(Q37893956)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21701502%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

review article

1 reference

title

Novel therapeutic targets for the treatment of heart failure (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21701502%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21701502%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

author name string

José López-Sendón

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21701502%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

language of work or name

1 reference

24 June 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21701502%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Drug Discovery

5 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21701502%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21701502%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21701502%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

page(s)

536-555

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21701502%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrd3431

5 February 2020

exact match

0 references

cites work

ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology

1 reference

Heart Disease and Stroke Statistics--2010 Update: A Report From the American Heart Association

21 January 2018

1 reference

Heart failure-related hospitalization in the U.S., 1979 to 2004.

21 January 2018

1 reference

Acute heart failure syndromes

21 January 2018

1 reference

Expert consensus document on angiotensin converting enzyme inhibitors in cardiovascular disease. The Task Force on ACE-inhibitors of the European Society of Cardiology

21 January 2018

1 reference

Expert consensus document on beta-adrenergic receptor blockers

21 January 2018

1 reference

Clinical trials of pharmacological therapies in acute heart failure syndromes: lessons learned and directions forward

21 January 2018

1 reference

New investigational drugs for the management of acute heart failure syndromes.

21 January 2018

1 reference

The future of pharmacological therapy for heart failure

21 January 2018

1 reference

Clinical development of pharmacologic agents for acute heart failure syndromes: a proposal for a mechanistic translational phase

21 January 2018

1 reference

End points for clinical trials in acute heart failure syndromes

21 January 2018

1 reference

Diastolic heart failure: mechanisms and controversies

21 January 2018

1 reference

Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment

21 January 2018

1 reference

Levosimendan vs dobutamine for patients with acute decompensated heart failure: the SURVIVE Randomized Trial

21 January 2018

1 reference

Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial

21 January 2018

1 reference

Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study

21 January 2018

1 reference

Loop diuretics in acute decompensated heart failure: necessary? Evil? A necessary evil?

21 January 2018

1 reference

Diuretics for the treatment of acute decompensated heart failure

21 January 2018

1 reference

Diuretic strategies in patients with acute decompensated heart failure

21 January 2018

1 reference

Impact of worsening renal function during hospital admission on resource utilization in patients with heart failure

21 January 2018

1 reference

Cardiorenal syndrome: new perspectives

21 January 2018

1 reference

Adenosine and kidney function: potential implications in patients with heart failure

21 January 2018

1 reference

Adenosine1 receptor antagonism: a new therapeutic approach for the treatment of decompensated heart failure

21 January 2018

1 reference

The PROTECT pilot study: a randomized, placebo-controlled, dose-finding study of the adenosine A1 receptor antagonist rolofylline in patients with acute heart failure and renal impairment

21 January 2018

1 reference

Rolofylline, an adenosine A1-receptor antagonist, in acute heart failure

21 January 2018

1 reference

Characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure: a report from the OPTIMIZE-HF Registry

21 January 2018

1 reference

Vasodilators in the treatment of acute heart failure: what we know, what we don't

21 January 2018

1 reference

Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions

21 January 2018

1 reference

Role of guanylate cyclase modulators in decompensated heart failure

21 January 2018

1 reference

Short-term risk of death after treatment with nesiritide for decompensated heart failure: a pooled analysis of randomized controlled trials

21 January 2018

1 reference

CD-NP: an innovative designer natriuretic peptide activator of particulate guanylyl cyclase receptors for cardiorenal disease

21 January 2018

1 reference

A novel chimeric natriuretic peptide reduces cardiomyocyte hypertrophy through the NHE-1-calcineurin pathway

21 January 2018

1 reference

Comparison of omapatrilat and enalapril in patients with chronic heart failure: the Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events (OVERTURE).

21 January 2018

1 reference

Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study

21 January 2018

1 reference

Urocortins in heart failure

21 January 2018

1 reference

Urocortin 2 infusion in human heart failure

21 January 2018

1 reference

Cinaciguat (BAY 58-2667) improves cardiopulmonary hemodynamics in patients with acute decompensated heart failure.

