(Q37898749)

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Reducing cardiovascular disease risk in patients with type 2 diabetes and concomitant macrovascular disease: can insulin be too much of a good thing?

scientific article published on December 2011

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scholarly article

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Europe PubMed Central

25 August 2017

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Europe PubMed Central

Reducing cardiovascular disease risk in patients with type 2 diabetes and concomitant macrovascular disease: can insulin be too much of a good thing? (English)

1 reference

Europe PubMed Central

25 August 2017

type 2 diabetes

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cardiovascular disease

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based on heuristic

inferred from title

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based on heuristic

inferred from title

John J. P. Kastelein

6

object named as

J J P Kastelein

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Europe PubMed Central

25 August 2017

author name string

K L Rensing

1

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Europe PubMed Central

25 August 2017

A Q Reuwer

2

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Europe PubMed Central

25 August 2017

B J Arsenault

3

1 reference

Europe PubMed Central

25 August 2017

J H von der Thüsen

4

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Europe PubMed Central

25 August 2017

J B L Hoekstra

5

1 reference

Europe PubMed Central

25 August 2017

Th B Twickler

7

1 reference

Europe PubMed Central

25 August 2017

language of work or name

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based on heuristic

inferred from title

publication date

1 December 2011

1 reference

Europe PubMed Central

25 August 2017

Diabetes, Obesity and Metabolism

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Europe PubMed Central

25 August 2017

13

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Europe PubMed Central

25 August 2017

12

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Europe PubMed Central

25 August 2017

1073-1087

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Europe PubMed Central

25 August 2017

Global estimates of the prevalence of diabetes for 2010 and 2030

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

The effect of glycemic control on the incidence of macrovascular complications of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Effects of intensive glucose lowering in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Glucose control and vascular complications in veterans with type 2 diabetes

1 reference

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21 January 2018

High blood glucose concentration is a risk factor for mortality in middle-aged nondiabetic men. 20-year follow-up in the Whitehall Study, the Paris Prospective Study, and the Helsinki Policemen Study

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

10-year follow-up of intensive glucose control in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Epidemiologic relationships between A1C and all-cause mortality during a median 3.4-year follow-up of glycemic treatment in the ACCORD trial

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Intensive glucose control and macrovascular outcomes in type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Intensive glucose-lowering therapy reduces cardiovascular disease events in veterans affairs diabetes trial participants with lower calcified coronary atherosclerosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

The relationship of abnormal circulating insulin levels to atherosclerosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Insulin treatment and cardiovascular disease; friend or foe? A point of view.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Effects of chronic hyperinsulinemia in insulin-resistant patients

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Insulin and endothelial function: physiological environment defines effect on atherosclerotic risk

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Insulin Is an Anti-inflammatory and Anti-atherosclerotic Hormone.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Insulin as an anti-inflammatory and antiatherogenic modulator

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Anti-inflammatory and profibrinolytic effect of insulin in acute ST-segment-elevation myocardial infarction

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

C-reactive protein levels following acute myocardial infarction: effect of insulin infusion and tight glycemic control

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

The Hyperglycemia: Intensive Insulin Infusion in Infarction (HI-5) study: a randomized controlled trial of insulin infusion therapy for myocardial infarction.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Tight glycemic control reduces heart inflammation and remodeling during acute myocardial infarction in hyperglycemic patients.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Continuous perioperative insulin infusion decreases major cardiovascular events in patients undergoing vascular surgery: a prospective, randomized trial.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Glucose, insulin and potassium applied as perioperative hyperinsulinaemic normoglycaemic clamp: effects on inflammatory response during coronary artery surgery

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

The impact of glucose lowering treatment on long-term prognosis in patients with type 2 diabetes and myocardial infarction: a report from the DIGAMI 2 trial.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Glucose lowering treatment in patients with coronary artery disease is prognostically important not only in established but also in newly detected diabetes mellitus: a report from the Euro Heart Survey on Diabetes and the Heart

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Association between serious ischemic cardiac outcomes and medications used to treat diabetes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Survival as a function of HbA(1c) in people with type 2 diabetes: a retrospective cohort study

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

A1C and cardiovascular outcomes in type 2 diabetes: a nested case-control study

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Insulin use and increased risk of mortality in type 2 diabetes: a cohort study.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Relationship of Glucose Tolerance and Plasma Insulin to the Incidence of Coronary Heart Disease: Results from Two Population Studies in Finland

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Relationship of plasma insulin levels to the incidence of myocardial infarction and coronary heart disease mortality in a middle-aged population.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Hyperinsulinemia as an independent risk factor for ischemic heart disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Circulating concentrations of insulin markers and coronary heart disease: a quantitative review of 19 Western prospective studies

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

The role of nitric oxide in cardiovascular diseases

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Protein kinase C theta activation induces insulin-mediated constriction of muscle resistance arteries

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Oral insulin supplementation attenuates atherosclerosis progression in apolipoprotein E-deficient mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Insulin increases reendothelialization and inhibits cell migration and neointimal growth after arterial injury

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Inflammation and atherosclerosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Insulin potentiates cytokine-induced VCAM-1 expression in human endothelial cells.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Insulin and insulin-like growth factor-I receptors differentially mediate insulin-stimulated adhesion molecule production by endothelial cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Insulin facilitates monocyte migration: a possible link to tissue inflammation in insulin-resistance

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

High insulin exacerbates neutrophil-endothelial cell adhesion through endothelial surface expression of intercellular adhesion molecule-1 via activation of protein kinase C and mitogen-activated protein kinase.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Influence of insulin on cholesterol removal from macrophages and cholesterol ester uptake by HepG2 cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Insulin up-regulates tumor necrosis factor-alpha production in macrophages through an extracellular-regulated kinase-dependent pathway

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Insulin augments matrix metalloproteinase-9 expression in monocytes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Role of smooth muscle cells in the initiation and early progression of atherosclerosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Effect of insulin on growth of cultured human arterial smooth muscle cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Transforming growth factor beta 1 inhibits the proliferative effect of insulin on human infragenicular vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Effect of insulin on the proliferation of cultured primate arterial smooth muscle cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Insulin-mediated regulation of the endothelial renin-angiotensin system and vascular cell growth

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Potentiation of mitogenic activity of platelet-derived growth factor by physiological concentrations of insulin via the MAP kinase cascade in rat A10 vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

PDGF and cardiovascular disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Insulin inhibits migration of vascular smooth muscle cells with inducible nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Atherosclerosis — An Inflammatory Disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Dependence of augmentation of arterial endothelial cell expression of plasminogen activator inhibitor type 1 by insulin on soluble factors released from vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Augmentation of arterial endothelial cell expression of the plasminogen activator inhibitor type-1 (PAI-1) gene by proinsulin and insulin in vivo

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Insulin-treated diabetes is associated with a marked increase in mortality in patients with advanced heart failure

1 reference

https://api.crossref.org/works/10.1111%2FJ.1463-1326.2011.01468.X

21 January 2018

Identifiers

10.1111/J.1463-1326.2011.01468.X

1 reference

Europe PubMed Central

25 August 2017

1 reference

Europe PubMed Central

25 August 2017

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