(Q37868927)

24 August 2017

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title

Interleukin-33 biology with potential insights into human diseases (English)

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24 August 2017

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2

Cem Gabay

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24 August 2017

Gaby Palmer

1

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24 August 2017

language of work or name

English

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publication date

26 April 2011

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Nature Reviews Rheumatology

24 August 2017

published in

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24 August 2017

volume

7

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24 August 2017

issue

6

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24 August 2017

page(s)

321-329

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https://scigraph.springernature.com/pub.10.1038/nrrheum.2011.53

24 August 2017

exact match

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cites work

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocket

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Interleukin-33 is biologically active independently of caspase-1 cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 is a crucial amplifier of innate rather than acquired immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Inflammatory bowel disease-associated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Caspase-1, Caspase-8, and Calpain Are Dispensable for IL-33 Release by Macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Mature interleukin-33 is produced by calpain-mediated cleavage in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Caspase 3 inactivates biologically active full length interleukin-33 as a classical cytokine but does not prohibit nuclear translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Expression and regulation of interleukin-33 in human monocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Increased levels of interleukin 33 in sera and synovial fluid from patients with active rheumatoid arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Interleukin-33 - cytokine of dual function or novel alarmin?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Induction of IL-33 expression and activity in central nervous system glia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Active caspase-1 is a regulator of unconventional protein secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Increased IL-33 expression by epithelial cells in bronchial asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Treatment-recalcitrant chronic rhinosinusitis with polyps is associated with altered epithelial cell expression of interleukin-33.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 and IL-33 receptors in host defense and diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

T1/ST2--an IL-1 receptor-like modulator of immune responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

The cloning and nucleotide sequence of human ST2L cDNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Murine ST2 gene is a member of the primary response gene family induced by growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Expression of ST2, an interleukin-1 receptor homologue, is induced by proinflammatory stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Tissue Distribution and Subcellular Localization of a Variant Form of the Human ST2 Gene Product, ST2V

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

The IL-1 receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 mediates inflammatory responses in human lung tissue cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Intracellular signaling mechanisms regulating the activation of human eosinophils by the novel Th2 cytokine IL-33: implications for allergic inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Modulation of interleukin signalling and gene expression in cardiac myocytes by endothelin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

KU812 cells provide a novel in vitro model of the human IL-33/ST2L axis: functional responses and identification of signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

TRAF6 is a critical signal transducer in IL-33 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

JAK2 is an important signal transducer in IL-33-induced NF-κB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

The essential role of single Ig IL-1 receptor-related molecule/Toll IL-1R8 in regulation of Th2 immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Interleukin-33 stimulates formation of functional osteoclasts from human CD14(+) monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

A signal-switch hypothesis for cross-regulation of cytokine and TLR signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

The biological paths of IL-1 family members IL-18 and IL-33.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 can promote survival, adhesion and cytokine production in human mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Interleukin (IL)-33 induces the release of pro-inflammatory mediators by mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 is a chemoattractant for human Th2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

A novel IL-1 family cytokine, IL-33, potently activates human eosinophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 activates unprimed murine basophils directly in vitro and induces their in vivo expansion indirectly by promoting hematopoietic growth factor production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33-activated dendritic cells induce an atypical TH2-type response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 enhances lipopolysaccharide-induced inflammatory cytokine production from mouse macrophages by regulating lipopolysaccharide receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-gamma production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

A novel method for procuring a large quantity of mature murine eosinophils in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33, a potent inducer of adaptive immunity to intestinal nematodes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

The cytokine interleukin-33 mediates anaphylactic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 prolongs murine cardiac allograft survival through induction of TH2-type immune deviation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 shifts macrophage polarization, promoting resistance against Pseudomonas aeruginosa keratitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 exacerbates antigen-induced arthritis by activating mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 mediates antigen-induced cutaneous and articular hypernociception in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 exacerbates autoantibody-induced arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Nuclear expression of interleukin-33 in pancreatic stellate cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

A novel therapy of murine collagen-induced arthritis with soluble T1/ST2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 is expressed in human osteoblasts, but has no direct effect on bone remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 receptor (T1/ST2) signalling is necessary to prevent the development of encephalitis in mice infected with Toxoplasma gondii.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 reduces the development of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 reduces macrophage foam cell formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Serum levels of IL-33 and soluble ST2 and their association with disease activity in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Increased levels of soluble ST2 protein and IgG1 production in patients with sepsis and trauma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Serum levels of the interleukin-1 receptor family member ST2 predict mortality and clinical outcome in acute myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

ST2: a novel remodeling biomarker in acute and chronic heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Soluble ST2 plasma concentrations predict mortality in severe sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Alarmins: chemotactic activators of immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

CD34+ hemopoietic progenitor cells are potent effectors of allergic inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Interleukin-33 is expressed in differentiated osteoblasts and blocks osteoclast formation from bone marrow precursor cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Contribution of IL-33 to induction and augmentation of experimental allergic conjunctivitis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 induces IL-13-dependent cutaneous fibrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

IL-33 Exacerbates Eosinophil-Mediated Airway Inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

T1/ST2 expression on Th2 cells negatively regulates allergic pulmonary inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Over-expression of IL-33 leads to spontaneous pulmonary inflammation in mIL-33 transgenic mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Interleukin-33, a target of parathyroid hormone and oncostatin m, increases osteoblastic matrix mineral deposition and inhibits osteoclast formation in vitro

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Interleukin-33 prevents apoptosis and improves survival after experimental myocardial infarction through ST2 signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Association of serum interleukin-33 level and the interleukin-33 genetic variant with Japanese cedar pollinosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Elevated Serum Interleukin 33 Is Associated with Autoantibody Production in Patients with Rheumatoid Arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Distinct serum and synovial fluid interleukin (IL)-33 levels in rheumatoid arthritis, psoriatic arthritis and osteoarthritis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Association of increased serum IL-33 levels with clinical and laboratory characteristics of systemic lupus erythematosus in Chinese population

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

The IL1-like cytokine IL33 and its receptor ST2 are abnormally expressed in the affected skin and visceral organs of patients with systemic sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Increased serum levels of soluble ST2 in birch pollen atopics and individuals working in laboratory animal facilities

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.53

Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21519352

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRRHEUM.2011.53

1 reference

24 August 2017

1 reference