(Q37841401)

24 August 2017

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title

Genetics of ulcerative colitis. (English)

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24 August 2017

Alexandra I Thompson

1

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24 August 2017

Charlie W Lees

series ordinal

2

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24 August 2017

publication date

12 November 2010

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Inflammatory Bowel Diseases

24 August 2017

published in

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24 August 2017

volume

17

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24 August 2017

issue

3

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24 August 2017

page(s)

831-848

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Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease

24 August 2017

cites work

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21 January 2018

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Exposed: the genetic underpinnings of ulcerative colitis relative to Crohn's disease

21 January 2018

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International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16.

21 January 2018

1 reference

Mapping of a susceptibility locus for Crohn's disease on chromosome 16

21 January 2018

1 reference

Phenotype-stratified genetic linkage study demonstrates that IBD2 is an extensive ulcerative colitis locus.

21 January 2018

1 reference

The IBD2 locus shows linkage heterogeneity between ulcerative colitis and Crohn disease

21 January 2018

1 reference

Linkage of inflammatory bowel disease to human chromosome 6p

21 January 2018

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Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease.

21 January 2018

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Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs

21 January 2018

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

21 January 2018

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

21 January 2018

1 reference

New links to the pathogenesis of Crohn disease provided by genome-wide association scans

21 January 2018

1 reference

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

21 January 2018

1 reference

Genetic markers may predict disease behavior in patients with ulcerative colitis

21 January 2018

1 reference

The molecular classification of the clinical manifestations of Crohn's disease

21 January 2018

1 reference

Clinical and genetic heterogeneity in Mexican patients with ulcerative colitis.

21 January 2018

1 reference

Analysis of genes within the HLA region affecting susceptibility to ulcerative colitis

21 January 2018

1 reference

A population- and family-based study of Canadian families reveals association of HLA DRB1*0103 with colonic involvement in inflammatory bowel disease

21 January 2018

1 reference

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

21 January 2018

1 reference

Butyrophilin-like 2 gene is associated with ulcerative colitis in the Japanese under strong linkage disequilibrium with HLA-DRB1*1502.

21 January 2018

1 reference

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

21 January 2018

1 reference

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

21 January 2018

1 reference

Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

21 January 2018

1 reference

Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype

21 January 2018

1 reference

IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease

21 January 2018

1 reference

IL23R Arg381Gln is associated with childhood onset inflammatory bowel disease in Scotland

21 January 2018

1 reference

Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4

21 January 2018

1 reference

Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci

21 January 2018

1 reference

Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult- and pediatric-onset inflammatory bowel disease in Italy

21 January 2018

1 reference

Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort

21 January 2018

1 reference

ATG16L1andIL23RAre Associated With Inflammatory Bowel Diseases but Not With Celiac Disease in The Netherlands

21 January 2018

1 reference

rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants

21 January 2018

1 reference

Association of IL23R, TNFRSF1A, and HLA-DRB1*0103 allele variants with inflammatory bowel disease phenotypes in the Finnish population.

21 January 2018

1 reference

ATG16L1 and IL23 receptor (IL23R) genes are associated with disease susceptibility in Hungarian CD patients

21 January 2018

1 reference

IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease

21 January 2018

1 reference

Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study

21 January 2018

1 reference

The immunological and genetic basis of inflammatory bowel disease

21 January 2018

1 reference

The Interleukin-23 / Interleukin-17 axis in intestinal inflammation.

21 January 2018

1 reference

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

21 January 2018

1 reference

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

21 January 2018

1 reference

T(H)-17 cells in the circle of immunity and autoimmunity

21 January 2018

1 reference

IL-17 family cytokines and the expanding diversity of effector T cell lineages

21 January 2018

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

21 January 2018

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Transforming growth factor-beta induces development of the T(H)17 lineage

21 January 2018

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TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

21 January 2018

1 reference

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

21 January 2018

1 reference

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

21 January 2018

1 reference

Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation

21 January 2018

1 reference

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

21 January 2018

1 reference

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

21 January 2018

1 reference

The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis

21 January 2018

1 reference

A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes

21 January 2018

1 reference

Investigation of association of the IL12B and IL23R genes with psoriatic arthritis

21 January 2018

1 reference

Polymorphisms of the IL12B and IL23R genes are associated with psoriasis

21 January 2018

1 reference

Interleukin-23 drives innate and T cell-mediated intestinal inflammation

21 January 2018

1 reference

IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis.

21 January 2018

1 reference

Anti-interleukin-12 antibody for active Crohn's disease

21 January 2018

1 reference

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

21 January 2018

1 reference

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)

21 January 2018

1 reference

Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis

21 January 2018

1 reference

Interleukin-17 and type 17 helper T cells

21 January 2018

1 reference

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones

21 January 2018

1 reference

Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI.

