(Q37900486)

25 August 2017

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title

Phosphatases: providing safe passage through mitotic exit (English)

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25 August 2017

Claudia Wurzenberger

1

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PubMed ID

21750572

25 August 2017

Daniel W Gerlich

series ordinal

2

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25 August 2017

13 July 2011

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Nature Reviews Molecular Cell Biology

25 August 2017

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25 August 2017

12

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25 August 2017

469-482

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25 August 2017

8

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https://scigraph.springernature.com/pub.10.1038/nrm3149

25 August 2017

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cites work

Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding

1 reference

Orchestrating nuclear envelope disassembly and reassembly during mitosis

21 January 2018

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Mitotic chromosome structure and condensation

21 January 2018

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Cisternal organization of the endoplasmic reticulum during mitosis

21 January 2018

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Golgi membranes are absorbed into and reemerge from the ER during mitosis

21 January 2018

1 reference

A quantitative atlas of mitotic phosphorylation

21 January 2018

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Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution

21 January 2018

1 reference

Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages

21 January 2018

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Phosphoproteome analysis of the human mitotic spindle

21 January 2018

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Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis

21 January 2018

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The Plk1-dependent phosphoproteome of the early mitotic spindle

21 January 2018

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The anaphase promoting complex/cyclosome: a machine designed to destroy

21 January 2018

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Cubism and the cell cycle: the many faces of the APC/C.

21 January 2018

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The spindle-assembly checkpoint in space and time

21 January 2018

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Finishing mitosis, one step at a time.

21 January 2018

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Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells

21 January 2018

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Mitosis: a matter of getting rid of the right protein at the right time

21 January 2018

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The processivity of multiubiquitination by the APC determines the order of substrate degradation.

21 January 2018

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Destruction box-dependent degradation of aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1.

21 January 2018

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APC/C Cdh1 targets aurora kinase to control reorganization of the mitotic spindle at anaphase.

21 January 2018

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Mitotic phosphatases: from entry guards to exit guides

21 January 2018

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Protein phosphatases take the mitotic stage.

21 January 2018

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Cdk-counteracting phosphatases unlock mitotic exit

21 January 2018

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Mitotic phosphatases: no longer silent partners

21 January 2018

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In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase

21 January 2018

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Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis

21 January 2018

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Phosphorylation of Nup98 by multiple kinases is crucial for NPC disassembly during mitotic entry

21 January 2018

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Recruitment of protein phosphatase 1 to the nuclear envelope by A-kinase anchoring protein AKAP149 is a prerequisite for nuclear lamina assembly

21 January 2018

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Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells

21 January 2018

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PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner

21 January 2018

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Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis

21 January 2018

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Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability

21 January 2018

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PP1/Repo-man dephosphorylates mitotic histone H3 at T3 and regulates chromosomal aurora B targeting

21 January 2018

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Mitotic division of the mammalian Golgi apparatus

21 January 2018

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The mitotic phosphorylation cycle of the cis-Golgi matrix protein GM130

21 January 2018

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Cell cycle regulation of central spindle assembly.

21 January 2018

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Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1

21 January 2018

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Spatiotemporal control of spindle midzone formation by PRC1 in human cells

21 January 2018

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Cdk1 negatively regulates midzone localization of the mitotic kinesin Mklp2 and the chromosomal passenger complex

21 January 2018

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Separase Regulates INCENP-Aurora B Anaphase Spindle Function Through Cdc14

21 January 2018

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Sli15(INCENP) dephosphorylation prevents mitotic checkpoint reengagement due to loss of tension at anaphase onset

21 January 2018

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Inhibition of cdc2 activation by INH/PP2A.

21 January 2018

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Dephosphorylation of cdc25-C by a type-2A protein phosphatase: specific regulation during the cell cycle in Xenopus egg extracts.

21 January 2018

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Regulation of the cdc25 protein during the cell cycle in Xenopus extracts

21 January 2018

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The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation

21 January 2018

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Closing mitosis: the functions of the Cdc14 phosphatase and its regulation

21 January 2018

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14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts

21 January 2018

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Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis

21 January 2018

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A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25.

21 January 2018

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PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation

21 January 2018

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The decision to enter mitosis: feedback and redundancy in the mitotic entry network

21 January 2018

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Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited

21 January 2018

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Temporal and spatial control of cyclin B1 destruction in metaphase

21 January 2018

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The nucleolar phosphatase Cdc14B is dispensable for chromosome segregation and mitotic exit in human cells.

21 January 2018

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The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo

21 January 2018

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Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation

21 January 2018

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Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair

21 January 2018

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Cdc14: a highly conserved family of phosphatases with non-conserved functions?

21 January 2018

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The CDC-14 phosphatase controls developmental cell-cycle arrest in C. elegans

21 January 2018

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Fission yeast Clp1p phosphatase regulates G2/M transition and coordination of cytokinesis with cell cycle progression.

21 January 2018

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Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase

21 January 2018

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Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14.

