(Q37899782)

25 August 2017

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title

The kynurenine system and immunoregulation (English)

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25 August 2017

2

László Vécsei

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25 August 2017

Yvette Mándi

1

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25 August 2017

publication date

9 July 2011

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Journal of Neural Transmission

25 August 2017

published in

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25 August 2017

volume

119

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25 August 2017

issue

2

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25 August 2017

page(s)

197-209

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https://scigraph.springernature.com/pub.10.1007/s00702-011-0681-y

25 August 2017

exact match

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cites work

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Association of interferon-gamma +874(T/A) single nucleotide polymorphism with the rate of tryptophan catabolism in healthy individuals

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The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications

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Tryptophan and the immune response

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TGF-beta and kynurenines as the key to infectious tolerance

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l-Kynurenine Its synthesis and possible regulatory function in brain

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Tryptophan kynurenine metabolism as a common mediator of genetic and environmental impacts in major depressive disorder: the serotonin hypothesis revisited 40 years later

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High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes

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Elevated circulating tumor necrosis factor levels in Alzheimer's disease

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Kynurenines in chronic neurodegenerative disorders: future therapeutic strategies

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12 December 2020

Severe tryptophan starvation blocks onset of conventional persistence and reduces reactivation of Chlamydia trachomatis

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12 December 2020

IDO expands human CD4+CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cells

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12 December 2020

Allele frequencies of +874T-->A single nucleotide polymorphism at the first intron of interferon-gamma gene in a group of Italian centenarians

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12 December 2020

Tumor necrosis factor-alpha production by astrocytes. Induction by lipopolysaccharide, IFN-gamma, and IL-1 beta

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12 December 2020

IDO expression by dendritic cells: tolerance and tryptophan catabolism

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12 December 2020

Decreased T cellular immune response in schizophrenic patients.

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12 December 2020

IFN-gamma activated indoleamine 2,3-dioxygenase activity in human cells is an antiparasitic and an antibacterial effector mechanism

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12 December 2020

Transforming growth factor-beta regulation of immune responses

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12 December 2020

Kynurenic acid blocks nicotinic synaptic transmission to hippocampal interneurons in young rats

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12 December 2020

Mini-review: The nuclear protein HMGB1 as a proinflammatory mediator

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12 December 2020

Innovative uses of tumor necrosis factor alpha inhibitors

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12 December 2020

High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease

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12 December 2020

Regulatory role of tryptophan degradation pathway in HLA-G expression by human monocyte-derived dendritic cells

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12 December 2020

Kynurenine metabolism in multiple sclerosis.

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12 December 2020

The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells

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12 December 2020

Endogenous kynurenines as targets for drug discovery and development

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12 December 2020

TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NF kappa B inhibition

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12 December 2020

Toward an understanding of NKT cell biology: progress and paradoxes

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12 December 2020

Prevention of allogeneic fetal rejection by tryptophan catabolism

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12 December 2020

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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12 December 2020

Comparative behavioral and neurochemical studies with striatal kainic acid- or quinolinic acid-lesioned rats.

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12 December 2020

Kynurenines in the CNS: from endogenous obscurity to therapeutic importance

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12 December 2020

Indoleamine 2,3-dioxygenase expression in monocytes of healthy nonpregnant women after induction with human choriongonadotropine

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12 December 2020

Expression of functional GPR35 in human iNKT cells

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12 December 2020

Indoleamine 2,3-dioxygenase: distribution and function in the developing human placenta

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12 December 2020

High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal

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12 December 2020

Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain.

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12 December 2020

Immune System and Schizophrenia

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12 December 2020

Systemic inflammation and remote organ injury following trauma require HMGB1

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12 December 2020

Kynurenic acid inhibits intestinal hypermotility and xanthine oxidase activity during experimental colon obstruction in dogs

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12 December 2020

IFN-gamma-induced IDO and WRS expression in microglia is differentially regulated by IL-4.

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12 December 2020

The role of high mobility group box-1 protein in severe sepsis

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12 December 2020

The role of indoleamine 2,3-dioxygenase (IDO) in the pathophysiology of interferon-alpha-induced depression

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12 December 2020

Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain

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12 December 2020

Immunosuppression routed via the kynurenine pathway: a biochemical and pathophysiologic approach.

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12 December 2020

Interleukin-4 inhibits indoleamine 2,3-dioxygenase expression in human monocytes

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Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level

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12 December 2020

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12 December 2020

Plasma concentrations of high-mobility group box protein 1, soluble receptor for advanced glycation end-products and circulating DNA in patients with acute pancreatitis

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12 December 2020

Neurotoxic and neuroprotective metabolites of kynurenine in patients with renal cell carcinoma treated with interferon-alpha: course and relationship with psychiatric status

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12 December 2020

Transcriptional activation of indoleamine dioxygenase by interleukin 1 and tumor necrosis factor alpha in interferon-treated epithelial cells

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12 December 2020

Effects of systemic and central nervous system localized inflammation on the contributions of metabolic precursors to the L-kynurenine and quinolinic acid pools in brain

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12 December 2020

Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolysis

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12 December 2020

Altered tryptophan and neopterin metabolism in cancer patients treated with recombinant interleukin 2

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12 December 2020

IDO: a double-edged sword for T(H)1/T(H)2 regulation

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12 December 2020

Immunosuppression via tryptophan catabolism: the role of kynurenine pathway enzymes

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12 December 2020

Schizophrenia as an inflammation-mediated dysbalance of glutamatergic neurotransmission

