(Q37883023)

24 August 2017

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title

Family-based designs for genome-wide association studies (English)

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genome-wide association study

24 August 2017

main subject

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3

Mark Lathrop

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24 August 2017

2

Yoichiro Kamatani

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24 August 2017

Jurg Ott

1

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24 August 2017

publication date

1 June 2011

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24 August 2017

published in

Nature Reviews Genetics

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24 August 2017

volume

12

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24 August 2017

issue

7

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24 August 2017

page(s)

465-474

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https://scigraph.springernature.com/pub.10.1038/nrg2989

24 August 2017

exact match

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Statistical analysis strategies for association studies involving rare variants

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The analysis of parental origin of alleles may detect susceptibility loci for complex disorders

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Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma

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Family-based methods for linkage and association analysis

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Efficient study designs for test of genetic association using sibship data and unrelated cases and controls

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A General Model for the Genetic Analysis of Pedigree Data

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The Elston-Stewart algorithm for continuous genotypes and environmental factors

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Ascertainment correction for Markov chain Monte Carlo segregation and linkage analysis of a quantitative trait.

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Linkage analysis and family classification under heterogeneity

31 March 2020

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HLODs remain powerful tools for detection of linkage in the presence of genetic heterogeneity

31 March 2020

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Homozygosity mapping reveals mutations of GRXCR1 as a cause of autosomal-recessive nonsyndromic hearing impairment

31 March 2020

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Parametric and nonparametric multipoint linkage analysis with imprinting and two-locus-trait models: application to mite sensitization

31 March 2020

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A novel approach to detect parent-of-origin effects from pedigree data with application to Beckwith-Wiedemann syndrome

31 March 2020

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The essence of linkage-based imprinting detection: comparing power, type 1 error, and the effects of confounders in two different analysis approaches

31 March 2020

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Variance components/major locus likelihood approximation for quantitative, polychotomous, and multivariate data

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Chromosome 6p22 locus associated with clinically aggressive neuroblastoma

31 March 2020

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Identification of ALK as a major familial neuroblastoma predisposition gene

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Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

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Comparison of four sib-pair linkage methods for analyzing sibships with more than two affecteds: interest of the binomial maximum likelihood approach.

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Direct power comparisons between simple LOD scores and NPL scores for linkage analysis in complex diseases

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Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children

31 March 2020

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CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs

31 March 2020

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Linkage of autosomal recessive primary congenital glaucoma to the GLC3A locus in Roms (Gypsies) from Slovakia

31 March 2020

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Ignoring linkage disequilibrium among tightly linked markers induces false-positive evidence of linkage for affected sib pair analysis

31 March 2020

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Merlin--rapid analysis of dense genetic maps using sparse gene flow trees

31 March 2020

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Programs for pedigree analysis: Mendel, Fisher, and dGene

31 March 2020

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Haplotyping methods for pedigrees

31 March 2020

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Linkage disequilibrium in humans: models and data

31 March 2020

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Genomic control for association studies

31 March 2020

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Principal components analysis corrects for stratification in genome-wide association studies

31 March 2020

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Haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculations

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Statistical properties of the haplotype relative risk

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A haplotype-based 'haplotype relative risk' approach to detecting allelic associations.

31 March 2020

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True pedigree errors more frequent than apparent errors for single nucleotide polymorphisms.

31 March 2020

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A transmission disequilibrium test for general pedigrees that is robust to the presence of random genotyping errors and any number of untyped parents.

31 March 2020

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Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease

31 March 2020

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Sometimes it's hot, sometimes it's not

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Association of genetic loci: replication or not, that is the question

31 March 2020

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Betting odds and genetic associations.

31 March 2020

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A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information.

31 March 2020

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Adaptation of the extended transmission/disequilibrium test to distinguish disease associations of multiple loci: the Conditional Extended Transmission/Disequilibrium Test

31 March 2020

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An entropy-based genome-wide transmission/disequilibrium test

31 March 2020

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Comments on the entropy-based transmission/disequilibrium test

31 March 2020

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Genetic association mapping based on discordant sib pairs: the discordant-alleles test

31 March 2020

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A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test

31 March 2020

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The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases I. DNA pooling

31 March 2020

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Use of parents, sibs, and unrelated controls for detection of associations between genetic markers and disease

31 March 2020

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MHC fine mapping of human type 1 diabetes using the T1DGC data

31 March 2020

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Genome-wide scan in 124 Indonesian sib-pair families with schizophrenia reveals genome-wide significant linkage to a locus on chromosome 3p26-21.

31 March 2020

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A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects

31 March 2020

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On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies

31 March 2020

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CD14and Toll-like Receptor Gene Polymorphisms, Country Living, and Asthma in Adults

31 March 2020

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A test for linkage and association in general pedigrees: the pedigree disequilibrium test

31 March 2020

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Analysis of maternal-offspring HLA compatibility, parent-of-origin and non-inherited maternal effects for the classical HLA loci in type 1 diabetes

31 March 2020

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Accounting for Linkage in Family-Based Tests of Association with Missing Parental Genotypes

31 March 2020

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Comparison of association mapping methods in a complex pedigreed population.

31 March 2020

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Strategies for multilocus linkage analysis in humans

31 March 2020

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An allele of COL9A2 associated with intervertebral disc disease

31 March 2020

1 reference

Joint modeling of linkage and association: identifying SNPs responsible for a linkage signal

31 March 2020

1 reference

Identification of a variant associated with adult-type hypolactasia

31 March 2020

1 reference

ROADTRIPS: case-control association testing with partially or completely unknown population and pedigree structure

31 March 2020

1 reference

A review of family-based tests for linkage disequilibrium between a quantitative trait and a genetic marker

31 March 2020

1 reference

Detection of putative functional angiotensinogen (AGT) gene variants controlling plasma AGT levels by combined segregation-linkage analysis

31 March 2020

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High-resolution genetic mapping of the ACE-linked QTL influencing circulating ACE activity

31 March 2020

1 reference

On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test

31 March 2020

1 reference

On the genome-wide analysis of copy number variants in family-based designs: methods for combining family-based and population-based information for testing dichotomous or quantitative traits, or completely ascertained samples

31 March 2020

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Balancing life-style and genomics research for disease prevention

31 March 2020

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Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study

31 March 2020

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Mapping of a susceptibility locus for Crohn's disease on chromosome 16

31 March 2020

1 reference

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

31 March 2020

1 reference

A statistical method for identification of polymorphisms that explain a linkage result

31 March 2020

1 reference

Evaluation of approaches to identify associated SNPs that explain the linkage evidence in nuclear families with affected siblings

31 March 2020

1 reference

Joint modeling of linkage and association using affected sib-pair data

31 March 2020

1 reference

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

31 March 2020

1 reference

Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4

31 March 2020

1 reference

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

31 March 2020

1 reference

Inflammatory bowel disease and mutations affecting the interleukin-10 receptor

31 March 2020

1 reference

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

31 March 2020

1 reference

Dissecting the loci controlling fetal haemoglobin production on chromosomes 11p and 6q by the regressive approach.

31 March 2020

1 reference

Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults

31 March 2020

1 reference

Control of fetal hemoglobin: new insights emerging from genomics and clinical implications

31 March 2020

1 reference

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

31 March 2020

1 reference

DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease

31 March 2020

1 reference

Developmental and species-divergent globin switching are driven by BCL11A

31 March 2020

1 reference

The TDT and other family-based tests for linkage disequilibrium and association

31 March 2020

1 reference

12 December 2020

Combined linkage and segregation analysis using regressive models

1 reference

12 December 2020

Detection of a major gene for heterocellular hereditary persistence of fetal hemoglobin after accounting for genetic modifiers.

1 reference

12 December 2020

Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics

1 reference

12 December 2020

The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases. II. Individual genotyping

1 reference

12 December 2020

A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease.

1 reference

12 December 2020

The haplotype-relative-risk (HRR) method for analysis of association in nuclear families.

1 reference

12 December 2020

Linkage studies in a large kindred with familial hypercholesterolemia

1 reference

12 December 2020

MCMC segregation and linkage analysis

1 reference

12 December 2020

Evidence for linkage of Charcot-Marie-Tooth neuropathy to the Duffy locus on chromosome 1.

1 reference

12 December 2020

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM)

1 reference

12 December 2020

Mapping disease genes: family-based association studies

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12 December 2020

Identifiers

DOI

10.1038/NRG2989

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24 August 2017

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