(Q37890251)

24 August 2017

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title

Microenvironmental regulation of stem cells in intestinal homeostasis and cancer (English)

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24 August 2017

2

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24 August 2017

Jan Paul Medema

1

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24 August 2017

language of work or name

English

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publication date

15 June 2011

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24 August 2017

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24 August 2017

volume

474

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24 August 2017

issue

7351

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24 August 2017

page(s)

318-326

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https://scigraph.springernature.com/pub.10.1038/nature10212

24 August 2017

exact match

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12 December 2020

Bmi1 is expressed in vivo in intestinal stem cells

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12 December 2020

Epithelial cell migration in the intestine

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12 December 2020

Wnt/beta-catenin signaling in cancer stemness and malignant behavior

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12 December 2020

Phenotypic characterization of human colorectal cancer stem cells

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12 December 2020

Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice

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12 December 2020

Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis

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12 December 2020

Polyclonal origin of colonic adenomas in an XO/XY patient with FAP.

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12 December 2020

Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells

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12 December 2020

Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.

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12 December 2020

The stem cells of small intestinal crypts: where are they?

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12 December 2020

Awakening dormant haematopoietic stem cells

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12 December 2020

Depletion of the colonic epithelial precursor cell compartment upon conditional activation of the hedgehog pathway.

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12 December 2020

Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients

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12 December 2020

Identification of stem cells in small intestine and colon by marker gene Lgr5

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12 December 2020

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

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12 December 2020

MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.

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12 December 2020

Immunity, Inflammation, and Cancer

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12 December 2020

DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency

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12 December 2020

Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.

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12 December 2020

Bone morphogenetic protein signaling is essential for terminal differentiation of the intestinal secretory cell lineage

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12 December 2020

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

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12 December 2020

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

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12 December 2020

Intestinal stem cell replacement follows a pattern of neutral drift

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12 December 2020

Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

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12 December 2020

LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis

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12 December 2020

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

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12 December 2020

Progenitor cells for the prostate epithelium: roles in development, regeneration, and cancer.

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12 December 2020

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

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12 December 2020

Hallmarks of Cancer: The Next Generation

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12 December 2020

APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression

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12 December 2020

Hedgehog: an unusual signal transducer

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12 December 2020

De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine

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12 December 2020

The genomic landscapes of human breast and colorectal cancers

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12 December 2020

Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors.

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12 December 2020

Dextran sodium sulfate strongly promotes colorectal carcinogenesis in Apc(Min/+) mice: inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms.

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12 December 2020

The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers

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12 December 2020

Loss of Indian Hedgehog activates multiple aspects of a wound healing response in the mouse intestine

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12 December 2020

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation

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12 December 2020

Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation

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12 December 2020

Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

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12 December 2020

Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation

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12 December 2020

IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

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12 December 2020

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

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12 December 2020

The epithelial-mesenchymal transition generates cells with properties of stem cells

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12 December 2020

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

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12 December 2020

Cells of origin in cancer

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12 December 2020

Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types

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12 December 2020

Biology of the adenomatous polyposis coli tumor suppressor

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12 December 2020

A genetic model for colorectal tumorigenesis

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12 December 2020

Expression pattern of Wnt signaling components in the adult intestine.

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12 December 2020

Molecular origins of cancer: Molecular basis of colorectal cancer

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12 December 2020

SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion

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12 December 2020

Mitogenic influence of human R-spondin1 on the intestinal epithelium

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12 December 2020

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

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12 December 2020

Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice

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12 December 2020

Notch signals control the fate of immature progenitor cells in the intestine

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12 December 2020

Crypt stem cells as the cells-of-origin of intestinal cancer

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12 December 2020

Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes

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12 December 2020

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

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12 December 2020

BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling

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12 December 2020

Targeting Wnt signaling in colon cancer stem cells

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12 December 2020

Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells

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12 December 2020

One renegade cancer stem cell?

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12 December 2020

Derivation of mouse intestinal crypts from single progenitor cells

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12 December 2020

Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells

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12 December 2020

Cancer stem cells--old concepts, new insights.

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12 December 2020

Colon cancer stem cells: promise of targeted therapy.

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12 December 2020

Organizing cell renewal in the intestine: stem cells, signals and combinatorial control

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12 December 2020

Cancer stem cell tumor model reveals invasive morphology and increased phenotypical heterogeneity.

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12 December 2020

Transcription factor achaete scute-like 2 controls intestinal stem cell fate

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12 December 2020

Post-irradiation somatic mutation and clonal stabilisation time in the human colon

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12 December 2020

Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene

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12 December 2020

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

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12 December 2020

Aberrant crypt foci: detection, gene abnormalities, and clinical usefulness

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12 December 2020

Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

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12 December 2020

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

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12 December 2020

Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity.

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12 December 2020

Identification and expansion of human colon-cancer-initiating cells

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12 December 2020

A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

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12 December 2020

Roles of myofibroblasts in prostaglandin E2-stimulated intestinal epithelial proliferation and angiogenesis

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12 December 2020

Wnt signalling in stem cells and cancer

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12 December 2020

The properties of a mammary gland cancer stem cell

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12 December 2020

The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.

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12 December 2020

Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas

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12 December 2020

Bone morphogenetic protein signalling in colorectal cancer.

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12 December 2020

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

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12 December 2020

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

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12 December 2020

Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice.

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12 December 2020

Aspirin use and survival after diagnosis of colorectal cancer

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12 December 2020

ERK activation drives intestinal tumorigenesis in Apc(min/+) mice

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12 December 2020

Mast cells are an essential hematopoietic component for polyp development

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12 December 2020

Somatic mutation, monoclonality and stochastic models of stem cell organization in the intestinal crypt

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12 December 2020

Mouse models of colon cancer

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12 December 2020

The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation

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12 December 2020

Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

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12 December 2020

Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling

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12 December 2020

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

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12 December 2020

Suppression of intestinal polyposis in Apc(delta 716) knockout mice by an additional mutation in the cytosolic phospholipase A(2) gene

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12 December 2020

Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.

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12 December 2020

Identifiers

DOI

10.1038/NATURE10212

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Dimensions Publication ID

24 August 2017

1017001013

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