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The identification of and rationale for drugs which act at the motilin receptor.
scientific article published on January 2009
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Europe PubMed Central
PubMed publication ID
21544957
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21544957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
review article
1 reference
stated in
Europe PubMed Central
title
The identification of and rationale for drugs which act at the motilin receptor
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21544957
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21544957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
author
Gareth Sanger
series ordinal
2
1 reference
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Europe PubMed Central
PubMed publication ID
21544957
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21544957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
author name string
Susan M Westaway
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21544957
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21544957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
publication date
1 January 2009
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21544957
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21544957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
published in
Progress in medicinal chemistry
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21544957
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21544957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
volume
48
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21544957
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21544957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
page(s)
31-80
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21544957
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21544957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
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7 January 2021
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Motilin, ghrelin and related neuropeptides as targets for the treatment of GI diseases.
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Motility disorders in the ICU: recent therapeutic options and clinical practice
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Efficacy of prolonged administration of intravenous erythromycin in an ambulatory setting as treatment of severe gastroparesis: one center's experience
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7 January 2021
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Erythromycin improves glycaemic control in patients with Type II diabetes mellitus.
1 reference
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
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The rabbit motilin receptor: molecular characterisation and pharmacology.
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7 January 2021
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Molecular characterization and distribution of motilin family receptors in the human gastrointestinal tract
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7 January 2021
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Differences between the abilities of tegaserod and motilin receptor agonists to stimulate gastric motility in vitro.
1 reference
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Crossref
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7 January 2021
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Involvement of two different pathways in the motor effects of erythromycin on the gastric antrum in humans
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7 January 2021
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Erythromycin accelerates gastric emptying in a dose-response manner in healthy subjects
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
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Influence of motilin on gastric fundus tone and on meal-induced satiety in man: role of cholinergic pathways.
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Crossref
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
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GSK962040: a small molecule, selective motilin receptor agonist, effective as a stimulant of human and rabbit gastrointestinal motility
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Crossref
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
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Differential determinants for peptide and non-peptidyl ligand binding to the motilin receptor. Critical role of second extracellular loop for peptide binding and action
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
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Effect of erythromycin on pancreatic polypeptide release: role of the vagal nerve
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7 January 2021
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Effect of antrectomy and truncal vagotomy on erythromycin induced pancreatic polypeptide secretion
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
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Effect of motilin on endogenous release of insulin in conscious dogs in the fed state
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
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Macrolides with gastrointestinal motor stimulating activity
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reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Erythromycin and its derivatives with motilin-like biological activities inhibit the specific binding of 125I-motilin to duodenal muscle
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
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inferred from DOI database lookup
Motilides, macrolides with gastrointestinal motor stimulating activity. I. O-substituted and tertiary N-substituted derivatives of 8,9-anhydroerythromycin A 6,9-hemiacetal
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Crossref
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7 January 2021
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Motilides, macrolides with gastrointestinal motor stimulating activity. II. Quaternary N-substituted derivatives of 8,9-anhydroerythromycin A 6,9-hemiacetal and 9,9-dihydroerythromycin A 6,9-epoxide
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7 January 2021
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inferred from DOI database lookup
The erythromycin derivative EM-523 is a potent motilin agonist in man and in rabbit
1 reference
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7 January 2021
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Mechanism of gastroprokinetic effect of EM523, an erythromycin derivative, in dogs
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7 January 2021
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Stimulatory mechanism of EM523-induced contractions in postprandial stomach of conscious dogs
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7 January 2021
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Effect of erythromycin derivative EM523L on human interdigestive gastrointestinal tract
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7 January 2021
based on heuristic
inferred from DOI database lookup
EM523L, a nonpeptide motilin agonist, stimulates gastric emptying and pancreatic polypeptide secretion
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
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EM574, an erythromycin derivative, is a motilin receptor agonist in the rabbit
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
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Vagus-dependent and vagus-independent mechanisms of action of the erythromycin derivative EM574 and motilin in dogs
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7 January 2021
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Motilides: a long and winding road: lessons from mitemcinal (GM-611) on diabetic gastroparesis
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7 January 2021
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Efficacy of mitemcinal, a motilin agonist, on gastrointestinal symptoms in patients with symptoms suggesting diabetic gastropathy: a randomized, multi-center, placebo-controlled trial
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
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inferred from DOI database lookup
Synthesis of 4"-deoxy motilides: identification of a potent and orally active prokinetic drug candidate
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
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inferred from DOI database lookup
Effects of a new motilide, ABT-229, on gastric emptying and postprandial antroduodenal motility in healthy volunteers
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of a motilin receptor agonist (ABT-229) on upper gastrointestinal symptoms in type 1 diabetes mellitus: a randomised, double blind, placebo controlled trial
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Failure of a motilin receptor agonist (ABT-229) to relieve the symptoms of functional dyspepsia in patients with and without delayed gastric emptying: a randomized double-blind placebo-controlled trial
