

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The tyrosine kinase Fyn determines the localization of TrkB receptors in lipid rafts.

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Expression of cholesterol homeostasis genes in the brain of the male rat is affected by age and dietary restriction

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Changes in the lipid turnover, composition, and organization, as sphingolipid-enriched membrane domains, in rat cerebellar granule cells developing in vitro

1 reference

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Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain

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Lipid rafts and signal transduction

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Lipid compositions of different regions of the human brain during aging.

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Cellular stress from excitatory neurotransmission contributes to cholesterol loss in hippocampal neurons aging in vitro

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Genetic evidence for selective neurotrophin 3 signalling through TrkC but not TrkB in vivo

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Membrane lipids in the aging human brain.

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Changes in weight and compositions of major membrane components of human brain during the span of adult human life of Swedes

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24S-hydroxycholesterol in relation to disease manifestations of acute experimental autoimmune encephalomyelitis

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Cholesterol synthesis rate in human hippocampus declines with aging.

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Highest trkB mRNA expression in the entorhinal cortex among hippocampal subregions in the adult rat: contrasting pattern with BDNF mRNA expression.

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Enzymatic quantitation of cholesterol esters in lipid extracts.

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Polymorphisms of cholesterol metabolism genes CYP46 and ABCA1 and the risk of sporadic Alzheimer's disease in Chinese

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HSP90 and the chaperoning of cancer

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Recent advances in brain cholesterol dynamics: transport, domains, and Alzheimer's disease

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Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid beta-protein fibrillogenesis.

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Influences of neurotrophins on mammalian motoneurons in vivo

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p75 Co-receptors regulate ligand-dependent and ligand-independent Trk receptor activation, in part by altering Trk docking subdomains.

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Identifiers

10.1111/J.1471-4159.2010.07079.X

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

ResearchGate publication ID

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