(Q37861765)

24 August 2017

1 reference

title

Novel C-C chemokine receptor 2 antagonists in metabolic disease: a review of recent developments (English)

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24 August 2017

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Young Sun Kang

1

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24 August 2017

Jin Joo Cha

series ordinal

2

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24 August 2017

Young Youl Hyun

series ordinal

3

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24 August 2017

Dae Ryong Cha

series ordinal

4

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24 August 2017

language of work or name

English

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publication date

6 April 2011

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Expert Opinion on Investigational Drugs

24 August 2017

published in

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24 August 2017

volume

20

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24 August 2017

issue

6

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24 August 2017

page(s)

745-756

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Chemokines, leukocyte trafficking, and inflammation

24 August 2017

cites work

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21 January 2018

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Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails

21 January 2018

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Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells

21 January 2018

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Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant

21 January 2018

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Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE

21 January 2018

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Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones

21 January 2018

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High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR

21 January 2018

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Chemokines in rheumatic diseases

21 January 2018

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The many roles of chemokines and chemokine receptors in inflammation

21 January 2018

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The metabolic syndrome and adipocytokines

21 January 2018

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Obesity-induced inflammation: a metabolic dialogue in the language of inflammation

21 January 2018

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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

21 January 2018

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IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

21 January 2018

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CSF-1 regulation of the wandering macrophage: complexity in action

21 January 2018

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Innate immunity and adipose tissue biology

21 January 2018

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Regulation of IkappaBalpha function and NF-kappaB signaling: AEBP1 is a novel proinflammatory mediator in macrophages

21 January 2018

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CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

21 January 2018

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Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

21 January 2018

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Role of MCP-1 in cardiovascular disease: molecular mechanisms and clinical implications

21 January 2018

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Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

21 January 2018

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MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

21 January 2018

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Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance

21 January 2018

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Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue.

21 January 2018

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Monocyte chemoattractant protein deficiency fails to restrain macrophage infiltration into adipose tissue [corrected].

21 January 2018

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Monocyte chemoattractant protein 1 in obesity and insulin resistance

21 January 2018

1 reference

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An increase in the circulating concentration of monocyte chemoattractant protein-1 elicits systemic insulin resistance irrespective of adipose tissue inflammation in mice

21 January 2018

1 reference

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CCR2 modulates inflammatory and metabolic effects of high-fat feeding

21 January 2018

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Inflammation and insulin resistance

21 January 2018

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Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

21 January 2018

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Chemokines control fat accumulation and leptin secretion by cultured human adipocytes

21 January 2018

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CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice

21 January 2018

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C-C chemokine receptor 2 inhibitor improves diet-induced development of insulin resistance and hepatic steatosis in mice

21 January 2018

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Inhibition of CCR2 ameliorates insulin resistance and hepatic steatosis in db/db mice.

21 January 2018

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Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy

21 January 2018

1 reference

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Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Newly identified adipose tissue macrophage populations in obesity with distinct chemokine and chemokine receptor expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Role of CC chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue.

21 January 2018

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The role of GM-CSF in adipose tissue inflammation.

21 January 2018

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GM-CSF action in the CNS decreases food intake and body weight

21 January 2018

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Renal glucose production and utilization: new aspects in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Monocyte chemoattractant protein-1 induces proliferation and interleukin-6 production in human smooth muscle cells by differential activation of nuclear factor-kappaB and activator protein-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Effects of diabetes and hypertension on macrophage infiltration and matrix expansion in the rat kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Advanced glycation end product-induced apoptosis and overexpression of vascular endothelial growth factor and monocyte chemoattractant protein-1 in human-cultured mesangial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Chemokines in renal diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Blockade of CCR2 ameliorates progressive fibrosis in kidney.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Expression of functional CCR and CXCR chemokine receptors in podocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

MCP-1/CCR2 system is involved in high glucose-induced fibronectin and type IV collagen expression in cultured mesangial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Effect of the monocyte chemoattractant protein-1/CC chemokine receptor 2 system on nephrin expression in streptozotocin-treated mice and human cultured podocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Chemokine receptor antagonists: Part 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Chapter 12. The use of receptor homology modeling to facilitate the design of selective chemokine receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Pharmacological characterization of INCB3344, a small molecule antagonist of human CCR2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Protection against concanavalin A-induced murine liver injury by the organic germanium compound, propagermanium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

An anti-inflammatory drug, propagermanium, may target GPI-anchored proteins associated with an MCP-1 receptor, CCR2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Long-term treatment with propagermanium suppresses atherosclerosis in WHHL rabbits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Propagermanium suppresses macrophage-mediated formation of coronary arteriosclerotic lesions in pigs in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Propagermanium reduces atherosclerosis in apolipoprotein E knockout mice via inhibition of macrophage infiltration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Diet induction of monocyte chemoattractant protein-1 and its impact on obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Recent developments in CCR2 antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

4-Amino-2-alkyl-butyramides as small molecule CCR2 antagonists with favorable pharmacokinetic properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

CCR2B receptor antagonists: conversion of a weak HTS hit to a potent lead compound

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

CCR2: characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure-activity relationships of diamine derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

Monocyte chemoattractant protein-1 has prosclerotic effects both in a mouse model of experimental diabetes and in vitro in human mesangial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2011.575359

10.1517/13543784.2011.575359

21 January 2018

Identifiers

DOI

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24 August 2017

1 reference