(Q37855730)

English

Nucleolar aggresomes as counterparts of cytoplasmic aggresomes in proteotoxic stress. Proteasome inhibitors induce nuclear ribonucleoprotein inclusions that accumulate several key factors of neurodegenerative diseases and cancer

scientific article published on 21 March 2011

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scholarly article

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Europe PubMed Central

24 August 2017

1 reference

Europe PubMed Central

Nucleolar aggresomes as counterparts of cytoplasmic aggresomes in proteotoxic stress. Proteasome inhibitors induce nuclear ribonucleoprotein inclusions that accumulate several key factors of neurodegenerative diseases and cancer (English)

1 reference

Europe PubMed Central

24 August 2017

ribonucleoprotein complex

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based on heuristic

inferred from title

neurodegeneration

1 reference

based on heuristic

inferred from title

author name string

Leena Latonen

1

1 reference

Europe PubMed Central

24 August 2017

language of work or name

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publication date

21 March 2011

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Europe PubMed Central

24 August 2017

1 reference

Europe PubMed Central

24 August 2017

33

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Europe PubMed Central

24 August 2017

5

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Europe PubMed Central

24 August 2017

386-395

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Europe PubMed Central

24 August 2017

Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy

1 reference

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The 26 S proteasome: from basic mechanisms to drug targeting

1 reference

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21 January 2018

Operational definition of intrinsically unstructured protein sequences based on susceptibility to the 20S proteasome.

1 reference

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21 January 2018

Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Nonproteolytic functions of ubiquitin in cell signaling

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Polyubiquitin binding and disassembly by deubiquitinating enzymes

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Intracellular localization of proteasomes

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Protein degradation and protection against misfolded or damaged proteins

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

The ubiquitin proteasome system in neuropathology

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Aggresomes: a cellular response to misfolded proteins

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Formation of nuclear HSF1 granules varies depending on stress stimuli

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Proteasome inhibitors: from research tools to drug candidates

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Nucleolus: from structure to dynamics

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

The multifunctional nucleolus

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Nucleolus: the fascinating nuclear body

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Nucleolar proteome dynamics

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

The nucleolus under stress

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Proteins associated with the promyelocytic leukemia gene product (PML)-containing nuclear body move to the nucleolus upon inhibition of proteasome-dependent protein degradation

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

p53 and MDM2 are regulated by PI-3-kinases on multiple levels under stress induced by UV radiation and proteasome dysfunction

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

p53 localizes to intranucleolar regions distinct from the ribosome production compartments.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Accumulation of c-Myc and proteasomes at the nucleoli of cells containing elevated c-Myc protein levels

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Localization of proteasomes and proteasomal proteolysis in the mammalian interphase cell nucleus by systematic application of immunocytochemistry

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

p53 is localized to a sub-nucleolar compartment after proteasomal inhibition in an energy-dependent manner

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Analysis of nucleolar protein dynamics reveals the nuclear degradation of ribosomal proteins

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Molecular mechanisms of eukaryotic pre-mRNA 3' end processing regulation

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

CRM1-mediated nuclear export: to the pore and beyond.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Efficient NES-dependent protein nuclear export requires ongoing synthesis and export of mRNAs.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Nuclear mRNA accumulation causes nucleolar fragmentation in yeast mtr2 mutant

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

General, rapid, and transcription-dependent fragmentation of nucleolar antigens in S. cerevisiae mRNA export mutants

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

The many pathways of RNA degradation

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Polyadenylation of ribosomal RNA in human cells

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Adenylation and exosome-mediated degradation of cotranscriptionally cleaved pre-messenger RNA in human cells

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

A role for ubiquitin in the clearance of nonfunctional rRNAs

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Surveillance of nuclear-restricted pre-ribosomes within a subnucleolar region of Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Depletion of the yeast nuclear exosome subunit Rrp6 results in accumulation of polyadenylated RNAs in a discrete domain within the nucleolus

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Potential roles for ubiquitin and the proteasome during ribosome biogenesis

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

A proteomics approach to understanding protein ubiquitination

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

The ARF/p53 pathway

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

The multiple levels of regulation by p53 ubiquitination

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Nucleolar disruption ensures nuclear accumulation of p21 upon DNA damage.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Nucleocytoplasmic traffic of CPEB1 and accumulation in Crm1 nucleolar bodies

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Nucleolar trafficking is essential for nuclear export of intronless herpesvirus mRNA.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Nucleolar disruption impairs Kaposi's sarcoma-associated herpesvirus ORF57-mediated nuclear export of intronless viral mRNAs

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Alphavirus M1 induces apoptosis of malignant glioma cells via downregulation and nucleolar translocation of p21WAF1/CIP1 protein

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

SUMO on the road to neurodegeneration

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Molecular mechanisms and potential therapeutical targets in Huntington's disease

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

The malin-laforin complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Recent advances in the molecular basis of Lafora's progressive myoclonus epilepsy.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Huntington's disease--like 2 is associated with CUG repeat-containing RNA foci.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Myotonic dystrophies 1 and 2: complex diseases with complex mechanisms.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

The spinocerebellar ataxia type 1 protein, ataxin-1, has RNA-binding activity that is inversely affected by the length of its polyglutamine tract

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

RNA association and nucleocytoplasmic shuttling by ataxin-1

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Nuclear localization of the spinocerebellar ataxia type 7 protein, ataxin-7

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Spinocerebellar ataxia type 8 larger triplet expansion alters histone modification and induces RNA foci

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Spinocerebellar ataxia type 31 is associated with "inserted" penta-nucleotide repeats containing (TGGAA)n

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Inactivation of hnRNP K by expanded intronic AUUCU repeat induces apoptosis via translocation of PKCdelta to mitochondria in spinocerebellar ataxia 10

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

RNA toxicity is a component of ataxin-3 degeneration in Drosophila

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

FRG1P-mediated aggregation of proteins involved in pre-mRNA processing

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Nuclear inclusions in oculopharyngeal muscular dystrophy consist of poly(A) binding protein 2 aggregates which sequester poly(A) RNA

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Oculopharyngeal muscular dystrophy-like nuclear inclusions are present in normal magnocellular neurosecretory neurons of the hypothalamus

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Lafora disease proteins malin and laforin are recruited to aggresomes in response to proteasomal impairment

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Proteasome inhibitor induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

The ubiquitin ligase E6-AP is induced and recruited to aggresomes in response to proteasome inhibition and may be involved in the ubiquitination of Hsp70-bound misfolded proteins

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Mild heat and proteotoxic stress promote unique subcellular trafficking and nucleolar accumulation of RGS6 and other RGS proteins. Role of the RGS domain in stress-induced trafficking of RGS proteins.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Intracellular trafficking of heat shock factor 2

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

c-Myc localization within the nucleus: evidence for association with the PML nuclear body

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Nucleolar targeting of RelA(p65) is regulated by COMMD1-dependent ubiquitination

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Subcellular distribution of human RDM1 protein isoforms and their nucleolar accumulation in response to heat shock and proteotoxic stress

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Proteomic characterization of an isolated fraction of synthetic proteasome inhibitor (PSI)-induced inclusions in PC12 cells might offer clues to aggresomes as a cellular defensive response against proteasome inhibition by PSI.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Proteomic characterization of aggregating proteins after the inhibition of the ubiquitin proteasome system

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

The heavy metal cadmium induces valosin-containing protein (VCP)-mediated aggresome formation.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201100008

21 January 2018

Identifiers

10.1002/BIES.201100008

1 reference

Europe PubMed Central

24 August 2017

1 reference

Europe PubMed Central

24 August 2017

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