(Q37868574)

24 August 2017

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title

Translating promising preclinical neuroprotective therapies to human stroke trials (English)

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24 August 2017

Douglas James Cook

1

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PubMed ID

21517728

24 August 2017

Michael Tymianski

series ordinal

2

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24 August 2017

1 April 2011

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Expert Review of Cardiovascular Therapy

24 August 2017

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24 August 2017

9

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24 August 2017

4

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24 August 2017

433-449

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Heart Disease and Stroke Statistics--2010 Update: A Report From the American Heart Association

24 August 2017

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Costs and rehabilitation use of stroke survivors: a retrospective study of Medicare beneficiaries

21 January 2018

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Trends in acute ischemic stroke trials through the 20th century

21 January 2018

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Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions

21 January 2018

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1,026 experimental treatments in acute stroke

21 January 2018

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Rodent models of focal stroke: size, mechanism, and purpose

21 January 2018

1 reference

Pharmacological approaches to stroke recovery

21 January 2018

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Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia

21 January 2018

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Pooling of animal experimental data reveals influence of study design and publication bias

21 January 2018

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Recommendations for standards regarding preclinical neuroprotective and restorative drug development

21 January 2018

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Update of the stroke therapy academic industry roundtable preclinical recommendations

21 January 2018

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21 January 2018

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NXY-059: a hopeful sign in the treatment of stroke

21 January 2018

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Assessment of cognitive and motor deficits in a marmoset model of stroke

21 January 2018

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Serial MRI, functional recovery, and long-term infarct maturation in a non-human primate model of stroke

21 January 2018

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NXY-059, a free radical--trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species

21 January 2018

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Functional and histological evidence for the protective effect of NXY-059 in a primate model of stroke when given 4 hours after occlusion

21 January 2018

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Comparison of the neuroprotective effect of clomethiazole, AR-R15896AR and NXY-059 in a primate model of stroke using histological and behavioural measures

21 January 2018

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NXY-059 for acute ischemic stroke

21 January 2018

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NXY-059 for the treatment of acute stroke: pooled analysis of the SAINT I and II Trials

21 January 2018

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Bench to bedside: the quest for quality in experimental stroke research

21 January 2018

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Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials

21 January 2018

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Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials

21 January 2018

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A critical appraisal of the NXY-059 neuroprotection studies for acute stroke: a need for more rigorous testing of neuroprotective agents in animal models of stroke

21 January 2018

1 reference

Glucose deprivation induces mitochondrial dysfunction and oxidative stress in PC12 cell line.

21 January 2018

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Quantitative measurement of neuronal degeneration in organotypic hippocampal cultures after combined oxygen/glucose deprivation.

21 January 2018

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Organotypic cultures as tools for functional screening in the CNS.

21 January 2018

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Oxidative stress and cyclooxygenase-2 induction mediate cyanide-induced apoptosis of cortical cells

21 January 2018

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Glutamate receptors, neurotoxicity and neurodegeneration

21 January 2018

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Calcium, ischemia and excitotoxicity.

21 January 2018

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AMPA receptor mediated excitotoxicity in neocortical neurons is developmentally regulated and dependent upon receptor desensitization.

21 January 2018

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The use of propidium iodide to assess excitotoxic neuronal death in primary mixed cortical cultures

21 January 2018

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Ischemia-induced neuronal apoptosis

21 January 2018

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A novel in vitro ischemia/reperfusion injury model.

21 January 2018

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Cell-cell signaling in the neurovascular unit

21 January 2018

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Comparison of two blood-brain barrier in vitro systems: cytotoxicity and transfer assessments of malathion/oxon and lead acetate.

21 January 2018

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Organotypic hippocampal slice cultures: a model system to study basic cellular and molecular mechanisms of neuronal cell death, neuroprotection, and synaptic plasticity

21 January 2018

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Organotypic hippocampal slice cultures for studies of brain damage, neuroprotection and neurorepair

21 January 2018

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Mechanisms of neural cell death: implications for development of neuroprotective treatment strategies

21 January 2018

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Neuroprotective gene therapy against acute neurological insults

21 January 2018

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In vivo gene regulation using tetracycline-regulatable systems

21 January 2018

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Ischaemic brain damage after stroke: new insights into efficient therapeutic strategies. International Symposium on Neurodegeneration and Neuroprotection

21 January 2018

1 reference

Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein

21 January 2018

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Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions

21 January 2018

1 reference

Rodent models of focal cerebral ischemia: procedural pitfalls and translational problems

21 January 2018

1 reference

Animal models of acute ischaemic stroke: can they predict clinically successful neuroprotective drugs?