21 January 2018

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Cdc14-regulated midzone assembly controls anaphase B

21 January 2018

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Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus

21 January 2018

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Regulation of the Bfa1p-Bub2p complex at spindle pole bodies by the cell cycle phosphatase Cdc14p

21 January 2018

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Downregulation of PP2A(Cdc55) phosphatase by separase initiates mitotic exit in budding yeast.

21 January 2018

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Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase

21 January 2018

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A non-proteolytic function of separase links the onset of anaphase to mitotic exit

21 January 2018

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Mitotic exit network controls the localization of Cdc14 to the spindle pole body in Saccharomyces cerevisiae

21 January 2018

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Phosphatase 2A negatively regulates mitotic exit in Saccharomyces cerevisiae

21 January 2018

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Stabilization of microtubule dynamics at anaphase onset promotes chromosome segregation

21 January 2018

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Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase

21 January 2018

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Cdc14 phosphatase induces rDNA condensation and resolves cohesin-independent cohesion during budding yeast anaphase

21 January 2018

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Cdc14 and condensin control the dissolution of cohesin-independent chromosome linkages at repeated DNA.

21 January 2018

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Oscillations in Cdc14 release and sequestration reveal a circuit underlying mitotic exit

21 January 2018

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Interpreting spatial information and regulating mitosis in response to spindle orientation.

21 January 2018

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Monitoring spindle orientation: Spindle position checkpoint in charge.

21 January 2018

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Dbf2-Mob1 drives relocalization of protein phosphatase Cdc14 to the cytoplasm during exit from mitosis

21 January 2018

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Mitotic exit in the absence of separase activity

21 January 2018

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A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast

21 January 2018

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Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1

21 January 2018

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The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint

21 January 2018

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Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication

21 January 2018

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Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

21 January 2018

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Serine/threonine phosphatases: mechanism through structure

21 January 2018

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Emerging roles of nuclear protein phosphatases

21 January 2018

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PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail).

21 January 2018

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From promiscuity to precision: protein phosphatases get a makeover

21 January 2018

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Specificity of the polycation-stimulated (type-2A) and ATP, Mg-dependent (type-1) protein phosphatases toward substrates phosphorylated by P34cdc2 kinase

21 January 2018

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Protein phosphatase 2A1 is the major enzyme in vertebrate cell extracts that dephosphorylates several physiological substrates for cyclin-dependent protein kinases

21 January 2018

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The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase.

21 January 2018

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Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts

21 January 2018

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The M phase kinase Greatwall (Gwl) promotes inactivation of PP2A/B55delta, a phosphatase directed against CDK phosphosites

21 January 2018

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Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase

21 January 2018

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Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed

21 January 2018

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Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance

21 January 2018

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MASTL is the human orthologue of Greatwall kinase that facilitates mitotic entry, anaphase and cytokinesis

21 January 2018

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Greatwall kinase: a nuclear protein required for proper chromosome condensation and mitotic progression in Drosophila

21 January 2018

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Genome-wide survey of protein kinases required for cell cycle progression.

21 January 2018

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Greatwall kinase participates in the Cdc2 autoregulatory loop in Xenopus egg extracts

21 January 2018

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Constant regulation of both the MPF amplification loop and the Greatwall-PP2A pathway is required for metaphase II arrest and correct entry into the first embryonic cell cycle

21 January 2018

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Greatwall maintains mitosis through regulation of PP2A.

21 January 2018

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Roles of Greatwall kinase in the regulation of cdc25 phosphatase

21 January 2018

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The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A

21 January 2018

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Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis

21 January 2018

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Shugoshin collaborates with protein phosphatase 2A to protect cohesin

21 January 2018

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Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.

21 January 2018

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PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation

21 January 2018

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Structure and function of the PP2A-shugoshin interaction

21 January 2018

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Functional diversity of protein phosphatase-1, a cellular economizer and reset button

21 January 2018

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The extended PP1 toolkit: designed to create specificity

21 January 2018

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One of the protein phosphatase 1 isoenzymes in Drosophila is essential for mitosis.

21 January 2018

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Multiple protein phosphatases are required for mitosis in Drosophila.

21 January 2018

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PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation

21 January 2018

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Cell cycle-dependent phosphorylation of mammalian protein phosphatase 1 by cdc2 kinase

21 January 2018

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Phosphorylation and inactivation of protein phosphatase 1 by cyclin-dependent kinases

21 January 2018

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A phosphatase activity in Xenopus oocyte extracts preferentially dephosphorylates the MPM-2 epitope.

21 January 2018

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Calcineurin is required to release Xenopus egg extracts from meiotic M phase

21 January 2018

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Transient activation of calcineurin is essential to initiate embryonic development in Xenopus laevis.

21 January 2018

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Calcineurin and its regulation by Sra/RCAN is required for completion of meiosis in Drosophila.

21 January 2018

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Chromosomal passengers: conducting cell division

21 January 2018

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Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1.

