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A clinical perspective of IL-1β as the gatekeeper of inflammation
scientific article published on May 2011
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
21523780
retrieved
24 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
A clinical perspective of IL-1β as the gatekeeper of inflammation
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
21523780
retrieved
24 August 2017
main subject
inflammation
0 references
author
Charles A. Dinarello
series ordinal
1
object named as
Charles A Dinarello
1 reference
stated in
Europe PubMed Central
PubMed ID
21523780
retrieved
24 August 2017
language of work or name
English
0 references
publication date
1 May 2011
1 reference
stated in
Europe PubMed Central
PubMed ID
21523780
retrieved
24 August 2017
published in
European Journal of Immunology
1 reference
stated in
Europe PubMed Central
PubMed ID
21523780
retrieved
24 August 2017
volume
41
1 reference
stated in
Europe PubMed Central
PubMed ID
21523780
retrieved
24 August 2017
issue
5
1 reference
stated in
Europe PubMed Central
PubMed ID
21523780
retrieved
24 August 2017
page(s)
1203-1217
1 reference
stated in
Europe PubMed Central
PubMed ID
21523780
retrieved
24 August 2017
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Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies
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Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade
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Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta
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ATP acts as an agonist to promote stimulus-induced secretion of IL-1 beta and IL-18 in human blood
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Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis
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Use of canakinumab in the cryopyrin-associated periodic syndrome
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Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: Results of a multicenter, phase II, dose-ranging study
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Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation
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Crossref
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1 reference
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Crossref
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Neurologic manifestations of the cryopyrin-associated periodic syndrome.
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1 reference
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1 reference
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Crossref
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Role of interleukin-6 in a patient with tumor necrosis factor receptor-associated periodic syndrome: assessment of outcomes following treatment with the anti-interleukin-6 receptor monoclonal antibody tocilizumab.
1 reference
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Crossref
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7 January 2021
based on heuristic
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Blocking the effects of IL-1 in rheumatoid arthritis protects bone and cartilage.
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Clinical and radiological effects of anakinra in patients with rheumatoid arthritis
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7 January 2021
based on heuristic
inferred from DOI database lookup
Anakinra for rheumatoid arthritis: a systematic review
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
An open-label pilot study of the efficacy and safety of anakinra in patients with psoriatic arthritis refractory to or intolerant of methotrexate (MTX).
1 reference
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7 January 2021
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1 reference
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7 January 2021
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Interleukin-18 promotes joint inflammation and induces interleukin-1-driven cartilage destruction
1 reference
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7 January 2021
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Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study
1 reference
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7 January 2021
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Isolation of an interleukin-1-like factor from human joint effusions
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7 January 2021
based on heuristic
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MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Gout-associated uric acid crystals activate the NALP3 inflammasome
1 reference
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reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1 beta by mononuclear cells through a caspase 1-mediated process
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta
1 reference
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7 January 2021
based on heuristic
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IL-1 inhibition with anakinra in a patient with refractory gout
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https://api.crossref.org/works/10.1002%2FEJI.201141550
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7 January 2021
based on heuristic
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A pilot study of IL-1 inhibition by anakinra in acute gout
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7 January 2021
based on heuristic
inferred from DOI database lookup
Update on gout: new therapeutic strategies and options
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7 January 2021
based on heuristic
inferred from DOI database lookup
The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study
1 reference
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Crossref
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https://api.crossref.org/works/10.1002%2FEJI.201141550
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7 January 2021
based on heuristic
inferred from DOI database lookup
Successful treatment of chronic tophaceous gout with infliximab (Remicade)
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans
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7 January 2021
based on heuristic
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Cytokines and beta-cell biology: from concept to clinical translation
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7 January 2021
based on heuristic
inferred from DOI database lookup
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets
1 reference
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7 January 2021
based on heuristic
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The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity
1 reference
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7 January 2021
based on heuristic
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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
1 reference
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7 January 2021
based on heuristic
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Disease-associated amyloid and misfolded protein aggregates activate the inflammasome
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7 January 2021
based on heuristic
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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
1 reference
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based on heuristic
inferred from DOI database lookup
Interleukin-1-receptor antagonist in type 2 diabetes mellitus
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Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes.
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes.
1 reference
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reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-1beta modulation using a genetically engineered antibody prevents adverse cardiac remodelling following acute myocardial infarction in the mouse
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot study).