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12 December 2020

Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin

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12 December 2020

Blood levels of kynurenines, interleukin-23 and soluble human leucocyte antigen-G at different stages of Huntington's disease

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12 December 2020

Invariant natural killer T cells: innate-like T cells with potent immunomodulatory activities

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12 December 2020

Decreased tryptophan catabolism by placental indoleamine 2,3-dioxygenase in preeclampsia

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12 December 2020

Alterations in kynurenine precursor and product levels in schizophrenia and bipolar disorder

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12 December 2020

The role of cytokines in immunological tolerance: potential for therapy

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12 December 2020

IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-kappaB activation

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12 December 2020

CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression

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12 December 2020

T cell apoptosis by tryptophan catabolism

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12 December 2020

Cytokine–serotonin interaction through IDO: a neurodegeneration hypothesis of depression

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12 December 2020

Genetic and hormonal regulation of tryptophan kynurenine metabolism: implications for vascular cognitive impairment, major depressive disorder, and aging.

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12 December 2020

The immunological basis of glutamatergic disturbance in schizophrenia: towards an integrated view.

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12 December 2020

Kynurenines in neurodegenerative disorders: therapeutic consideration.

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12 December 2020

Neuropharmacology of quinolinic and kynurenic acids

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12 December 2020

L-kynurenine-induced apoptosis in human NK cells is mediated by reactive oxygen species

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12 December 2020

Role of transforming growth factor beta in human disease

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12 December 2020

Tolerance, DCs and tryptophan: much ado about IDO

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12 December 2020

Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS

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12 December 2020

Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35

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12 December 2020

IL-4 and IL-13 regulate the induction of indoleamine 2,3-dioxygenase activity and the control of Toxoplasma gondii replication in human fibroblasts activated with IFN-gamma

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12 December 2020

A crucial role for tryptophan catabolism at the host/Candida albicans interface.

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12 December 2020

Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase.

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12 December 2020

Role of kynurenines in the central and peripheral nervous systems

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12 December 2020

Mammalian defensins in immunity: more than just microbicidal

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12 December 2020

A link between stress and depression: shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression

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12 December 2020

Kynurenine pathway in schizophrenia: pathophysiological and therapeutic aspects

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12 December 2020

Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human islets

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12 December 2020

Biology of natural killer cells

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12 December 2020

Human neutrophil peptides: a novel potential mediator of inflammatory cardiovascular diseases

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12 December 2020

Modulation of invariant natural killer T cell cytokine responses by indoleamine 2,3-dioxygenase

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12 December 2020

Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection

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12 December 2020

Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities

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12 December 2020

Profiling dendritic cell maturation with dedicated microarrays

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12 December 2020

Kynurenine pathway in psychosis: evidence of increased tryptophan degradation.

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12 December 2020

Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders

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12 December 2020

Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection

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12 December 2020

Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites

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12 December 2020

Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders

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12 December 2020

Cutting edge: Autocrine TGF-beta sustains default tolerogenesis by IDO-competent dendritic cells.

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12 December 2020

The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression - and other conditions characterized by tryptophan depletion induced by inflammation

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12 December 2020

Linking two immuno-suppressive molecules: indoleamine 2,3 dioxygenase can modify HLA-G cell-surface expression.

1 reference

12 December 2020

Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons

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12 December 2020

NK cells and cancer immunosurveillance.

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12 December 2020

Increased plasma kynurenine values and kynurenine-tryptophan ratios after major trauma are early indicators for the development of sepsis

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12 December 2020

Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific

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12 December 2020

Cerebral synthesis and release of kynurenic acid: an endogenous antagonist of excitatory amino acid receptors.

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12 December 2020

Understanding the behavior of invariant NKT cells in autoimmune diseases

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12 December 2020

Cooperative role of interferon regulatory factor 1 and p91 (STAT1) response elements in interferon-gamma-inducible expression of human indoleamine 2,3-dioxygenase gene

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12 December 2020

Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7

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12 December 2020

Neuroprotective effect of L-kynurenine sulfate administered before focal cerebral ischemia in mice and global cerebral ischemia in gerbils

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12 December 2020

Different inhibitory effects of kynurenic acid and a novel kynurenic acid analogue on tumour necrosis factor-α (TNF-α) production by mononuclear cells, HMGB1 production by monocytes and HNP1-3 secretion by neutrophils

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12 December 2020

Differential regulation of human indoleamine 2,3-dioxygenase gene expression by interferons-gamma and -alpha. Analysis of the regulatory region of the gene and identification of an interferon-gamma-inducible DNA-binding factor

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12 December 2020

The role of IFN-gamma and TNF-alpha-responsive regulatory elements in the synergistic induction of indoleamine dioxygenase

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12 December 2020

Depression induced by treatment with interferon-alpha in patients affected by hepatitis C virus

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12 December 2020

The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function

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12 December 2020

Quinolinic acid production by macrophages stimulated with IFN-gamma, TNF-alpha, and IFN-alpha.

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12 December 2020

A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-gamma production

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12 December 2020

TNF-mediated inflammatory disease.

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12 December 2020

HLA-G molecules: from maternal-fetal tolerance to tissue acceptance

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12 December 2020

Interferon-gamma-induced conversion of tryptophan: immunologic and neuropsychiatric aspects

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12 December 2020

TGFbeta signalling in control of T-cell-mediated self-reactivity

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12 December 2020

10.1007/S00702-011-0681-Y

Identifiers

DOI

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25 August 2017

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