21 January 2018

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Why have so many drugs with stellar results in laboratory stroke models failed in clinical trials? A theory based on allometric relationships

21 January 2018

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Lost in translation: taking neuroprotection from animal models to clinical trials.

21 January 2018

1 reference

Pathophysiology of stroke: lessons from animal models

21 January 2018

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Permanent or transient chronic ischemic stroke in the non-human primate: behavioral, neuroimaging, histological, and immunohistochemical investigations

21 January 2018

1 reference

Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.

21 January 2018

1 reference

Reversible middle cerebral artery occlusion without craniectomy in rats

21 January 2018

1 reference

Evaluation of MCAO stroke models in normotensive rats: standardized neocortical infarction by the 3VO technique

21 January 2018

1 reference

Infarct volume as a surrogate or auxiliary outcome measure in ischemic stroke clinical trials. The RANTTAS Investigators

21 January 2018

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Functional assessments in the rodent stroke model

21 January 2018

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Cognitive and behavioral assessment in experimental stroke research: will it prove useful?

21 January 2018

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Paw-reaching, sensorimotor, and rotational behavior after brain infarction in rats.

21 January 2018

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A comparison of long-term functional outcome after 2 middle cerebral artery occlusion models in rats.

21 January 2018

1 reference

Neuroprotection for ischemic stroke: two decades of success and failure

21 January 2018

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Rodent models of cerebral ischemia

21 January 2018

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Do in vivo experimental models reflect human cerebral small vessel disease? A systematic review.

21 January 2018

1 reference

Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke

21 January 2018

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Methodological quality of preclinical stroke studies is not required for publication in high-impact journals

21 January 2018

1 reference

Primate phylogeny: molecular evidence from retroposons

21 January 2018

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The development of stroke therapeutics: promising mechanisms and translational challenges

21 January 2018

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Serial magnetic resonance imaging in experimental primate stroke: validation of MRI for pre-clinical cerebroprotective trials

21 January 2018

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A modified transorbital baboon model of reperfused stroke

21 January 2018

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Experimental acute thrombotic stroke in baboons.

21 January 2018

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An improved functional neurological examination for use in nonhuman primate studies of focal reperfused cerebral ischemia.

21 January 2018

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Extending reperfusion therapy for acute ischemic stroke: emerging pharmacological, mechanical, and imaging strategies.

21 January 2018

1 reference

Preclinical evaluation of the neuroprotective effect of soluble complement receptor type 1 in a nonhuman primate model of reperfused stroke.

21 January 2018

1 reference

HuEP5C7 as a humanized monoclonal anti-E/P-selectin neurovascular protective strategy in a blinded placebo-controlled trial of nonhuman primate stroke.

21 January 2018

1 reference

Chronic ischemic stroke model in cynomolgus monkeys: behavioral, neuroimaging and anatomical study

21 January 2018

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A new model of cortical stroke in the rhesus macaque.

21 January 2018

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Neuroimaging and histopathological evaluation of delayed neurological damage produced by artificial occlusion of the middle cerebral artery in Cynomolgus monkeys: establishment of a monkey model for delayed cerebral ischemia.

21 January 2018

1 reference

Characterization of a novel thrombotic middle cerebral artery occlusion model in monkeys that exhibits progressive hypoperfusion and robust cortical infarction.

21 January 2018

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Neuroprotective action of tacrolimus (FK506) in focal and global cerebral ischemia in rodents: dose dependency, therapeutic time window and long-term efficacy

21 January 2018

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Therapeutic time window of tacrolimus (FK506) in a nonhuman primate stroke model: comparison with tissue plasminogen activator.

21 January 2018

1 reference

Ginsenoside Rb1 reduces neurodegeneration in the peri-infarct area of a thromboembolic stroke model in non-human primates

21 January 2018

1 reference

Seroprevalence of Toxoplasma gondii in bred cynomolgus monkeys ( Macaca fascicularis ) in China

21 January 2018

1 reference

Liposome-encapsulated hemoglobin ameliorates ischemic stroke in nonhuman primates: an acute study

21 January 2018

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Translational research: moving discovery to practice.