21 January 2018

1 reference

Interleukin-10-deficient mice develop chronic enterocolitis

21 January 2018

1 reference

Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation

21 January 2018

1 reference

Interleukin-10: new perspectives on an old cytokine

21 January 2018

1 reference

Inflammatory bowel disease and mutations affecting the interleukin-10 receptor

21 January 2018

1 reference

Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The Interleukin 10 Inflammatory Bowel Disease Cooperative Study Group

21 January 2018

1 reference

Safety and efficacy of recombinant human interleukin 10 in chronic active Crohn's disease. Crohn's Disease IL-10 Cooperative Study Group

21 January 2018

1 reference

Treatment of murine colitis by Lactococcus lactis secreting interleukin-10.

21 January 2018

1 reference

Ulcerative colitis--a disease characterised by the abnormal colonic epithelial cell?

21 January 2018

1 reference

Changes in colonic mucosal permeability in mouse colitis induced with dextran sulfate sodium.

21 January 2018

1 reference

Epithelial barrier defects in ulcerative colitis: characterization and quantification by electrophysiological imaging.

21 January 2018

1 reference

Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk

21 January 2018

1 reference

The molecular basis of lipoid proteinosis: mutations in extracellular matrix protein 1.

21 January 2018

1 reference

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways

21 January 2018

1 reference

Extracellular matrix protein 1 (ECM1) is over-expressed in malignant epithelial tumors

21 January 2018

1 reference

Receptor and secreted targets of Wnt-1/beta-catenin signalling in mouse mammary epithelial cells

21 January 2018

1 reference

Identification of metastasis-associated proteins in a human tumor metastasis model using the mass-mapping technique

21 January 2018

1 reference

Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship

21 January 2018

1 reference

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

21 January 2018

1 reference

Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies

21 January 2018

1 reference

Common variants at 30 loci contribute to polygenic dyslipidemia

21 January 2018

1 reference

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

21 January 2018

1 reference

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

21 January 2018

1 reference

Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes

21 January 2018

1 reference

Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos

21 January 2018

1 reference

Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst

21 January 2018

1 reference

Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon

21 January 2018

1 reference

Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease

21 January 2018

1 reference

Hepatocyte nuclear factor 4alpha, a key factor for homeostasis, cell architecture, and barrier function of the adult intestinal epithelium.

21 January 2018

1 reference

Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease

21 January 2018

1 reference

Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis.

21 January 2018

1 reference

NSAIDs suppress the expression of claudin-2 to promote invasion activity of cancer cells

21 January 2018

1 reference

Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer

21 January 2018

1 reference

Polymorphisms in E-cadherin (CDH1) result in a mis-localised cytoplasmic protein that is associated with Crohn's disease

21 January 2018

1 reference

Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin

21 January 2018

1 reference

Inflammatory bowel disease and the apical junctional complex

21 January 2018

1 reference

Protein-tyrosine phosphatase sigma is associated with ulcerative colitis

21 January 2018

1 reference

MAGI2 genetic variation and inflammatory bowel disease

21 January 2018

1 reference

Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitis

21 January 2018

1 reference

In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death

21 January 2018

1 reference

Cleavage of E-cadherin: a mechanism for disruption of the intestinal epithelial barrier by Candida albicans.

21 January 2018

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E-cadherin expression in intestinal epithelium

21 January 2018

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E-cadherin-dependent transcriptional control of apolipoprotein A-IV gene expression in intestinal epithelial cells: a role for the hepatic nuclear factor 4

21 January 2018

1 reference

Epigenetic control of the E-cadherin gene (CDH1) by CpG methylation in colectomy samples of patients with ulcerative colitis

21 January 2018

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Altered expression of laminins in Crohn's disease small intestinal mucosa

21 January 2018

1 reference

Proinflammatory cytokines TNF-alpha and IFN-gamma alter laminin expression under an apoptosis-independent mechanism in human intestinal epithelial cells

21 January 2018

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Serum laminin and collagen IV in inflammatory bowel disease

21 January 2018

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Deficiency of epithelial basement membrane laminin in ulcerative colitis affected human colonic mucosa

21 January 2018

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Expression of functionally distinct variants of the beta(4)A integrin subunit in relation to the differentiation state in human intestinal cells

21 January 2018

1 reference

Distribution of individual components of basement membrane in human colon polyps and adenocarcinomas as revealed by monoclonal antibodies

21 January 2018

1 reference

Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history.

21 January 2018

1 reference

WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells

21 January 2018

1 reference

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

21 January 2018

1 reference

Deubiquitylation and regulation of the immune response

21 January 2018

1 reference

Phospholipase A2 structure/function, mechanism, and signaling

21 January 2018

1 reference

Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).

21 January 2018

1 reference

Structure and signalling in the IL-17 receptor family

21 January 2018

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T(H)1 cells control themselves by producing interleukin-10.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/IBD.21375

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24 August 2017

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