21 January 2018

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Aurora B-mediated abscission checkpoint protects against tetraploidization

21 January 2018

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Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis

21 January 2018

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Chromosomal enrichment and activation of the aurora B pathway are coupled to spatially regulate spindle assembly

21 January 2018

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A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells

21 January 2018

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The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis

21 January 2018

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Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2

21 January 2018

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Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation

21 January 2018

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Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes

21 January 2018

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Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p

21 January 2018

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Chromatin-associated Protein Phosphatase 1 Regulates Aurora-B and Histone H3 Phosphorylation

21 January 2018

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Aurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly

21 January 2018

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Phosphatase inhibitor-2 balances protein phosphatase 1 and aurora B kinase for chromosome segregation and cytokinesis in human retinal epithelial cells

21 January 2018

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Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E.

21 January 2018

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Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase

21 January 2018

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Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosis

21 January 2018

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Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle

21 January 2018

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The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores

21 January 2018

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A novel protein phosphatase 1-dependent spindle checkpoint silencing mechanism

21 January 2018

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Protein phosphatase 1 regulates exit from the spindle checkpoint in budding yeast

21 January 2018

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Sensing centromere tension: Aurora B and the regulation of kinetochore function

21 January 2018

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Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates

21 January 2018

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Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B.

21 January 2018

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Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis

21 January 2018

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Aurora-B associated protein phosphatases as negative regulators of kinase activation

21 January 2018

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Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient

21 January 2018

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Polo-like kinases and the orchestration of cell division

21 January 2018

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The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase

21 January 2018

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Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1

21 January 2018

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Myosin phosphatase-targeting subunit 1 controls chromatid segregation

21 January 2018

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Recruitment of Polo kinase to the spindle midzone during cytokinesis requires the Feo/Klp3A complex

21 January 2018

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The reversibility of mitotic exit in vertebrate cells

21 January 2018

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Irreversibility of mitotic exit is the consequence of systems-level feedback.

21 January 2018

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Mitotic exit in mammalian cells

21 January 2018

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Regulated protein kinases and phosphatases in cell cycle decisions

21 January 2018

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Fine tuning the cell cycle: activation of the Cdk1 inhibitory phosphorylation pathway during mitotic exit

21 January 2018

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Positive feedback sharpens the anaphase switch

21 January 2018

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The protein kinase complement of the human genome

21 January 2018

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A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3.

21 January 2018

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Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation

21 January 2018

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Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation

21 January 2018

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Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites

21 January 2018

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Structural basis of protein phosphatase 1 regulation

21 January 2018

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Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

21 January 2018

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How cyclin A destruction escapes the spindle assembly checkpoint

21 January 2018

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How APC/C-Cdc20 changes its substrate specificity in mitosis

21 January 2018

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Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A.

21 January 2018

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Activation of cyclin B1-Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosis

21 January 2018

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Dual detection of chromosomes and microtubules by the chromosomal passenger complex drives spindle assembly

21 January 2018

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Hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts

21 January 2018

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Periodic cyclin-Cdk activity entrains an autonomous Cdc14 release oscillator

21 January 2018

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Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2.

21 January 2018

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How do anti-mitotic drugs kill cancer cells?

21 January 2018

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Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs.

21 January 2018

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Stochastic competition between mechanistically independent slippage and death pathways determines cell fate during mitotic arrest

21 January 2018

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Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint

21 January 2018

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Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint

21 January 2018

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Sustained spindle-assembly checkpoint response requires de novo transcription and translation of cyclin B1.

21 January 2018

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Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis.

21 January 2018

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Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage

21 January 2018

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Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly.

21 January 2018

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Mitogen-activated protein kinases phosphorylate nuclear lamins and display sequence specificity overlapping that of mitotic protein kinase p34cdc2

21 January 2018

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Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErp1 for degradation

21 January 2018

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Calmodulin-dependent protein kinase II mediates inactivation of MPF and CSF upon fertilization of Xenopus eggs

21 January 2018

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Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin

21 January 2018

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Mechanisms of chromosome behaviour during mitosis

21 January 2018

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Identification of protein phosphatase 1 as a mitotic lamin phosphatase

31 March 2020

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Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast

31 March 2020

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Exit from Mitosis in Budding Yeast

31 March 2020

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Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a

31 March 2020

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S. pombe aurora kinase/survivin is required for chromosome condensation and the spindle checkpoint attachment response

31 March 2020

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Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos.

31 March 2020

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12 December 2020

An evolutionary conserved checkpoint controls abscission timing.

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12 December 2020

Visualization of kinase activity with FRET-based activity biosensors

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12 December 2020

CDC14 of Saccharomyces cerevisiae. Cloning, sequence analysis, and transcription during the cell cycle

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12 December 2020

Protein phosphatase 1--targeted in many directions

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12 December 2020

C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding

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12 December 2020

Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2.

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12 December 2020

Flp1, a fission yeast orthologue of the s. cerevisiae CDC14 gene, is not required for cyclin degradation or rum1p stabilisation at the end of mitosis

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12 December 2020

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12 December 2020

Identifiers

DOI

10.1038/NRM3149

1 reference

PubMed ID

21750572

Dimensions Publication ID

25 August 2017

0 references

1 reference

PubMed ID

21750572