21 January 2018

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A matching algorithm to address imbalances in study populations: application to the National Institute of Neurological Diseases and Stroke Recombinant Tissue Plasminogen Activator acute stroke trial.

21 January 2018

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Optimizing cutoff scores for the Barthel index and the modified Rankin scale for defining outcome in acute stroke trials

21 January 2018

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Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach.

21 January 2018

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What are surrogate outcome measures and why do they fail in clinical research?

21 January 2018

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Correlating tissue outcome with quantitative multiparametric MRI of acute cerebral ischemia in rats

21 January 2018

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Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats.

21 January 2018

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Experimental stroke in gerbils: effect on translation and transcription

21 January 2018

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MAP2 immunostaining in thick sections for early ischemic stroke infarct volume in non-human primate brain

21 January 2018

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A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. II. Volume of distribution and mean residence time.

21 January 2018

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Middle cerebral artery occlusion in Macaca fascicularis: acute and chronic stroke evolution.

21 January 2018

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Experimental thromboembolic stroke in cynomolgus monkey.

21 January 2018

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Serial changes in cerebral blood flow and flow-metabolism uncoupling in primates with acute thromboembolic stroke

21 January 2018

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Bioethical considerations in translational research: primate stroke

21 January 2018

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Considerations in the design of clinical trials of neuroprotective therapy in acute stroke

21 January 2018

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Fetal striatal allografts reverse cognitive deficits in a primate model of Huntington disease

21 January 2018

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Patterns of cognitive decline in aged rhesus monkeys.

21 January 2018

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Impairment in abstraction and set shifting in aged rhesus monkeys.

21 January 2018

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Cerebrovascular disease and dementia: a primate model of hypertension and cognition.

21 January 2018

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Neuroprotection does not work!

21 January 2018

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Good laboratory practice: preventing introduction of bias at the bench

21 January 2018

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Acute stroke therapy with tissue plasminogen activator (tPA) since it was approved by the U.S. Food and Drug Administration (FDA).

21 January 2018

1 reference

Efficacy and safety of tissue plasminogen activator 3 to 4.5 hours after acute ischemic stroke: a metaanalysis.

21 January 2018

1 reference

Local Cerebral Blood Flow and Vascular Reactivity in a Chronic Stable Stroke in Baboons

21 January 2018

1 reference

Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia

21 January 2018

1 reference

Optimal definition for PWI/DWI mismatch in acute ischemic stroke patients

21 January 2018

1 reference

Relationships between infarct growth, clinical outcome, and early recanalization in diffusion and perfusion imaging for understanding stroke evolution (DEFUSE)

21 January 2018

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Optimal outcome measures for detecting clinical benefits of early reperfusion: insights from the DEFUSE Study.

21 January 2018

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New light on white matter.

21 January 2018

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Ischemic thresholds for gray and white matter: a diffusion and perfusion magnetic resonance study.

21 January 2018

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The rise and fall of NMDA antagonists for ischemic stroke.

21 January 2018

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The existence and evolution of diffusion-perfusion mismatched tissue in white and gray matter after acute stroke.

21 January 2018

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Drug development for stroke: importance of protecting cerebral white matter

21 January 2018

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Combination therapy with hypothermia for treatment of cerebral ischemia

21 January 2018

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Combination drug therapy and mild hypothermia: a promising treatment strategy for reversible, focal cerebral ischemia.

21 January 2018

1 reference

Combination treatment for acute ischemic stroke: A ray of Hope?

21 January 2018

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Combined neuroprotective modalities coupled with thrombolysis in acute ischemic stroke: a pilot study of caffeinol and mild hypothermia

21 January 2018

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PDZ Protein Interactions Underlying NMDA Receptor-Mediated Excitotoxicity and Neuroprotection by PSD-95 Inhibitors

21 January 2018

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21 January 2018

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Rat middle cerebral artery occlusion: Correlations between histopathology, T2-weighted magnetic resonance imaging, and behavioral indices

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1586/ERC.11.34

1 reference

24 August 2017

1 reference

PubMed ID

21517728