(Q37856257)

24 August 2017

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title

Increasing recognition of the importance of aldehyde oxidase in drug development and discovery (English)

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24 August 2017

Enrico Garattini

1

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24 August 2017

Mineko Terao

series ordinal

2

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24 August 2017

language of work or name

English

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publication date

23 March 2011

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24 August 2017

published in

Drug Metabolism Reviews

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24 August 2017

volume

43

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24 August 2017

issue

3

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24 August 2017

page(s)

374-386

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Purification and mechanism of human aldehyde oxidase expressed in Escherichia coli

24 August 2017

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Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity

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A genomic analysis of adult T-cell leukemia

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21 January 2018

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Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: structure-based mechanism of conversion

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Mutational analysis of the xanthine dehydrogenase gene in a Turkish family with autosomal recessive classical xanthinuria

21 January 2018

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The dual substrate specificity of aldehyde oxidase 1 for retinal and acetaldehyde and its role in ABCA1 mediated efflux

21 January 2018

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Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma

21 January 2018

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In silico and in vitro pharmacogenetic analysis in mice

21 January 2018

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Gene expression profiling reveals stromal genes expressed in common between Barrett's esophagus and adenocarcinoma

21 January 2018

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Fibroblast growth factor 9 has oncogenic activity and is a downstream target of Wnt signaling in ovarian endometrioid adenocarcinomas

21 January 2018

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Tandem orientation of duplicated xanthine dehydrogenase genes from Arabidopsis thaliana: differential gene expression and enzyme activities

21 January 2018

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Oxidation of Selected Pteridine Derivatives by Mammalian Liver Xanthine Oxidase and Aldehyde Oxidase

21 January 2018

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Cloning, expression, and characterization of male cynomolgus monkey liver aldehyde oxidase.

21 January 2018

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A compendium of gene expression in normal human tissues

21 January 2018

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Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray

21 January 2018

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Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli

21 January 2018

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Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays

21 January 2018

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Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide

21 January 2018

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Experimental trial for diagnosis of pancreatic ductal carcinoma based on gene expression profiles of pancreatic ductal cells.

21 January 2018

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Human liver aldehyde oxidase: differential inhibition of oxidation of charged and uncharged substrates

21 January 2018

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Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer

21 January 2018

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Mesenchymal stem cells within tumour stroma promote breast cancer metastasis

21 January 2018

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Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis.

21 January 2018

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Whole genome analysis for liver metastasis gene signatures in colorectal cancer.

21 January 2018

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Aldehyde oxidase-catalyzed metabolism of N1-methylnicotinamide in vivo and in vitro in chimeric mice with humanized liver

21 January 2018

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Characterization of superoxide production from aldehyde oxidase: an important source of oxidants in biological tissues

21 January 2018

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The aldehyde oxidase gene cluster in mice and rats. Aldehyde oxidase homologue 3, a novel member of the molybdo-flavoenzyme family with selective expression in the olfactory mucosa.

21 January 2018

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Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival

21 January 2018

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Gene expression profiling identifies clinically relevant subtypes of prostate cancer

21 January 2018

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Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines

21 January 2018

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Previously unidentified changes in renal cell carcinoma gene expression identified by parametric analysis of microarray data

21 January 2018

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Nitric oxide production from nitrite occurs primarily in tissues not in the blood: critical role of xanthine oxidase and aldehyde oxidase

21 January 2018

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Characterization of the magnitude and mechanism of aldehyde oxidase-mediated nitric oxide production from nitrite

21 January 2018

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Sex-determining region Y box 4 is a transforming oncogene in human prostate cancer cells

21 January 2018

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Gene expression analysis of prostate cancers

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Cell biology of molybdenum

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is downregulated by adiponectin and fenofibric acid in hepatocytes in vitro.

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Tissue-specific mRNA expression profiles of human phase I metabolizing enzymes except for cytochrome P450 and phase II metabolizing enzymes

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560606

The conversion of xanthine dehydrogenase to xanthine oxidase and the role of the enzyme in reperfusion injury

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Purification and characterization of multiple forms of rat liver xanthine oxidoreductase expressed in baculovirus-insect cell system

21 January 2018

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Mammalian xanthine oxidoreductase - mechanism of transition from xanthine dehydrogenase to xanthine oxidase

21 January 2018

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Potent inhibition of human liver aldehyde oxidase by raloxifene

21 January 2018

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Human liver aldehyde oxidase: inhibition by 239 drugs

21 January 2018

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Increase of nicotinamide methyltransferase and N1-methyl-nicotinamide oxidase activities in the livers of the rats administered alkylating agents

