(Q37873720)

24 August 2017

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title

Pathogenesis of antiphospholipid syndrome: understanding the antibodies (English)

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antiphospholipid syndrome

24 August 2017

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1

Pier Luigi Meroni

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24 August 2017

M Orietta Borghi

2

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24 August 2017

Elena Raschi

series ordinal

3

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24 August 2017

Francesco Tedesco

series ordinal

4

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24 August 2017

language of work or name

English

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publication date

10 May 2011

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Nature Reviews Rheumatology

24 August 2017

published in

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24 August 2017

volume

7

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24 August 2017

issue

6

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24 August 2017

page(s)

330-339

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https://scigraph.springernature.com/pub.10.1038/nrrheum.2011.52

24 August 2017

exact match

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cites work

International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Current concepts on the pathogenesis of the antiphospholipid syndrome

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Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanisms

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Mechanisms of disease: antiphospholipid antibodies-from clinical association to pathologic mechanism

21 January 2018

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Impaired fibrinolysis in the antiphospholipid syndrome

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Antiphospholipid syndrome and systemic lupus erythematosus: are they separate entities or just clinical presentations on the same scale?

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

The pathogenesis of neural injury in animal models of the antiphospholipid syndrome

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Thrombogenicity of beta 2-glycoprotein I-dependent antiphospholipid antibodies in a photochemically induced thrombosis model in the hamster

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Thrombus formation induced by antibodies to beta2-glycoprotein I is complement dependent and requires a priming factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

E-Selectin mediates pathogenic effects of antiphospholipid antibodies

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndrome

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Toll-like receptor and antiphospholipid mediated thrombosis: in vivo studies

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Antibodies to serine proteases in the antiphospholipid syndrome

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Anti-beta 2-glycoprotein I, antiprothrombin antibodies, and the risk of thrombosis in the antiphospholipid syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Clinical significance of different antiphospholipid antibodies in the WAPS (warfarin in the antiphospholipid syndrome) study

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Natural catalytic antibodies in norm, autoimmune, viral, and bacterial diseases.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Placental changes in a first trimester missed abortion in maternal systemic lupus erythematosus with antiphospholipid syndrome; a case report and review of the literature

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

The annexin A5-mediated pathogenic mechanism in the antiphospholipid syndrome: role in pregnancy losses and thrombosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

The Th1/Th2 paradigm: still important in pregnancy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Complement C3 activation is required for antiphospholipid antibody-induced fetal loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Antiphospholipid syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Excessive complement activation is associated with placental injury in patients with antiphospholipid antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Complement activation in anti-phospholipid syndrome: a clue for an inflammatory process?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Impaired expression of endometrial differentiation markers and complement regulatory proteins in patients with recurrent pregnancy loss associated with antiphospholipid syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Pathogenic role of anti-beta 2-glycoprotein I antibodies in antiphospholipid associated fetal loss: characterisation of beta 2-glycoprotein I binding to trophoblast cells and functional effects of anti-beta 2-glycoprotein I antibodies in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Neonatal effects of maternal antiphospholipid syndrome

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Antiendothelial cell antibodies in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

TLR2 is one of the endothelial receptors for beta 2-glycoprotein I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Annexin A2: biology and relevance to the antiphospholipid syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Effects of polyclonal IgG derived from patients with different clinical types of the antiphospholipid syndrome on monocyte signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Annexin A2 mediates anti-beta 2 GPI/beta 2 GPI-induced tissue factor expression on monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Platelet activation by dimeric beta2-glycoprotein I requires signaling via both glycoprotein Ibalpha and apolipoprotein E receptor 2'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Heparan sulfate proteoglycans in the basement membranes of the human placenta and decidua.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Toll-like receptors at the maternal-fetal interface in normal pregnancy and pregnancy disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Functional proteomics: examining the effects of hypoxia on the cytotrophoblast protein repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Glypican-1, Phosphacan/Receptor Protein-Tyrosine Phosphatase-ζ/β and its Ligand, Tenascin-C, are Expressed by Neural Stem Cells and Neural Cells Derived from Embryonic Stem Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Reelin and apolipoprotein E receptor 2 in the embryonic and mature brain: effects of an evolutionary change in the apoER2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Heparan sulfate proteoglycans function as receptors for fibroblast growth factor-2 activation of extracellular signal-regulated kinases 1 and 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Annexin A2 is involved in antiphospholipid antibody-mediated pathogenic effects in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Annexin A2 mediates endothelial cell activation by antiphospholipid/anti- 2 glycoprotein I antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Prevalence and clinical correlations of antibodies against six beta2-glycoprotein-I-related peptides in the antiphospholipid syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Domain I of beta2-glycoprotein I: its role as an epitope and the potential to be developed as a specific target for the treatment of the antiphospholipid syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