21 January 2018

1 reference

Relaxin: review of biology and potential role in treating heart failure

21 January 2018

1 reference

Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study.

21 January 2018

1 reference

Effects of long-term intravenous administration of adrenomedullin (AM) plus hANP therapy in acute decompensated heart failure: a pilot study

21 January 2018

1 reference

Eplerenone in patients with systolic heart failure and mild symptoms

21 January 2018

1 reference

Reconsidering the roles of the mineralocorticoid receptor

21 January 2018

1 reference

Aliskiren: the first renin inhibitor for clinical treatment

21 January 2018

1 reference

Signal transduction of the (pro)renin receptor as a novel therapeutic target for preventing end-organ damage

21 January 2018

1 reference

The comparative prognostic value of plasma neurohormones at baseline in patients with heart failure enrolled in Val-HeFT.

21 January 2018

1 reference

Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure

21 January 2018

1 reference

Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction

21 January 2018

1 reference

Compound 21, the first orally active, selective agonist of the angiotensin type 2 receptor (AT2): implications for AT2 receptor research and therapeutic potential

21 January 2018

1 reference

Pharmacokinetics and pharmacodynamics of mineralocorticoid blocking agents and their effects on potassium homeostasis

21 January 2018

1 reference

Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone

21 January 2018

1 reference

Aldosterone synthase inhibition with LCI699: a proof-of-concept study in patients with primary aldosteronism

21 January 2018

1 reference

Mechanisms and models in heart failure: the biomechanical model and beyond

21 January 2018

1 reference

Potential novel pharmacological therapies for myocardial remodelling

21 January 2018

1 reference

Cardiac fibroblasts: at the heart of myocardial remodeling

21 January 2018

1 reference

The cardiac fibroblast: therapeutic target in myocardial remodeling and failure

21 January 2018

1 reference

Matrix metalloproteinase therapy in heart failure

21 January 2018

1 reference

Effects of selective matrix metalloproteinase inhibitor (PG-116800) to prevent ventricular remodeling after myocardial infarction: results of the PREMIER (Prevention of Myocardial Infarction Early Remodeling) trial.

21 January 2018

1 reference

Role of proteases in the pathophysiology of cardiac disease

21 January 2018

1 reference

The immune system and chronic heart failure: is the heart in control?

21 January 2018

1 reference

Inhibition of interleukin-1 by anakinra improves vascular and left ventricular function in patients with rheumatoid arthritis

21 January 2018

1 reference

Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot study).

21 January 2018

1 reference

Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics

21 January 2018

1 reference

Regulation of cardiac remodeling by nitric oxide: focus on cardiac myocyte hypertrophy and apoptosis

21 January 2018

1 reference

Acute phosphodiesterase 5 inhibition mimics hemodynamic effects of B-type natriuretic peptide and potentiates B-type natriuretic peptide effects in failing but not normal canine heart.

21 January 2018

1 reference

Clinical use of phosphodiesterase-5 inhibitors in chronic heart failure

21 January 2018

1 reference

PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: results of a 1-year, prospective, randomized, placebo-controlled study.

21 January 2018

1 reference

Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction

21 January 2018

1 reference

Impact of oxypurinol in patients with symptomatic heart failure. Results of the OPT-CHF study

21 January 2018

1 reference

Protein kinase C in heart failure: a therapeutic target?

21 January 2018

1 reference

Control of cardiac growth by histone acetylation/deacetylation

21 January 2018

1 reference

Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure

21 January 2018

1 reference

Inhibition of elevated Ca2+/calmodulin-dependent protein kinase II improves contractility in human failing myocardium

21 January 2018

1 reference

Effects of alagebrium, an advanced glycation end-product breaker, in patients with chronic heart failure: study design and baseline characteristics of the BENEFICIAL trial

21 January 2018

1 reference

Intracellular calcium release and cardiac disease

21 January 2018

1 reference

Toward biologically targeted therapy of calcium cycling defects in heart failure

21 January 2018

1 reference

Enhanced ryanodine receptor-mediated calcium leak determines reduced sarcoplasmic reticulum calcium content in chronic canine heart failure

21 January 2018

1 reference

Ca2+ cycling and new therapeutic approaches for heart failure

21 January 2018

1 reference

Ryanodine receptor-mediated arrhythmias and sudden cardiac death.

