(Q37855930)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21426205%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

review article

1 reference

title

Recent advances in the biology and medicinal chemistry of TRPA1 (English)

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26 January 2020

3

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26 January 2020

author name string

Jason C Rech

1

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26 January 2020

William A Eckert

2

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26 January 2020

Tue Banke

4

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26 January 2020

Anindya Bhattacharya

5

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26 January 2020

Alan D Wickenden

6

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26 January 2020

publication date

1 May 2010

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Future Medicinal Chemistry

26 January 2020

published in

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26 January 2020

volume

2

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26 January 2020

issue

5

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26 January 2020

page(s)

843-858

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An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts

26 January 2020

cites work

1 reference

TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons

21 January 2018

1 reference

TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells

21 January 2018

1 reference

Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing

21 January 2018

1 reference

ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

21 January 2018

1 reference

Pungent products from garlic activate the sensory ion channel TRPA1

21 January 2018

1 reference

Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs

21 January 2018

1 reference

Transient receptor potential channel A1 involved in sensory transduction of rat urinary bladder through C-fiber pathway

21 January 2018

1 reference

Functional TRP and ASIC-like channels in cultured urothelial cells from the rat.

21 January 2018

1 reference

Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder

21 January 2018

1 reference

Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin

21 January 2018

1 reference

Increased TRPA1, TRPM8, and TRPV2 expression in dorsal root ganglia by nerve injury

21 January 2018

1 reference

TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury

21 January 2018

1 reference

Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin

21 January 2018

1 reference

TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents

21 January 2018

1 reference

TRPA1 mediates the noxious effects of natural sesquiterpene deterrents

21 January 2018

1 reference

Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

21 January 2018

1 reference

The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin.

21 January 2018

1 reference

TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol

21 January 2018

1 reference

TRPA1 mediates formalin-induced pain

21 January 2018

1 reference

Transient receptor potential A1 mediates acetaldehyde-evoked pain sensation

21 January 2018

1 reference

Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases

21 January 2018

1 reference

TRPA1 is a major oxidant sensor in murine airway sensory neurons

21 January 2018

1 reference

Tear gasses CN, CR, and CS are potent activators of the human TRPA1 receptor

21 January 2018

1 reference

TRPA1 is differentially modulated by the amphipathic molecules trinitrophenol and chlorpromazine.

21 January 2018

1 reference

21 January 2018

1 reference

Activation of TRPA1 by farnesyl thiosalicylic acid

21 January 2018

1 reference

Zinc activates damage-sensing TRPA1 ion channels

21 January 2018

1 reference

Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels

21 January 2018

1 reference

Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress

21 January 2018

1 reference

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

21 January 2018

1 reference

Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1.

21 January 2018

1 reference

Prostaglandin-induced activation of nociceptive neurons via direct interaction with transient receptor potential A1 (TRPA1).

21 January 2018

1 reference

TRPV1 and TRPA1 mediate peripheral nitric oxide-induced nociception in mice

21 January 2018

1 reference

Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1.

21 January 2018

1 reference

TRP channel activation by reversible covalent modification

21 January 2018

1 reference

Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines

21 January 2018

1 reference

Activation of TRPA1 channels by the fatty acid amide hydrolase inhibitor 3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597).

21 January 2018

1 reference

Bimodal action of menthol on the transient receptor potential channel TRPA1.

21 January 2018

1 reference

Transient receptor potential channels in sensory neurons are targets of the antimycotic agent clotrimazole

21 January 2018

1 reference

Methyl p-hydroxybenzoate causes pain sensation through activation of TRPA1 channels

21 January 2018

1 reference

Cannabinoid WIN 55,212-2 regulates TRPV1 phosphorylation in sensory neurons

21 January 2018

1 reference

Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs

21 January 2018

1 reference

General anesthetics activate a nociceptive ion channel to enhance pain and inflammation

21 January 2018

1 reference

Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels

21 January 2018

1 reference

Transient receptor potential channel A1 is directly gated by calcium ions

21 January 2018

1 reference

Direct activation of the ion channel TRPA1 by Ca2+.