21 January 2018

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The crystal structure of xanthine oxidoreductase during catalysis: implications for reaction mechanism and enzyme inhibition

21 January 2018

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Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

21 January 2018

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Early anti-oxidative and anti-proliferative curcumin effects on neuroglioma cells suggest therapeutic targets

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Identification and validation of commonly overexpressed genes in solid tumors by comparison of microarray data

21 January 2018

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Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers

21 January 2018

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The pathogenesis of molybdenum cofactor deficiency, its delay by maternal clearance, and its expression pattern in microarray analysis

21 January 2018

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X chromosomal abnormalities in basal-like human breast cancer

21 January 2018

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Identification of aldehyde oxidase 1 and aldehyde oxidase homologue 1 as dioxin-inducible genes.

21 January 2018

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Convergent neofunctionalization by positive Darwinian selection after ancient recurrent duplications of the xanthine dehydrogenase gene

21 January 2018

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Enzyme-catalyzed activation of anticancer prodrugs

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Influence of lipophilicity and carboxyl group content on the rate of hydroxylation of methotrexate derivatives by aldehyde oxidase

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Gene expression analyses reveal molecular relationships among 20 regions of the human CNS.

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Aldehyde oxidase activity and inhibition in hepatocytes and cytosolic fractions from mouse, rat, monkey and human

21 January 2018

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IPdR: a novel oral radiosensitizer

21 January 2018

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Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays.

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Site directed mutagenesis of amino acid residues at the active site of mouse aldehyde oxidase AOX1

21 January 2018

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Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia

21 January 2018

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A DNA microarray survey of gene expression in normal human tissues

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Human aldehyde oxidase 1 interacts with ATP-binding cassette transporter-1 and modulates its activity in hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Genetic studies of a cluster of acute lymphoblastic leukemia cases in Churchill County, Nevada

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Selection of DDX5 as a novel internal control for Q-RT-PCR from microarray data using a block bootstrap re-sampling scheme

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Estimation of aldehyde oxidase activity in vivo from conversion ratio of N1-methylnicotinamide to pyridones, and intraspecies variation of the enzyme activity in rats

21 January 2018

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Novel genes associated with malignant melanoma but not benign melanocytic lesions

21 January 2018

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Role of the molybdoflavoenzyme aldehyde oxidase homolog 2 in the biosynthesis of retinoic acid: generation and characterization of a knockout mouse

21 January 2018

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Avian and canine aldehyde oxidases. Novel insights into the biology and evolution of molybdo-flavoenzymes

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Isolation and characterization of the human aldehyde oxidase gene: conservation of intron/exon boundaries with the xanthine oxidoreductase gene indicates a common origin

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Purification of the aldehyde oxidase homolog 1 (AOH1) protein and cloning of the AOH1 and aldehyde oxidase homolog 2 (AOH2) genes. Identification of a novel molybdo-flavoprotein gene cluster on mouse chromosome 1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Cloning of the cDNAs coding for two novel molybdo-flavoproteins showing high similarity with aldehyde oxidase and xanthine oxidoreductase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Prognostically useful gene-expression profiles in acute myeloid leukemia.

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Regulation and biochemistry of mouse molybdo-flavoenzymes. The DBA/2 mouse is selectively deficient in the expression of aldehyde oxidase homologues 1 and 2 and represents a unique source for the purification and characterization of aldehyde oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Interactome-transcriptome analysis reveals the high centrality of genes differentially expressed in lung cancer tissues

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Tumor immunobiological differences in prostate cancer between African-American and European-American men.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Small-interference RNA-mediated knock-down of aldehyde oxidase 1 in 3T3-L1 cells impairs adipogenesis and adiponectin release

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Enzymes depending on the pterin molybdenum cofactor: sequence families, spectroscopic properties of molybdenum and possible cofactor-binding domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Activation of the human aldehyde oxidase (hAOX1) promoter by tandem cooperative Sp1/Sp3 binding sites: identification of complex architecture in the hAOX upstream DNA that includes a proximal promoter, distal activation sites, and a silencer element

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560606

High-resolution DNA copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomas

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Hereditary xanthinuria type II associated with mental delay, autism, cortical renal cysts, nephrocalcinosis, osteopenia, and hair and teeth defects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560606

In silico and in vitro pharmacogenetics: aldehyde oxidase rapidly metabolizes a p38 kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560606

Metabolism of methotrexate and γ-tert-butyl methotrexate by human leukemic cells in culture and by hepatic aldehyde oxidase in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2011.560606

10.3109/03602532.2011.560606

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference