(Q46244569)

20 December 2017

title

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation (English)

1 reference

20 December 2017

author

Andreas Trumpp

5

1 reference

20 December 2017

Owen J Sansom

6

1 reference

20 December 2017

Alan R. Clarke

7

1 reference

20 December 2017

Douglas J Winton

2

object named as

Douglas J Winton

1 reference

20 December 2017

Victoria Marsh Durban

1

object named as

Victoria Marsh

1 reference

20 December 2017

author name string

Geraint T Williams

3

1 reference

20 December 2017

Nicole Dubois

4

1 reference

20 December 2017

language of work or name

English

0 references

publication date

16 November 2008

1 reference

20 December 2017

published in

Nature Genetics

1 reference

20 December 2017

volume

40

1 reference

20 December 2017

issue

12

1 reference

20 December 2017

page(s)

1436-1444

1 reference

20 December 2017

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

cites work

1 reference

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

1 reference

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

1 reference

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

1 reference

Colorectal cancer: mutations in a signalling pathway

21 January 2018

1 reference

Genetic conditions associated with intestinal juvenile polyps

21 January 2018

1 reference

Pten is essential for embryonic development and tumour suppression

21 January 2018

1 reference

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

21 January 2018

1 reference

BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling

21 January 2018

1 reference

Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation

21 January 2018

1 reference

PTEN-deficient intestinal stem cells initiate intestinal polyposis

21 January 2018

1 reference

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

21 January 2018

1 reference

Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin

21 January 2018

1 reference

MBD2 deficiency does not accelerate p53 mediated lymphomagenesis

21 January 2018

1 reference

Generalized lacZ expression with the ROSA26 Cre reporter strain

21 January 2018

1 reference

Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]

21 January 2018

1 reference

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease

21 January 2018

1 reference

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

21 January 2018

1 reference

MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine

21 January 2018

1 reference

Tissue-specific and inducible Cre-mediated recombination in the gut epithelium

21 January 2018

1 reference

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

21 January 2018

1 reference

Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.

21 January 2018

1 reference

Elimination of background recombination: somatic induction of Cre by combined transcriptional regulation and hormone binding affinity.

21 January 2018

1 reference

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

21 January 2018

1 reference

Oncogenic transformation induced by membrane-targeted Akt2 and Akt3.

21 January 2018

1 reference

PTEN, a unique tumor suppressor gene

21 January 2018

1 reference

Differential, inducible gene targeting in renal epithelia, vascular endothelium, and viscera of Mx1Cre mice

21 January 2018

1 reference

LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis

21 January 2018

1 reference

Mucosal prolapse in the pathogenesis of Peutz-Jeghers polyposis.

21 January 2018

1 reference

The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice

21 January 2018

1 reference

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

21 January 2018

1 reference

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

21 January 2018

1 reference

Colorectal polyps in Cowden's disease (multiple hamartoma syndrome).

21 January 2018

1 reference

7 January 2021

Re-examination of P-PTEN staining patterns in the intestinal crypt

1 reference

7 January 2021

Apc deficiency predisposes to renal carcinoma in the mouse

1 reference

7 January 2021

Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas

1 reference

7 January 2021

Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation

1 reference

7 January 2021

Methods for the isolation of intact epithelium from the mouse intestine

1 reference

7 January 2021

Identifiers

DOI

10.1038/NG.256

1 reference

20 December 2017

1 reference

20 December 2017