(Q37855886)

24 August 2017

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title

New approaches to targeting the actin cytoskeleton for chemotherapy (English)

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24 August 2017

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Teresa T Bonello

1

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24 August 2017

Justine R Stehn

series ordinal

2

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24 August 2017

Peter W Gunning

series ordinal

3

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24 August 2017

publication date

1 October 2009

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Future Medicinal Chemistry

24 August 2017

published in

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24 August 2017

volume

1

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24 August 2017

issue

7

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24 August 2017

page(s)

1311-1331

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Is anticancer drug development heading in the right direction?

24 August 2017

cites work

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Targeting microtubules for cancer chemotherapy

21 January 2018

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Functional specificity of actin isoforms

21 January 2018

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21 January 2018

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Interference with actin dynamics is superior to disturbance of microtubule function in the inhibition of human ovarian cancer cell motility

21 January 2018

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Tropomyosin-based regulation of the actin cytoskeleton in time and space

21 January 2018

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21 January 2018

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Structure, assembly, and dynamics of actin filaments in situ and in vitro

21 January 2018

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Thin filament-mediated regulation of cardiac contraction

21 January 2018

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High level expression of transfected beta- and gamma-actin genes differentially impacts on myoblast cytoarchitecture

21 January 2018

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Cellular motility driven by assembly and disassembly of actin filaments

21 January 2018

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Microtubules and actin filaments: dynamic targets for cancer chemotherapy

21 January 2018

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Small-molecule inhibitors of actin dynamics and cell motility.

21 January 2018

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Cytoskeletal agents inhibit motility and adherence of human tumor cells

21 January 2018

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In vitro screening of crude extracts and pure metabolites obtained from marine invertebrates for the treatment of breast cancer.

21 January 2018

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Jasplakinolide's inhibition of the growth of prostate carcinoma cells in vitro with disruption of the actin cytoskeleton.

21 January 2018

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Characterization of the activities of actin-affecting drugs on tumor cell migration

21 January 2018

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Endothelial cell migration during angiogenesis

21 January 2018

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Regulation of the actin cytoskeleton in cancer cell migration and invasion

21 January 2018

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Regulation of actin assembly associated with protrusion and adhesion in cell migration

21 January 2018

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Two distinct actin networks drive the protrusion of migrating cells

21 January 2018

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The lamellipodium: where motility begins

21 January 2018

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The many faces of actin: matching assembly factors with cellular structures

21 January 2018

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Filopodia: molecular architecture and cellular functions

21 January 2018

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The matrix corroded: podosomes and invadopodia in extracellular matrix degradation

21 January 2018

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Foot and mouth: podosomes, invadopodia and circular dorsal ruffles

21 January 2018

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Intravital imaging of cell movement in tumours

21 January 2018

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Stress fibers are generated by two distinct actin assembly mechanisms in motile cells

21 January 2018

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The comings and goings of actin: coupling protrusion and retraction in cell motility

21 January 2018

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Mechanisms of actin stress fibre assembly.

21 January 2018

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21 January 2018

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Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton

21 January 2018

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Rho GTPases: potential candidates for anticancer therapy

21 January 2018

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Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion

21 January 2018

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The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requirements for actin dynamics

21 January 2018

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The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration

21 January 2018

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Cofilin produces newly polymerized actin filaments that are preferred for dendritic nucleation by the Arp2/3 complex

21 January 2018

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Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin.

21 January 2018

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Proteins of the ADF/cofilin family: essential regulators of actin dynamics

21 January 2018

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Cofilin promotes actin polymerization and defines the direction of cell motility

21 January 2018

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Ins and outs of ADF/cofilin activity and regulation

21 January 2018

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A common cofilin activity cycle in invasive tumor cells and inflammatory cells

21 January 2018

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Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation

21 January 2018

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Spatial and temporal control of cofilin activity is required for directional sensing during chemotaxis

21 January 2018

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Differential protein expression profiling by iTRAQ-2DLC-MS/MS of lung cancer cells undergoing epithelial-mesenchymal transition reveals a migratory/invasive phenotype

21 January 2018

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Identification of differentially expressed, tumor-associated proteins in oral squamous cell carcinoma by proteomic analysis

21 January 2018

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Proteome analysis of hepatocellular carcinoma cell strains, MHCC97-H and MHCC97-L, with different metastasis potentials

21 January 2018

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LIM kinase 1 is essential for the invasive growth of prostate epithelial cells: implications in prostate cancer

21 January 2018

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A role for LIM kinase in cancer invasion.

21 January 2018

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Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors.

21 January 2018

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Phosphorylation of ADF/cofilin abolishes EGF-induced actin nucleation at the leading edge and subsequent lamellipod extension

21 January 2018

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Cofilin activity during insulin-like growth factor I-stimulated neuroblastoma cell motility.

21 January 2018

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The cofilin pathway in breast cancer invasion and metastasis

21 January 2018

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Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors.

21 January 2018

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Expression of cofilin isoforms during development of mouse striated muscles.

21 January 2018

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Gelsolin superfamily proteins: key regulators of cellular functions.

21 January 2018

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Severing of F-actin by the amino-terminal half of gelsolin suggests internal cooperativity in gelsolin

21 January 2018

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Gelsolin as a calcium-regulated actin filament-capping protein

21 January 2018

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Gelsolin is a downstream effector of rac for fibroblast motility

21 January 2018

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Gelsolin-induced epithelial cell invasion is dependent on Ras-Rac signaling

21 January 2018

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Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin

21 January 2018

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Delayed retraction of filopodia in gelsolin null mice

21 January 2018

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Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength

21 January 2018

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Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis

21 January 2018

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Inhibition of apoptosis by the actin-regulatory protein gelsolin

21 January 2018

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Pancreatic cancer cells overexpress gelsolin family-capping proteins, which contribute to their cell motility

21 January 2018

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Murine androgen-independent neuroendocrine carcinoma promotes metastasis of human prostate cancer cell line LNCaP.

21 January 2018

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Downregulation of gelsolin family proteins counteracts cancer cell invasion in vitro

21 January 2018

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Prognostic significance of gelsolin expression level and variability in non-small cell lung cancer.

21 January 2018

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Tissue microarray analysis of cytoskeletal actin-associated biomarkers gelsolin and E-cadherin in urothelial carcinoma

21 January 2018

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The Arp2/3 complex nucleates actin filament branches from the sides of pre-existing filaments

21 January 2018

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Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins.

21 January 2018

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The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments

21 January 2018

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Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex

21 January 2018

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Regulation of actin dynamics by WASP and WAVE family proteins.

21 January 2018

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Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex

21 January 2018

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Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate

21 January 2018

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Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia

21 January 2018

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Filopodia formation in the absence of functional WAVE- and Arp2/3-complexes

21 January 2018

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WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells

21 January 2018

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Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

21 January 2018

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Mechanism of filopodia initiation by reorganization of a dendritic network

21 January 2018

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Arp2/3 complex is important for filopodia formation, growth cone motility, and neuritogenesis in neuronal cells

21 January 2018

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N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility

21 January 2018

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The Rho family GTPase Rif induces filopodia through mDia2.

21 January 2018

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Mechanism and function of formins in the control of actin assembly

21 January 2018

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Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells

21 January 2018

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Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages

21 January 2018

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Podosome formation in cultured A7r5 vascular smooth muscle cells requires Arp2/3-dependent de-novo actin polymerization at discrete microdomains.

21 January 2018

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Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin

21 January 2018

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Imaging sites of N-wasp activity in lamellipodia and invadopodia of carcinoma cells

21 January 2018

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Characterization of the 7q21-q22 amplicon identifies ARPC1A, a subunit of the Arp2/3 complex, as a regulator of cell migration and invasion in pancreatic cancer

21 January 2018

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Correlation between liver metastasis of the colocalization of actin-related protein 2 and 3 complex and WAVE2 in colorectal carcinoma

21 January 2018

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Increased expression of Wiskott-Aldrich syndrome protein family verprolin-homologous protein 2 correlated with poor prognosis of hepatocellular carcinoma.

21 January 2018

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Expression of the WASP verprolin-homologues (WAVE members) in human breast cancer

21 January 2018

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Characterization of two classes of small molecule inhibitors of Arp2/3 complex

21 January 2018

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Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation

21 January 2018

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Genome-wide screening of genes showing altered expression in liver metastases of human colorectal cancers by cDNA microarray

21 January 2018

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N-WASP is a putative tumour suppressor in breast cancer cells, in vitro and in vivo, and is associated with clinical outcome in patients with breast cancer

21 January 2018

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Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation

21 January 2018

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Activation of Arp2/3 complex-mediated actin polymerization by cortactin

21 January 2018

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Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP

21 January 2018

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Cortactin branches out: roles in regulating protrusive actin dynamics

21 January 2018

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Cortactin in tumor invasiveness

21 January 2018

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Cortactin promotes cell motility by enhancing lamellipodial persistence

21 January 2018

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Overexpression of EMS1/cortactin in NIH3T3 fibroblasts causes increased cell motility and invasion in vitro

21 January 2018

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Dissecting the functional domain requirements of cortactin in invadopodia formation

21 January 2018

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Cortactin has an essential and specific role in osteoclast actin assembly

21 January 2018

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Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function

21 January 2018

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Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport

21 January 2018

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Aggressiveness of HNSCC tumors depends on expression levels of cortactin, a gene in the 11q13 amplicon

21 January 2018

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Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia

21 January 2018

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Recent advances in MMP inhibitor design

21 January 2018

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Transgenic mice with mammary gland targeted expression of human cortactin do not develop (pre-malignant) breast tumors: studies in MMTV-cortactin and MMTV-cortactin/-cyclin D1 bitransgenic mice

21 January 2018

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Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma.

21 January 2018

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Amplification and overexpression of CTTN (EMS1) contribute to the metastasis of esophageal squamous cell carcinoma by promoting cell migration and anoikis resistance.

21 January 2018

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Nonmuscle myosin II moves in new directions

21 January 2018

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Replacement of nonmuscle myosin II-B with II-A rescues brain but not cardiac defects in mice.

21 January 2018

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Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in mice

21 January 2018

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Nonmuscle myosin II-B is required for normal development of the mouse heart

21 January 2018

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Myosin II and mechanotransduction: a balancing act.

21 January 2018

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Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migration

21 January 2018

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Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration

21 January 2018

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Non-muscle myosin IIA differentially regulates intestinal epithelial cell restitution and matrix invasion

21 January 2018

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Segregation and activation of myosin IIB creates a rear in migrating cells

21 January 2018

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Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts.

21 January 2018

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The role of myosin II in glioma invasion of the brain

21 January 2018

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Inhibition of pancreatic adenocarcinoma cellular invasiveness by blebbistatin: a novel myosin II inhibitor

21 January 2018

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Role of myosin II activity and the regulation of myosin light chain phosphorylation in astrocytomas

21 January 2018

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Blebbistatin specifically inhibits actin-myosin interaction in mouse cardiac muscle

21 January 2018

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Gene dosage affects the cardiac and brain phenotype in nonmuscle myosin II-B-depleted mice

21 January 2018

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Dependence of metastatic cancer cell invasion on MLCK-catalyzed phosphorylation of myosin regulatory light chain

21 January 2018

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Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2.

21 January 2018

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Myosin light chain kinase plays a role in the regulation of epithelial cell survival

21 January 2018

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Inhibiting myosin light chain kinase retards the growth of mammary and prostate cancer cells.

21 January 2018

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Tropomyosin isoforms: divining rods for actin cytoskeleton function

21 January 2018

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Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments.

21 January 2018

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Tropomyosin regulates elongation by formin at the fast-growing end of the actin filament.

21 January 2018

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Specification of actin filament function and molecular composition by tropomyosin isoforms

21 January 2018

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Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin

21 January 2018

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Tropomyosin localization reveals distinct populations of microfilaments in neurites and growth cones.

21 January 2018

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The rat alpha-tropomyosin gene generates a minimum of six different mRNAs coding for striated, smooth, and nonmuscle isoforms by alternative splicing

21 January 2018

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Specialisation of the tropomyosin composition of actin filaments provides new potential targets for chemotherapy.

21 January 2018

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Tropomyosin is decreased in transformed cells

21 January 2018

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Tropomyosin isoforms in chicken embryo fibroblasts: purification, characterization, and changes in Rous sarcoma virus-transformed cells

21 January 2018

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Tropomyosins as interpreters of the signalling environment to regulate the local cytoskeleton

21 January 2018

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Regulation of microfilament organization and anchorage-independent growth by tropomyosin 1.

21 January 2018

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Suppression of the transformed phenotype of breast cancer by tropomyosin-1.

21 January 2018

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Tropomyosins are present in lamellipodia of motile cells

21 January 2018

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Forced expression of tropomyosin 2 or 3 in v-Ki-ras-transformed fibroblasts results in distinct phenotypic effects

21 January 2018

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Role of high-molecular weight tropomyosins in TGF-beta-mediated control of cell motility

21 January 2018

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Decreased expression of a single tropomyosin isoform, TM5/TM30nm, results in reduction in motility of highly metastatic B16-F10 mouse melanoma cells

21 January 2018

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Tropomyosin 4 regulates adhesion structures and resorptive capacity in osteoclasts

21 January 2018

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Actin-targeting natural products: structures, properties and mechanisms of action

21 January 2018

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Microfilament actin remodeling as a potential target for cancer drug development

21 January 2018

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p21-activated kinases in cancer

21 January 2018

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Dominant negative effect of cytoplasmic actin isoproteins on cardiomyocyte cytoarchitecture and function

21 January 2018

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'Clean' or 'Dirty' – Just How Selective Do Drugs Need To Be?

21 January 2018

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Initiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cells

21 January 2018

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The F-actin side binding activity of the Arp2/3 complex is essential for actin nucleation and lamellipod extension

21 January 2018

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Domain Movement in Gelsolin: A Calcium-Activated Switch

21 January 2018

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Myosin IIA regulates cell motility and actomyosin–microtubule crosstalk

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/FMC.09.99

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24 August 2017

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