21 January 2018

1 reference

Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization.

21 January 2018

1 reference

The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions.

21 January 2018

1 reference

Inhibition of transient receptor potential A1 channel by phosphatidylinositol-4,5-bisphosphate

21 January 2018

1 reference

Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators

21 January 2018

1 reference

Phospholipase C mediated modulation of TRPV1 channels.

21 January 2018

1 reference

Intracellular alkalization causes pain sensation through activation of TRPA1 in mice

21 January 2018

1 reference

Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain

21 January 2018

1 reference

Nociceptive signals induce trafficking of TRPA1 to the plasma membrane

21 January 2018

1 reference

Cold sensitivity of recombinant TRPA1 channels

21 January 2018

1 reference

TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction

21 January 2018

1 reference

TRPA1 acts as a cold sensor in vitro and in vivo

21 January 2018

1 reference

TRPA1 and cold transduction: an unresolved issue?

21 January 2018

1 reference

Burning cold: involvement of TRPA1 in noxious cold sensation

21 January 2018

1 reference

Caenorhabditis elegans TRPA-1 functions in mechanosensation

21 January 2018

1 reference

Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function

21 January 2018

1 reference

painless, a Drosophila Gene Essential for Nociception

21 January 2018

1 reference

TRPA1 modulates mechanotransduction in cutaneous sensory neurons.

21 January 2018

1 reference

Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors

21 January 2018

1 reference

Transient receptor potential A1 mediates an osmotically activated ion channel

21 January 2018

1 reference

The mechanosensitive cell line ND-C does not express functional thermoTRP channels

21 January 2018

1 reference

Pronociceptive response elicited by TRPA1 receptor activation in mice

21 January 2018

1 reference

HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity

21 January 2018

1 reference

A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition.

21 January 2018

1 reference

Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1.

21 January 2018

1 reference

The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation.

21 January 2018

1 reference

Transient receptor potential ankyrin-1 participates in visceral hyperalgesia following experimental colitis

21 January 2018

1 reference

Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats.

21 January 2018

1 reference

The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli

21 January 2018

1 reference

Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals

21 January 2018

1 reference

Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: increased expression of ATF-3 and pharmacological characterisation.

21 January 2018

1 reference

Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents.

21 January 2018

1 reference

Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control

21 January 2018

1 reference

TRPA1: a potential target for anti-tussive therapy

21 January 2018

1 reference

Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal

21 January 2018

1 reference

TRPA1 channels mediate cold temperature sensing in mammalian vagal sensory neurons: pharmacological and genetic evidence.

21 January 2018

1 reference

A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma

21 January 2018

1 reference

Nicotine activates the chemosensory cation channel TRPA1.

21 January 2018

1 reference

Desflurane induces airway contraction mainly by activating transient receptor potential A1 of sensory C-fibers

21 January 2018

1 reference

Transient receptor potential ankyrin 1 mediates toluene diisocyanate-evoked respiratory irritation

21 January 2018

1 reference

TRPA1 agonists evoke coughing in guinea pig and human volunteers

21 January 2018

1 reference

Contractile mechanisms coupled to TRPA1 receptor activation in rat urinary bladder.

21 January 2018

1 reference

Transient receptor potential A1 (TRPA1) activity in the human urethra--evidence for a functional role for TRPA1 in the outflow region

21 January 2018

1 reference

TRPA1 and TRPV1 activation is a novel adjuvant effect mechanism in contact hypersensitivity

21 January 2018

1 reference

TRPA1 modulators in preclinical development

21 January 2018

1 reference

Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels

21 January 2018

1 reference

TRPA1 channels: novel targets of 1,4-dihydropyridines

21 January 2018

1 reference

Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists

21 January 2018

1 reference

Molecular determinants of species-specific activation or blockade of TRPA1 channels

21 January 2018

1 reference

TRPA1: the species difference

21 January 2018

1 reference