(Q37832722)

24 August 2017

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title

Engineering protein switches: sensors, regulators, and spare parts for biology and biotechnology (English)

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24 August 2017

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Misha V Golynskiy

1

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24 August 2017

Melissa S Koay

series ordinal

2

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24 August 2017

Jan L Vinkenborg

series ordinal

3

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24 August 2017

Maarten Merkx

series ordinal

4

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24 August 2017

26 January 2011

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24 August 2017

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24 August 2017

12

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24 August 2017

353-361

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24 August 2017

3

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Sending signals dynamically

24 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Assembly of Cell Regulatory Systems Through Protein Interaction Domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Designing customized cell signalling circuits

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Allosteric switches: remote controls for proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Structure-switching biosensors: inspired by Nature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Designing ensembles in conformational and sequence space to characterize and engineer proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

De novo computational design of retro-aldol enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Design of a Novel Globular Protein Fold with Atomic-Level Accuracy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Kemp elimination catalysts by computational enzyme design

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

ZiCo: a peptide designed to switch folded state upon binding zinc

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Computational design of affinity and specificity at protein-protein interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Practically useful: what the Rosetta protein modeling suite can do for you

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Allosteric proteins and cellular control systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Allosteric regulation and catalysis emerge via a common route.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Engineered luciferases for molecular sensing in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Engineering allosteric regulation into biological catalysts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Designing switchable enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Fluorescent-protein-based biosensors: modulation of energy transfer as a design principle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Generation of new protein functions by nonhomologous combinations and rearrangements of domains and modules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Beyond molecular beacons: optical sensors based on the binding-induced folding of proteins and polypeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Selection of allosteric beta-lactamase mutants featuring an activity regulation by transition metal ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Simultaneous intracellular chloride and pH measurements using a GFP-based sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Structural chemistry of a green fluorescent protein Zn biosensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Design of a highly specific and noninvasive biosensor suitable for real-time in vivo imaging of mercury (II) uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

In situ measurements of the pH of mammalian peroxisomes using the fluorescent protein pHluorin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Rational design of analyte channels of the green fluorescent protein for biosensor applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

A molecular sensor system based on genetically engineered alkaline phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Engineering a regulatable enzyme for homogeneous immunoassays

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Insertional protein engineering for analytical molecular sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

The design and characterization of two proteins with 88% sequence identity but different structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

A minimal sequence code for switching protein structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Circular permutation and receptor insertion within green fluorescent proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Reducing the environmental sensitivity of yellow fluorescent protein. Mechanism and applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

A genetically encoded fluorescent reporter of ATP:ADP ratio

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Differential patterning of cGMP in vascular smooth muscle cells revealed by single GFP-linked biosensors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

A bioluminescent molecular switch for glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

A yeast sensor of ligand binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Regulation of beta-lactamase activity by remote binding of heme: functional coupling of unrelated proteins through domain insertion

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Ratiometric detection of Zn(II) using chelating fluorescent protein chimeras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Directed evolution of protein switches and their application to the creation of ligand-binding proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

A molecular switch created by in vitro recombination of nonhomologous genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Creation of an allosteric enzyme by domain insertion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Linking the functions of unrelated proteins using a novel directed evolution domain insertion method

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Engineered allosteric activation of kinases in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Surface sites for engineering allosteric control in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Modular enzyme design: regulation by mutually exclusive protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Thermodynamic analysis of an antagonistic folding-unfolding equilibrium between two protein domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Allosteric switching by mutually exclusive folding of protein domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Engineering modular protein interaction switches by sequence overlap

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Light-activated DNA binding in a designed allosteric protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Rationally improving LOV domain-based photoswitches

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Design and signaling mechanism of light-regulated histidine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

A Ca2+-sensing molecular switch based on alternate frame protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

On the mechanism of protein fold-switching by a molecular sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Engineering an artificial zymogen by alternate frame protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Reprogramming control of an allosteric signaling switch through modular recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Engineering synthetic signaling proteins with ultrasensitive input/output control

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Intracellular protein interaction mapping with FRET hybrids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Reversible dimerization of Aequorea victoria fluorescent proteins increases the dynamic range of FRET-based indicators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Enhanced sensitivity of FRET-based protease sensors by redesign of the GFP dimerization interface.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Antibody detection by using a FRET-based protein conformational switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Design of protein function leaps by directed domain interface evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Structural Basis for Exquisite Specificity of Affinity Clamps, Synthetic Binding Proteins Generated through Directed Domain-interface Evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

An experimental study of GFP-based FRET, with application to intrinsically unstructured proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Evolutionary optimization of fluorescent proteins for intracellular FRET

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Rational conversion of affinity reagents into label-free sensors for Peptide motifs by designed allostery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Novel genetically encoded biosensors using firefly luciferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

An integrated-molecule-format multicolor probe for monitoring multiple activities of a bioactive small molecule.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Molecular imaging of Akt kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

An intracellular conformational sensor assay for Abl T315I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Ultrahigh-throughput screening in drop-based microfluidics for directed evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Building blocks for protein interaction devices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Strategies for protein synthetic biology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Peptide and protein building blocks for synthetic biology: from programming biomolecules to self-organized biomolecular systems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Thermodynamic basis for the optimization of binding-induced biomolecular switches and structure-switching biosensors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Variation of linker length in ratiometric fluorescent sensor proteins allows rational tuning of Zn(II) affinity in the picomolar to femtomolar range.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Dependence of Effective Molarity on Linker Length for an Intramolecular Protein−Ligand System

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Quantitative Account of the Enhanced Affinity of Two Linked scFvs Specific for Different Epitopes on the Same Antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Polymer models of protein stability, folding, and interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Biochemistry on a leash: the roles of tether length and geometry in signal integration proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Activation of specific apoptotic caspases with an engineered small-molecule-activated protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Monitoring regulated protein-protein interactions using split TEV

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Engineering a signal transduction mechanism for protein-based biosensors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Intrinsically unstructured proteins and their functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Intrinsically Disordered Proteins in Human Diseases: Introducing the D 2 Concept

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

A FRET-based method for probing the conformational behavior of an intrinsically disordered repeat domain from Bordetella pertussis adenylate cyclase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

A small molecule-regulated guanine nucleotide exchange factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Illuminating the chemistry of life: design, synthesis, and applications of "caged" and related photoresponsive compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

A genetically encoded photoactivatable Rac controls the motility of living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Estimation of the available free energy in a LOV2-J alpha photoswitch

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

A light-switchable gene promoter system

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Spatiotemporal control of cell signalling using a light-switchable protein interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Converting a protein into a switch for biosensing and functional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Finding better protein engineering strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

Modulation of Protein Dimerization by a Supramolecular Host-Guest System

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

The Affinity-Enhancing Roles of Flexible Linkers in Two-Domain DNA-Binding Proteins†

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201000642

21 January 2018

Identifiers

DOI

10.1002/CBIC.201000642

1 reference

24 August 2017

1 reference