(Q37867680)

24 August 2017

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title

Analysis of polar metabolites by hydrophilic interaction chromatography--MS/MS. (English)

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24 August 2017

Wenying Jian

1

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24 August 2017

Yaodong Xu

series ordinal

2

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24 August 2017

Richard W Edom

series ordinal

3

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24 August 2017

Naidong Weng

series ordinal

4

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24 August 2017

publication date

1 April 2011

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24 August 2017

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24 August 2017

volume

3

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24 August 2017

issue

8

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24 August 2017

page(s)

899-912

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Metabolites in safety testing (MIST): considerations of mechanisms of toxicity with dose, abundance, and duration of treatment

24 August 2017

cites work

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Which human metabolites have we MIST? Retrospective analysis, practical aspects, and perspectives for metabolite identification and quantification in pharmaceutical development.

21 January 2018

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Potential bias and mitigations when using stable isotope labeled parent drug as internal standard for LC-MS/MS quantitation of metabolites

21 January 2018

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Systematic LC-MS/MS bioanalytical method development that incorporates plasma phospholipids risk avoidance, usage of incurred sample and well thought-out chromatography

21 January 2018

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Bioanalytical liquid chromatography tandem mass spectrometry methods on underivatized silica columns with aqueous/organic mobile phases

21 January 2018

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Potential of HILIC-MS in quantitative bioanalysis of drugs and drug metabolites

21 January 2018

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Bioanalytical hydrophilic interaction chromatography: recent challenges, solutions and applications

21 January 2018

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Recent advances in application of hydrophilic interaction chromatography for quantitative bioanalysis

21 January 2018

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Stationary phases for hydrophilic interaction chromatography, their characterization and implementation into multidimensional chromatography concepts

21 January 2018

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Hydrophilic interaction chromatography

21 January 2018

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Retention behavior of small polar compounds on polar stationary phases in hydrophilic interaction chromatography

21 January 2018

1 reference

Direct injection of solid-phase extraction eluents onto silica columns for the analysis of polar compounds isoniazid and cetirizine in plasma using hydrophilic interaction chromatography with tandem mass spectrometry

21 January 2018

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Direct injection of 96-well organic extracts onto a hydrophilic interaction chromatography/tandem mass spectrometry system using a silica stationary phase and an aqueous/organic mobile phase

21 January 2018

1 reference

A 96-well single-pot liquid-liquid extraction, hydrophilic interaction liquid chromatography-mass spectrometry method for the determination of muraglitazar in human plasma

21 January 2018

1 reference

Analysis of omeprazole and 5-OH omeprazole in human plasma using hydrophilic interaction chromatography with tandem mass spectrometry (HILIC-MS/MS)--eliminating evaporation and reconstitution steps in 96-well liquid/liquid extraction

21 January 2018

1 reference

Liquid chromatography/tandem mass spectrometric bioanalysis using normal-phase columns with aqueous/organic mobile phases - a novel approach of eliminating evaporation and reconstitution steps in 96-well SPE.

21 January 2018

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Ultrafast liquid chromatography/tandem mass spectrometry bioanalysis of polar analytes using packed silica columns

21 January 2018

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Fast hydrophilic interaction liquid chromatographic separations on bonded zwitterionic stationary phase

21 January 2018

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Ultra-performance hydrophilic interaction liquid chromatography/tandem mass spectrometry for the determination of everolimus in mouse plasma

21 January 2018

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Chromatographic behavior of epirubicin and its analogues on high-purity silica in hydrophilic interaction chromatography

21 January 2018

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Properties of acyl glucuronides: implications for studies of the pharmacokinetics and metabolism of acidic drugs

21 January 2018

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Morphine-6beta-glucuronide and morphine-3-glucuronide, opioid receptor agonists with different potencies

21 January 2018

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Metabonomics and biomarker discovery: LC-MS metabolic profiling and constant neutral loss scanning combined with multivariate data analysis for mercapturic acid analysis

21 January 2018

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Rapid detection and identification of N-acetyl-L-cysteine thioethers using constant neutral loss and theoretical multiple reaction monitoring combined with enhanced product-ion scans on a linear ion trap mass spectrometer.

21 January 2018

1 reference

Rapid and sensitive HILIC-ESI-MS/MS quantitation of polar metabolites of acrylamide in human urine using column switching with an online trap column

21 January 2018

1 reference

Determination of six hydroxyalkyl mercapturic acids in human urine using hydrophilic interaction liquid chromatography with tandem mass spectrometry (HILIC-ESI-MS/MS).

21 January 2018

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Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine

21 January 2018

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Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development

21 January 2018

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Negative ion tandem mass spectrometry for the detection of glutathione conjugates

21 January 2018

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Recent advances in applications of liquid chromatography-tandem mass spectrometry to the analysis of reactive drug metabolites

21 January 2018

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Rapid detection and characterization of in vitro and urinary N-acetyl-L-cysteine conjugates using quadrupole-linear ion trap mass spectrometry and polarity switching.

21 January 2018

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Nuclear magnetic resonance spectroscopy as a quantitative tool to determine the concentrations of biologically produced metabolites: implications in metabolites in safety testing

21 January 2018

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Obtaining exposures of metabolites in preclinical species through plasma pooling and quantitative NMR: addressing metabolites in safety testing (MIST) guidance without using radiolabeled compounds and chemically synthesized metabolite standards.

21 January 2018

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An automatic 96-well solid phase extraction and liquid chromatography-tandem mass spectrometry method for the analysis of morphine, morphine-3-glucuronide and morphine-6-glucuronide in human plasma

21 January 2018

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On-line desalting and determination of morphine, morphine-3-glucuronide and morphine-6-glucuronide in microdialysis and plasma samples using column switching and liquid chromatography/tandem mass spectrometry

21 January 2018

1 reference

Hydrophilic interaction liquid chromatography and accurate mass measurement for quantification and confirmation of morphine, codeine and their glucuronide conjugates in human urine

21 January 2018

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Hydrophilic interaction liquid chromatography-tandem mass spectrometry determination of estrogen conjugates in human urine

21 January 2018

1 reference

Column-switching reversed phase-hydrophilic interaction liquid chromatography/tandem mass spectrometry method for determination of free estrogens and their conjugates in river water

21 January 2018

1 reference

On-line desorption of dried blood spots coupled to hydrophilic interaction/reversed-phase LC/MS/MS system for the simultaneous analysis of drugs and their polar metabolites

21 January 2018

1 reference

Hydrophilic interaction chromatography coupled to MS for metabonomic/metabolomic studies

21 January 2018

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Metabolomic applications of HILIC-LC-MS.

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/BIO.11.51

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24 August 2017

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