21 January 2018

1 reference

Cardiac-targeted delivery of regulatory RNA molecules and genes for the treatment of heart failure

21 January 2018

1 reference

Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure

21 January 2018

1 reference

Correction of defective interdomain interaction within ryanodine receptor by antioxidant is a new therapeutic strategy against heart failure

21 January 2018

1 reference

Ryanodine receptor calcium channels and their partners as drug targets.

21 January 2018

1 reference

K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum

21 January 2018

1 reference

Chronic heart rate reduction with ivabradine improves systolic function of the reperfused heart through a dual mechanism involving a direct mechanical effect and a long-term increase in FKBP12/12.6 expression.

21 January 2018

1 reference

Role of neuregulin-1/ErbB2 signaling in endothelium-cardiomyocyte cross-talk.

21 January 2018

1 reference

Metabolic mechanisms in heart failure

21 January 2018

1 reference

Myocardial fatty acid metabolism in health and disease

21 January 2018

1 reference

Targeting malonyl CoA inhibition of mitochondrial fatty acid uptake as an approach to treat cardiac ischemia/reperfusion

21 January 2018

1 reference

New drugs for the treatment of diabetes: part II: Incretin-based therapy and beyond

21 January 2018

1 reference

Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways

21 January 2018

1 reference

DPP-4 inhibition by sitagliptin improves the myocardial response to dobutamine stress and mitigates stunning in a pilot study of patients with coronary artery disease

21 January 2018

1 reference

Insulin-resistant cardiomyopathy clinical evidence, mechanisms, and treatment options

21 January 2018

1 reference

Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic review

21 January 2018

1 reference

Treatment of type 2 diabetes and outcomes in patients with heart failure: a nested case-control study from the U.K. General Practice Research Database

21 January 2018

1 reference

AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B.

21 January 2018

1 reference

Heart failure as a multiple hormonal deficiency syndrome

21 January 2018

1 reference

Acute effects of triiodothyronine (T3) replacement therapy in patients with chronic heart failure and low-T3 syndrome: a randomized, placebo-controlled study

21 January 2018

1 reference

Micronutrient deficiencies an unmet need in heart failure

21 January 2018

1 reference

Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial

21 January 2018

1 reference

Omega-3 polyunsaturated fatty acids and cardiovascular diseases

21 January 2018

1 reference

Predictors of mortality and morbidity in patients with chronic heart failure

21 January 2018

1 reference

Modulation of cardiac contraction, relaxation and rate by the endothelial nitric oxide synthase (eNOS): lessons from genetically modified mice.

21 January 2018

1 reference

Effect of the long-term administration of nebivolol on clinical symptoms, exercise capacity and left ventricular function in patients with heart failure and preserved left ventricular ejection fraction: background, aims and design of the ELANDD stud

21 January 2018

1 reference

Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction

21 January 2018

1 reference

Antiatherosclerotic effects of small-molecular-weight compounds enhancing endothelial nitric-oxide synthase (eNOS) expression and preventing eNOS uncoupling

21 January 2018

1 reference

Heart failure with preserved ejection fraction is characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency.

21 January 2018

1 reference

Pathophysiology and pharmacology of the cardiac "late sodium current.".

21 January 2018

1 reference

Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure

21 January 2018

1 reference

Arginine vasopressin antagonists for the treatment of heart failure and hyponatremia

21 January 2018

1 reference

Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: the EVEREST Clinical Status Trials

21 January 2018

1 reference

Effects of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST Outcome Trial

21 January 2018

1 reference

Anemia and chronic heart failure implications and treatment options.

