(Q37845326)

24 August 2017

1 reference

title

Mechanisms of digit formation: Human malformation syndromes tell the story (English)

1 reference

24 August 2017

1

Sigmar Stricker

0 references

Stefan Mundlos

series ordinal

2

object named as

Stefan Mundlos

1 reference

24 August 2017

publication date

18 February 2011

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24 August 2017

published in

Developmental Dynamics

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24 August 2017

volume

240

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24 August 2017

issue

5

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24 August 2017

page(s)

990-1004

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Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning

24 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Interactions between Sox9 and beta-catenin control chondrocyte differentiation

21 January 2018

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https://api.crossref.org/works/10.1002%2FDVDY.22565

Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors

21 January 2018

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https://api.crossref.org/works/10.1002%2FDVDY.22565

Development of synovial joints

21 January 2018

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https://api.crossref.org/works/10.1002%2FDVDY.22565

Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis

21 January 2018

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https://api.crossref.org/works/10.1002%2FDVDY.22565

Sox9 is required for cartilage formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Autosomal dominant stapes ankylosis with broad thumbs and toes, hyperopia, and skeletal anomalies is caused by heterozygous nonsense and frameshift mutations in NOG, the gene encoding noggin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton

21 January 2018

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https://api.crossref.org/works/10.1002%2FDVDY.22565

Efficient chondrogenic differentiation of mesenchymal cells in micromass culture by retroviral gene transfer of BMP-2.

21 January 2018

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https://api.crossref.org/works/10.1002%2FDVDY.22565

Digit morphogenesis: is the tip different?

21 January 2018

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https://api.crossref.org/works/10.1002%2FDVDY.22565

Interdigital regulation of digit identity and homeotic transformation by modulated BMP signaling

21 January 2018

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https://api.crossref.org/works/10.1002%2FDVDY.22565

Duplications involving a conserved regulatory element downstream of BMP2 are associated with brachydactyly type A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

GDF5 is a second locus for multiple-synostosis syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

A homozygous BMPR1B mutation causes a new subtype of acromesomelic chondrodysplasia with genital anomalies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Identical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Pathogenesis of split-hand/split-foot malformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Mutation in the cartilage-derived morphogenetic protein-1 (CDMP1) gene in a kindred affected with fibular hypoplasia and complex brachydactyly (DuPan syndrome)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Wnt signaling during BMP-2 stimulation of mesenchymal chondrogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

BMP/GDF-signalling interactions during synovial joint development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Development and regeneration of the neonatal digit tip in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

BMP signaling pathways in cartilage and bone formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Reaching a genetic and molecular understanding of skeletal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

A mutation in the receptor binding site of GDF5 causes Mohr-Wriedt brachydactyly type A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Deletion and point mutations of PTHLH cause brachydactyly type E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Synovial joint formation during mouse limb skeletogenesis: roles of Indian hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Duplications of noncoding elements 5' of SOX9 are associated with brachydactyly-anonychia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

A novel R486Q mutation in BMPR1B resulting in either a brachydactyly type C/symphalangism-like phenotype or brachydactyly type A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

The apical ectodermal ridge is a timer for generating distal limb progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

A cis-regulatory site downregulates PTHLH in translocation t(8;12)(q13;p11.2) and leads to Brachydactyly Type E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Morphogenesis of digits in the avian limb is controlled by FGFs, TGFbetas, and noggin through BMP signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Expression and function of Gdf-5 during digit skeletogenesis in the embryonic chick leg bud.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Ectodermal FGFs induce perinodular inhibition of limb chondrogenesis in vitro and in vivo via FGF receptor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Activin/TGFbeta and BMP crosstalk determines digit chondrogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

The brachydactylies: a molecular disease family

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Activities of N-Myc in the developing limb link control of skeletal size with digit separation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

BMP receptor type IA in limb bud mesenchyme regulates distal outgrowth and patterning.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Sox9, a key transcription factor of bone morphogenetic protein-2-induced chondrogenesis, is activated through BMP pathway and a CCAAT box in the proximal promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Bone morphogenetic protein-2 induces chromatin remodeling and modification at the proximal promoter of Sox9 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

The transcription factor SOX9 regulates cell cycle and differentiation genes in chondrocytic CFK2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Interaction of Ihh and BMP/Noggin signaling during cartilage differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

A cellular lineage analysis of the chick limb bud.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Brachydactyly type A2 associated with a defect in proGDF5 processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Mutations in CDMP1 cause autosomal dominant brachydactyly type C

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Bone morphogenetic protein signaling in limb outgrowth and patterning

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

BMP receptor signaling is required for postnatal maintenance of articular cartilage

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Inhibition of chondrogenesis by Wnt gene expression in vivo and in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Modulation of GDF5/BRI-b signalling through interaction with the tyrosine kinase receptor Ror2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Fgf signaling controls the number of phalanges and tip formation in developing digits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Distinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Brachydactyly type C caused by a homozygous missense mutation in the prodomain of CDMP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

A gradient of ROR2 protein stability and membrane localization confers brachydactyly type B or Robinow syndrome phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Indian hedgehog gene is a target of the bone morphogenetic protein signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

The transcription factors L-Sox5 and Sox6 are essential for cartilage formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

A description of chick wing bud development and a model of limb morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

GDF5 coordinates bone and joint formation during digit development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Functions of FGF signalling from the apical ectodermal ridge in limb development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Unique SMAD1/5/8 activity at the phalanx-forming region determines digit identity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Developmental failure of phalanges in the absence of growth/differentiation factor 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Mutations of the NOG gene in individuals with proximal symphalangism and multiple synostosis syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

A human chondrodysplasia due to a mutation in a TGF-beta superfamily member

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Patterning Systems—From One End of the Limb to the Other

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Making digit patterns in the vertebrate limb

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Integration of growth and specification in chick wing digit-patterning.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Role of CDMP-1 in skeletal morphogenesis: promotion of mesenchymal cell recruitment and chondrocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

MYCN haploinsufficiency is associated with reduced brain size and intestinal atresias in Feingold syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Wnt-ligand-dependent interaction of TAK1 (TGF-beta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Growth and patterning in the limb: signaling gradients make the decision

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

The transcription factor Sox9 is involved in BMP-2 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

The bone morphogenetic protein antagonist Noggin is regulated by Sox9 during endochondral differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Vertebrate limb bud development: moving towards integrative analysis of organogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Uncoupling Sonic Hedgehog Control of Pattern and Expansion of the Developing Limb Bud

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

A new role for BMP5 during limb development acting through the synergic activation of Smad and MAPK pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Yin and Yang in BMP signaling: Impact on the pathology of diseases and potential for tissue regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

Bone Morphogenetic Protein-2 (BMP-2) Inhibits Muscle Development and Promotes Cartilage Formation in Chick Limb Bud Cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

7 January 2021

The effect of overexpression of BMPs and GDF-5 on the development of chick limb skeletal elements

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

7 January 2021

Multiple roles of mesenchymal -catenin during murine limb patterning

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

7 January 2021

Changes in rate of cellular proliferation during the differentiation of cartilage and muscle in the mesenchyme of the embryonic chick wing

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

7 January 2021

Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

7 January 2021

BMPs are required at two steps of limb chondrogenesis: formation of prechondrogenic condensations and their differentiation into chondrocytes

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

7 January 2021

Spatial and temporal patterns of cell death in limb bud mesoderm after apical ectodermal ridge removal

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

7 January 2021

The establishment of the cartilage pattern in the embryonic chick wing, and evidence for a role of the dorsal and ventral ectoderm in normal wing development

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

7 January 2021

Cell Density and Cell Division in the Early Morphogenesis of the Chick Wing

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

7 January 2021

A novel mutation in GDF5 causes autosomal dominant symphalangism in two Chinese families

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

7 January 2021

Novel point mutations in GDF5 associated with two distinct limb malformations in Chinese: brachydactyly type C and proximal symphalangism

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22565

7 January 2021

Identifiers

DOI

10.1002/DVDY.22565

1 reference

24 August 2017

1 reference