In vivo inhibition of antiphospholipid antibody-induced pathogenicity utilizing the antigenic target peptide domain I of beta2-glycoprotein I: proof of concept

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Infectious origin of the antiphospholipid syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Beta2-glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Phospholipid binding plasma proteins required for antiphospholipid antibody detection--an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

The cytolytically inactive terminal complement complex activates endothelial cells to express adhesion molecules and tissue factor procoagulant activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Role of tissue factor in the maternal immunological attack of the embryo in the antiphospholipid syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Thrombogenic properties of murine anti-cardiolipin antibodies induced by beta 2 glycoprotein 1 and human immunoglobulin G antiphospholipid antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Role of p38 mitogen-activated protein kinase in antiphospholipid antibody-mediated thrombosis and endothelial cell activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

An international multicentre-laboratory evaluation of a new assay to detect specifically lupus anticoagulants dependent on the presence of anti-beta2-glycoprotein autoantibodies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

A human monoclonal antiprothrombin antibody is thrombogenic in vivo and upregulates expression of tissue factor and E-selectin on endothelial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Association of autoantibodies against the phosphatidylserine-prothrombin complex with manifestations of the antiphospholipid syndrome and with the presence of lupus anticoagulant

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Antiprothrombin antibodies detected in two different assay systems. Prevalence and clinical significance in systemic lupus erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Pathogenesis of the antiphospholipid syndrome: an additional example of the mosaic of autoimmunity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Identification of anti-prothrombin antibodies in the anti-phospholipid syndrome that display the prothrombinase activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Beta 2 glycoprotein I is a substrate of thiol oxidoreductases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Anti-phospholipid antibody mediated fetal loss: still an open question from a pathogenic point of view

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

The effect of immunoglobulin G fractions from patients with lupus anticoagulant on placental prostacyclin and thromboxane production

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Reduction of annexin-V (placental anticoagulant protein-I) on placental villi of women with antiphospholipid antibodies and recurrent spontaneous abortion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

TNF-alpha is a critical effector and a target for therapy in antiphospholipid antibody-induced pregnancy loss

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

A novel inhibitor of the alternative complement pathway prevents antiphospholipid antibody-induced pregnancy loss in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Repeated fetal losses associated with antiphospholipid antibodies: a collaborative randomized trial comparing prednisone with low-dose heparin treatment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

A peptide that mimics the Vth region of beta-2-glycoprotein I reverses antiphospholipid-mediated thrombosis in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Cell surface proteoglycan expression during maturation of human monocytes-derived dendritic cells and macrophages

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Expression and function of syndecan-4 in human platelets

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Evidence of Toll-like receptor molecules on human platelets

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

The association between circulating antibodies against domain I of beta2-glycoprotein I and thrombosis: an international multicenter study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Complement activation in patients with primary antiphospholipid syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.52

Detection of complement-fixing antiphospholipid antibodies in association with thrombosis

31 March 2020

1 reference

12 December 2020

Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome

1 reference

12 December 2020

Beta 2 glycoprotein I and placental anticoagulant protein I in placentae from patients with antiphospholipid syndrome

1 reference

12 December 2020

The anti-beta2-glycoprotein I activity in human anti-phospholipid syndrome sera is due to monoreactive low-affinity autoantibodies directed to epitopes located on native beta2-glycoprotein I and preserved during species' evolution

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRRHEUM.2011.52

1 reference

Dimensions Publication ID

24 August 2017

1049967834

0 references

1 reference