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Anakinra, a recombinant human interleukin-1 receptor antagonist, inhibits apoptosis in experimental acute myocardial infarction.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
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7 January 2021
based on heuristic
inferred from DOI database lookup
Clinical Course and Prognosis of Smoldering (Asymptomatic) Multiple Myeloma
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7 January 2021
based on heuristic
inferred from DOI database lookup
The role of interleukin-1 beta in the pathogenesis of multiple myeloma
1 reference
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reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of a chronic disease state in patients with smoldering or indolent multiple myeloma by targeting interleukin 1{beta}-induced interleukin 6 production and the myeloma proliferative component
1 reference
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reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
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7 January 2021
based on heuristic
inferred from DOI database lookup
The Schnitzler syndrome
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7 January 2021
based on heuristic
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Successful treatment of Castleman's disease with interleukin-1 receptor antagonist (Anakinra).
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phase I trial of escalating doses of interleukin-1 beta in combination with a fixed dose of interleukin-2.
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of interleukin-1 alpha on carboplatin-induced thrombocytopenia in patients with recurrent ovarian cancer
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of interleukin-1 alpha on ovarian carcinoma in patients with recurrent disease.
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7 January 2021
based on heuristic
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Phase II trial of interleukin 1 alpha and indomethacin in treatment of metastatic melanoma
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7 January 2021
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The effects of treatment with interleukin-1 alpha on platelet recovery after high-dose carboplatin
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Induction of circulating soluble tumour necrosis factor receptor and interleukin 1 receptor antagonist following interleukin 1 alpha infusion in humans
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based on heuristic
inferred from DOI database lookup
The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-1 targeting drugs in familial Mediterranean fever: a case series and a review of the literature
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anti-interleukin 1 treatment for patients with familial Mediterranean fever resistant to colchicine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transmission of familial Mediterranean fever mutation after bone marrow transplantation and successful treatment with anakinra
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted treatment of pyoderma gangrenosum in PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) syndrome with the recombinant human interleukin-1 receptor antagonist anakinra
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anakinra for flares of pyogenic arthritis in PAPA syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cryopyrin-associated periodic syndrome: an autoinflammatory disease manifested as neutrophilic urticarial dermatosis with additional perieccrine involvement.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Efficacy and safety of anakinra therapy in pediatric and adult patients with the autoinflammatory Muckle-Wells syndrome.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Follow-up and quality of life of patients with cryopyrin-associated periodic syndromes treated with Anakinra.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Long-term efficacy of the interleukin-1 receptor antagonist anakinra in ten patients with neonatal-onset multisystem inflammatory disease/chronic infantile neurologic, cutaneous, articular syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Treatment with anakinra in the hyperimmunoglobulinemia D/periodic fever syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anakinra is safe and effective in controlling hyperimmunoglobulinaemia D syndrome-associated febrile crisis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A case of refractory adult-onset Still's disease treated with anakinra
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
May anakinra be used earlier in adult onset Still disease?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IL1-receptor antagonist anakinra provides long-lasting efficacy in the treatment of refractory adult-onset Still's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset Still disease: preliminary experience in France
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anakinra treatment for systemic onset juvenile idiopathic arthritis (SOJIA)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anakinra therapy in a child with systemic-onset juvenile rheumatoid arthritis after human herpesvirus 6 encephalitis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adult-onset Still's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adult-onset Still's disease with myocarditis successfully treated with the interleukin-1 receptor antagonist anakinra
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anakinra as first-line disease-modifying therapy in systemic juvenile idiopathic arthritis: report of forty-six patients from an international multicenter series
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Beneficial response to anakinra and thalidomide in Schnitzler's syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Schnitzler syndrome: treatment failure to rituximab but response to anakinra
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Successful treatment of idiopathic recurrent pericarditis in children with interleukin-1beta receptor antagonist (anakinra): an unrecognized autoinflammatory disease?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A case of macrophage activation syndrome successfully treated with anakinra
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A 36-year-old woman with recurrent high-grade fevers, hypotension, and hypertriglyceridemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Non‐complementaemic urticarial vasculitis: successful treatment with the IL‐1 receptor antagonist, anakinra
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antisynthetase syndrome with refractory polyarthritis and fever successfully treated with the IL-1 receptor antagonist, anakinra: A case report
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
[Indications of anakinra]
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Resistant Behçet disease responsive to anakinra
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rationale and efficacy of interleukin-1 targeting in Erdheim-Chester disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dysregulation of P2X7 receptor-inflammasome axis in SAPHO syndrome: successful treatment with anakinra
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) is a disorder of innate immunity and Th1 activation responsive to IL-1 blockade
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Case of anakinra as a steroid-sparing agent for gout inflammation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Management of treatment resistant inflammation of acute on chronic tophaceous gout with anakinra
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.201141550
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1002/EJI.201141550
1 reference
stated in
Europe PubMed Central
PubMed ID
21523780
retrieved
24 August 2017
PubMed ID
21523780
1 reference
stated in
Europe PubMed Central
PubMed ID
21523780
retrieved
24 August 2017
ResearchGate publication ID
51080496
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