(Q37827155)

23 August 2017

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title

Gene therapy for pulmonary hypertension: prospects and challenges (English)

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23 August 2017

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arterial hypertension

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pulmonary hypertension

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Paul N Reynolds

1

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23 August 2017

language of work or name

English

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publication date

1 February 2011

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Expert Opinion on Biological Therapy

23 August 2017

published in

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23 August 2017

volume

11

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23 August 2017

issue

2

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23 August 2017

page(s)

133-143

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Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension

23 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Pathology of pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Diagnosis and assessment of pulmonary arterial hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Updated clinical classification of pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Pulmonary arterial hypertension in France: results from a national registry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Long-term response to calcium channel blockers in idiopathic pulmonary arterial hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Updated evidence-based treatment algorithm in pulmonary arterial hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Survival with first-line bosentan in patients with primary pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Sildenafil citrate therapy for pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Inhaled iloprost for severe pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Predicting survival in pulmonary arterial hypertension: insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Imatinib in pulmonary arterial hypertension patients with inadequate response to established therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Riociguat for chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension: a phase II study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Genetics and genomics of pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

TGF-beta and BMPR-II pharmacology--implications for pulmonary vascular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Altered bone morphogenetic protein and transforming growth factor-beta signaling in rat models of pulmonary hypertension: potential for activin receptor-like kinase-5 inhibition in prevention and progression of disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Clinical outcomes of pulmonary arterial hypertension in carriers of BMPR2 mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

BMP signaling in vascular development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Gene transfer of human prostacyclin synthase ameliorates monocrotaline-induced pulmonary hypertension in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

High-efficiency gene transfer mediated by adenovirus-polylysine-DNA complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Adenovirus serotype 5 hexon mediates liver gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Combinatorial ligand-directed lung targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

A targetable, injectable adenoviral vector for selective gene delivery to pulmonary endothelium in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Selective induction of tumor-associated antigens in murine pulmonary vasculature using double-targeted adenoviral vectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

In vivo analysis of a genetically modified adenoviral vector targeted to human CD40 using a novel transient transgenic model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Analysis of cell-specific promoters for viral gene therapy targeted at the vascular endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Combined transductional and transcriptional targeting improves the specificity of transgene expression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Overexpression of human bone morphogenetic protein receptor 2 does not ameliorate monocrotaline pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Retargeting the coxsackievirus and adenovirus receptor to the apical surface of polarized epithelial cells reveals the glycocalyx as a barrier to adenovirus-mediated gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Cystic fibrosis gene therapy: successes, failures and hopes for the future

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Repeated gene transfer of naked prostacyclin synthase plasmid into skeletal muscles attenuates monocrotaline-induced pulmonary hypertension and prolongs survival in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Gene transfer of human prostacyclin synthase into the liver is effective for the treatment of pulmonary hypertension in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Genotoxicity of retroviral integration in hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Insertional mutagenesis and development of malignancies induced by integrating gene delivery systems: implications for the design of safer gene-based interventions in patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Progress and prospects: gene therapy for genetic diseases with helper-dependent adenoviral vectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Protective role of angiopoietin-1 in experimental pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Role of apoptosis in pulmonary hypertension: from experimental models to clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: efficacy of combined cell and eNOS gene therapy in established disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Autologous transplantation of bone marrow-derived endothelial progenitor cells attenuates monocrotaline-induced pulmonary arterial hypertension in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Cell therapy approaches for lung diseases: current status

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Mesenchymal stem cell-based prostacyclin synthase gene therapy for pulmonary hypertension rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Bone morphogenetic protein type 2 receptor gene therapy attenuates hypoxic pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Inhibition of matrix metalloproteinases by lung TIMP-1 gene transfer limits monocrotaline-induced pulmonary vascular remodeling in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

In vivo gene transfer of the O2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Intratracheal gene transfer of adrenomedullin using polyplex nanomicelles attenuates monocrotaline-induced pulmonary hypertension in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

Gene transfer of hepatocyte growth factor with prostacyclin synthase in severe pulmonary hypertension of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2011.542139

10.1517/14712598.2011.542139

21 January 2018

Identifiers

DOI

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23 August 2017

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