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Efficacy of a motilin receptor agonist (ABT-229) for the treatment of gastro-oesophageal reflux disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
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New motilin agonists: a long and winding road
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Motilin
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
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Development of drugs for gastrointestinal motor disorders: translating science to clinical need
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7 January 2021
based on heuristic
inferred from DOI database lookup
Synthesis of 9-deoxo-4''-deoxy-6,9-epoxyerythromycin derivatives: novel and acid-stable motilides
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
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Preparation of 9-deoxo-4"-deoxy-6,9-epoxyerythromycin lactams "motilactides": potent and orally active prokinetic agents
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Synthesis and in vitro evaluation of [Leu13]porcine motilin fragments
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
D-amino acid and alanine scans of the bioactive portion of porcine motilin
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Structure-activity study of intact porcine motilin
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Exogenous motilin affects postprandial proximal gastric motor function and visceral sensation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of atilmotin on gastrointestinal transit in healthy subjects: a randomized, placebo-controlled study.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Design and synthesis of novel tetra-peptide motilin agonists
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacokinetic and pharmacodynamic studies of SK-896, a new human motilin analogue, in healthy male volunteers.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Discovery of a potent and novel motilin agonist
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of small molecule agonists of the motilin receptor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Desensitization of the human motilin receptor by motilides.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Differences in motilin receptor desensitization after stimulation with motilin or motilides are due to alternative receptor trafficking.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Promotility medications--now and in the future
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Domperidone. A review of its use in diabetic gastropathy
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
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5-HT4 receptor agonists enhance both cholinergic and nitrergic activities in human isolated colon circular muscle
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7 January 2021
based on heuristic
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Drug Insight: from disturbed motility to disordered movement--a review of the clinical benefits and medicolegal risks of metoclopramide
1 reference
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
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The use of erythromycin as a gastrointestinal prokinetic agent in adult critical care: benefits versus risks
1 reference
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
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Cisapride and erythromycin prokinetic effects in gastroparesis due to type 1 (insulin-dependent) diabetes mellitus
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7 January 2021
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Prokinetics in patients with gastroparesis: a systematic analysis
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
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Comparison of metoclopramide and erythromycin in the treatment of diabetic gastroparesis
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
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Gastric residual volume in children: a study comparing efficiency of erythromycin and metoclopramide as prokinetic agents
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
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Growth hormone secretagogue receptors in rat and human gastrointestinal tract and the effects of ghrelin
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
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Ghrelin stimulates motility in the small intestine of rats through intrinsic cholinergic neurons
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Ghrelin does not stimulate food intake in patients with surgical procedures involving vagotomy
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Anti-emetic activity of ghrelin in ferrets exposed to the cytotoxic anti-cancer agent cisplatin.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence that stimulation of ghrelin receptors in the spinal cord initiates propulsive activity in the colon of the rat
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Crossref
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Physiological, pathological and potential therapeutic roles of ghrelin.
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https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Actions and therapeutic pathways of ghrelin for gastrointestinal disorders
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Antagonistic properties of [Phe3,Leu13]porcine motilin
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reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
The motilin antagonist ANQ-11125 blocks motilide-induced contractions in vitro in the rabbit
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Erythromycin derivatives ABT 229 and GM 611 act on motilin receptors in the rabbit duodenum
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Contractile effects and intracellular Ca2+ signalling induced by motilin and erythromycin in the circular smooth muscle of human colon
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Design and synthesis of motilin antagonists derived from the [1-4] fragment of porcine motilin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anxiolytic effect of motilin and reversal with GM-109, a motilin antagonist, in mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Discovery of novel motilin antagonists: Conversion of tetrapeptide leads to orally available peptidomimetics
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oral administration of MA-2029, a novel selective and competitive motilin receptor antagonist, inhibits motilin-induced intestinal contractions and visceral pain in rabbits
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An orally active motilin receptor antagonist, MA-2029, inhibits motilin-induced gastrointestinal motility, increase in fundic tone, and diarrhea in conscious dogs without affecting gastric emptying.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of a nonpeptide motilin receptor antagonist on proximal gastric motor function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synthesis and SAR of 1,3-disubstituted cyclohexylmethyl urea and amide derivatives as non-peptidic motilin receptor antagonists
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Discovery of a new class of macrocyclic antagonists to the human motilin receptor.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Potent macrocyclic antagonists to the motilin receptor presenting novel unnatural amino acids.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High interdigestive and postprandial motilin levels in patients with the irritable bowel syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Colonic motility, autonomic function, and gastrointestinal hormones under psychological stress on irritable bowel syndrome.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An exaggerated sensory component of the gastrocolonic response in patients with irritable bowel syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vivo characterization of the colonic prokinetic effect of erythromycin in the rabbit
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitemcinal (GM-611), an orally active motilin agonist, facilitates defecation in rabbits and dogs without causing loose stools
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Motilin- and neuropeptide Y-like immunoreactivity in a psychophysiological stress experiment on patients with functional dyspepsia.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alterations of gut neuropeptides in gastroesophageal reflux disease are resolved after antireflux surgery
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The effects of ABT-229 and octreotide on interdigestive small bowel motility, bacterial overgrowth and bacterial translocation in rats.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6468%2809%2904802-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0079-6468(09)04802-4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21544957
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21544957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
PubMed publication ID
21544957
1 reference
stated in
Europe PubMed Central
PubMed publication ID
21544957
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21544957%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 January 2020
ResearchGate publication ID
51100593
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