21 January 2018

1 reference

Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial

21 January 2018

1 reference

Ferric carboxymaltose in patients with heart failure and iron deficiency

21 January 2018

1 reference

The potential role of erythropoietin in chronic heart failure: from the correction of anemia to improved perfusion and reduced apoptosis?

21 January 2018

1 reference

A meta-analysis of erythropoiesis-stimulating agents in anaemic patients with chronic heart failure

21 January 2018

1 reference

Erythropoietin treatment in patients with chronic heart failure: a meta-analysis.

21 January 2018

1 reference

Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia

21 January 2018

1 reference

Design of the Reduction of Events with Darbepoetin alfa in Heart Failure (RED-HF): a Phase III, anaemia correction, morbidity-mortality trial.

21 January 2018

1 reference

Investigational positive inotropic agents for acute heart failure.

21 January 2018

1 reference

Agents with inotropic properties for the management of acute heart failure syndromes. Traditional agents and beyond

21 January 2018

1 reference

Role of inotropic agents in the treatment of heart failure.

21 January 2018

1 reference

Evidence-based use of levosimendan in different clinical settings

21 January 2018

1 reference

Clinical trials update from the American Heart Association: REPAIR-AMI, ASTAMI, JELIS, MEGA, REVIVE-II, SURVIVE, and PROACTIVE.

21 January 2018

1 reference

Hemodynamic, echocardiographic, and neurohormonal effects of istaroxime, a novel intravenous inotropic and lusitropic agent: a randomized controlled trial in patients hospitalized with heart failure

21 January 2018

1 reference

Effects of istaroxime on diastolic stiffness in acute heart failure syndromes: results from the Hemodynamic, Echocardiographic, and Neurohormonal Effects of Istaroxime, a Novel Intravenous Inotropic and Lusitropic Agent: a Randomized Controlled Tria

21 January 2018

1 reference

A novel approach to improve cardiac performance: cardiac myosin activators

21 January 2018

1 reference

Vascular effects of apelin in vivo in man.

21 January 2018

1 reference

Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure.

21 January 2018

1 reference

2009 Focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Deve

21 January 2018

1 reference

A global rank end point for clinical trials in acute heart failure

31 March 2020

1 reference

Clinical trials update from the European Society of Cardiology Heart Failure Meeting 2010: TRIDENT 1, BENEFICIAL, CUPID, RFA-HF, MUSIC, DUEL, handheld BNP, phrenic nerve stimulation, CHAMPION and CABG with CRT study

31 March 2020

1 reference

Toll-Like Receptor 4 Mediates Maladaptive Left Ventricular Remodeling and Impairs Cardiac Function After Myocardial Infarction

31 March 2020

1 reference

Tranilast attenuates diastolic dysfunction and structural injury in experimental diabetic cardiomyopathy

31 March 2020

1 reference

Chronic allopurinol administration ameliorates maladaptive alterations in Ca2+ cycling proteins and beta-adrenergic hyporesponsiveness in heart failure

31 March 2020

1 reference

Calmodulin kinase II inhibition protects against structural heart disease

31 March 2020

1 reference

A Phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure

31 March 2020

1 reference

Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure

31 March 2020

1 reference

Metformin but not glyburide prevents high glucose-induced abnormalities in relaxation and intracellular Ca2+ transients in adult rat ventricular myocytes

31 March 2020

1 reference

Erythropoiesis-stimulating agents for anaemia in chronic heart failure patients

31 March 2020

1 reference

Correction of anemia with epoetin alfa in chronic kidney disease

31 March 2020

1 reference

Omecamtiv mecarbil cardiac myosin activator treatment of heart failure

31 March 2020

1 reference

Aldosterone synthase inhibitors: pharmacological and clinical aspects

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21701502

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cinaciguat, a soluble guanylate cyclase activator for the potential treatment of acute heart failure

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21701502

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRD3431

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21701502%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference