(Q48529643)

12 February 2018

review article

1 reference

https://api.crossref.org/works/10.1038/NRM3132

title

Cubism and the cell cycle: the many faces of the APC/C (English)

1 reference

Jonathon Noe Joseph Pines

3 December 2024

author

series ordinal

1

1 reference

12 February 2018

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21633387

3 December 2024

publication date

2 June 2011

1 reference

12 February 2018

full work available at URL

http://www.nature.com/articles/nrm3132.pdf

1 reference

https://api.crossref.org/works/10.1038/NRM3132

http://www.nature.com/articles/nrm3132

3 December 2024

1 reference

https://api.crossref.org/works/10.1038/NRM3132

Nature Reviews Molecular Cell Biology

3 December 2024

published in

1 reference

12 February 2018

volume

12

1 reference

12 February 2018

issue

7

1 reference

12 February 2018

page(s)

427-438

1 reference

12 February 2018

Driving the cell cycle with a minimal CDK control network

cites work

1 reference

CDK Inactivation Is the Only Essential Function of the APC/C and the Mitotic Exit Network Proteins for Origin Resetting during Mitosis

31 March 2020

1 reference

Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle.

31 March 2020

1 reference

The spindle-assembly checkpoint in space and time

31 March 2020

1 reference

Regulation of APC/C activators in mitosis and meiosis

31 March 2020

1 reference

Control of the oocyte-to-embryo transition by the ubiquitin-proteolytic system in mouse and C. elegans

31 March 2020

1 reference

Structural basis for the subunit assembly of the anaphase-promoting complex

31 March 2020

1 reference

TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1

31 March 2020

1 reference

An architectural map of the anaphase-promoting complex

31 March 2020

1 reference

The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex

31 March 2020

1 reference

APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex

31 March 2020

1 reference

Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1.

31 March 2020

1 reference

Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation

31 March 2020

1 reference

Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex

31 March 2020

1 reference

Three-dimensional structure of the anaphase-promoting complex

31 March 2020

1 reference

Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor

31 March 2020

1 reference

Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1.

31 March 2020

1 reference

The Doc1 subunit is a processivity factor for the anaphase-promoting complex.

31 March 2020

1 reference

The APC subunit Doc1 promotes recognition of the substrate destruction box.

31 March 2020

1 reference

Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition.

31 March 2020

1 reference

Coactivator functions in a stoichiometric complex with anaphase-promoting complex/cyclosome to mediate substrate recognition

31 March 2020

1 reference

Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism.

31 March 2020

1 reference

How APC/C-Cdc20 changes its substrate specificity in mitosis

31 March 2020

1 reference

CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis

31 March 2020

1 reference

Positive feedback sharpens the anaphase switch

31 March 2020

1 reference

Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase

31 March 2020

1 reference

BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis

31 March 2020

1 reference

The role of the destruction box and its neighbouring lysine residues in cyclin B for anaphase ubiquitin-dependent proteolysis in fission yeast: defining the D-box receptor

31 March 2020

1 reference

Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates

31 March 2020

1 reference

Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex

31 March 2020

1 reference

The unique N terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances checkpoint regulation of the APC.

31 March 2020

1 reference

Identification of a physiological E2 module for the human anaphase-promoting complex

31 March 2020

1 reference

Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin.

31 March 2020

1 reference

UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit

31 March 2020

1 reference

UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex

31 March 2020

1 reference

Two Ubiquitin-Conjugating Enzymes, UbcP1/Ubc4 and UbcP4/Ubc11, Have Distinct Functions for Ubiquitination of Mitotic Cyclin

31 March 2020

1 reference

The E2-C vihar is required for the correct spatiotemporal proteolysis of cyclin B and itself undergoes cyclical degradation.

31 March 2020

1 reference

Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase

31 March 2020

1 reference

Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry.

31 March 2020

1 reference

Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology

31 March 2020

1 reference

Segregating sister genomes: the molecular biology of chromosome separation

31 March 2020

1 reference

Geminin, an inhibitor of DNA replication, is degraded during mitosis

31 March 2020

1 reference

Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit

31 March 2020

1 reference

Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells

31 March 2020

1 reference

The D-Box-activating domain (DAD) is a new proteolysis signal that stimulates the silent D-Box sequence of Aurora-A.

31 March 2020

1 reference

Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex

31 March 2020

1 reference

Mitotic regulation of the human anaphase-promoting complex by phosphorylation

31 March 2020

1 reference

Phosphorylation of the cyclosome is required for its stimulation by Fizzy/cdc20.

31 March 2020

1 reference

Cdc28 activates exit from mitosis in budding yeast.

31 March 2020

1 reference

Two Redundant Oscillatory Mechanisms in the Yeast Cell Cycle

31 March 2020

1 reference

PKA and MPF-activated polo-like kinase regulate anaphase-promoting complex activity and mitosis progression.

31 March 2020

1 reference

Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex

31 March 2020

1 reference

Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1

31 March 2020

1 reference

Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome

31 March 2020

1 reference

Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C

31 March 2020

1 reference

The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1

31 March 2020

1 reference

A Role for the Fizzy/Cdc20 Family of Proteins in Activation of the APC/C Distinct from Substrate Recruitment

31 March 2020

1 reference

Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation

31 March 2020

1 reference

Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

31 March 2020

1 reference

Activation of cyclin B1-Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosis

31 March 2020

1 reference

Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A.

31 March 2020

1 reference

Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint

31 March 2020

1 reference

How cyclin A destruction escapes the spindle assembly checkpoint

31 March 2020

1 reference

Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

31 March 2020

1 reference

The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores

31 March 2020

1 reference

Getting down to the phosphorylated 'nuts and bolts' of spindle checkpoint signalling

31 March 2020

1 reference

The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint

31 March 2020

1 reference

Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding

31 March 2020

1 reference

Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex

31 March 2020

1 reference

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

31 March 2020

1 reference

Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint

31 March 2020

1 reference

Mad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpoint

31 March 2020

1 reference

Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation

31 March 2020

1 reference

Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities

31 March 2020

1 reference

Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae

31 March 2020

1 reference

The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction

31 March 2020

1 reference

APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation.

31 March 2020

1 reference

The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex

31 March 2020

1 reference

The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation.

31 March 2020

1 reference

BUBR1 deficiency results in abnormal megakaryopoiesis

31 March 2020

1 reference

Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2

31 March 2020

1 reference

Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C

31 March 2020

1 reference

Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression

31 March 2020

1 reference

Temporal and spatial control of cyclin B1 destruction in metaphase

31 March 2020

1 reference

The anaphase promoting complex/cyclosome is recruited to centromeres by the spindle assembly checkpoint.

31 March 2020

1 reference

The disappearance of cyclin B at the end of mitosis is regulated spatially in Drosophila cells

31 March 2020

1 reference

Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase

31 March 2020

1 reference

Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos

31 March 2020

1 reference

Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly.

31 March 2020

1 reference

Inhibitory phosphorylation of cyclin-dependent kinase 1 as a compensatory mechanism for mitosis exit

31 March 2020

1 reference

Strong inducible knockdown of APC/CCdc20 does not cause mitotic arrest in human somatic cells

31 March 2020

1 reference

The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates

31 March 2020

1 reference

Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.

31 March 2020

1 reference

Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosis

31 March 2020

1 reference

Genomic stability and tumour suppression by the APC/C cofactor Cdh1.

31 March 2020

1 reference

APC/C Cdh1 targets aurora kinase to control reorganization of the mitotic spindle at anaphase

31 March 2020

1 reference

Drosophila fizzy-related Down-Regulates Mitotic Cyclins and Is Required for Cell Proliferation Arrest and Entry into Endocycles

31 March 2020

1 reference

APC(ste9/srw1) promotes degradation of mitotic cyclins in G(1) and is inhibited by cdc2 phosphorylation.

31 March 2020

1 reference

Yeast Hct1 Is a Regulator of Clb2 Cyclin Proteolysis

31 March 2020

1 reference

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.

31 March 2020

1 reference

At the interface between signaling and executing anaphase--Cdc14 and the FEAR network

31 March 2020

1 reference

The processivity of multiubiquitination by the APC determines the order of substrate degradation.

31 March 2020

1 reference

Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase

31 March 2020

1 reference

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

31 March 2020

1 reference

Apc10 and Ste9/Srw1, two regulators of the APC-cyclosome, as well as the CDK inhibitor Rum1 are required for G1 cell-cycle arrest in fission yeast

31 March 2020

1 reference

Fission Yeast Ste9, a Homolog of Hct1/Cdh1 and Fizzy-related, Is a Novel Negative Regulator of Cell Cycle Progression during G1-Phase

31 March 2020

1 reference

APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit

31 March 2020

1 reference

Systematic identification of pathways that couple cell growth and division in yeast

31 March 2020

1 reference

Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells

31 March 2020

1 reference

Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair

31 March 2020

1 reference

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint

31 March 2020

1 reference

A fission yeast homolog of CDC20/p55CDC/Fizzy is required for recovery from DNA damage and genetically interacts with p34cdc2

31 March 2020

1 reference

Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14.

31 March 2020

1 reference

Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex

31 March 2020

1 reference

Terminal mitoses require negative regulation of Fzr/Cdh1 by Cyclin A, preventing premature degradation of mitotic cyclins and String/Cdc25.

31 March 2020

1 reference

Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex

31 March 2020

1 reference

E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)

31 March 2020

1 reference

The APC/C inhibitor, Emi1, is essential for prevention of rereplication

31 March 2020

1 reference

Acm1 is a negative regulator of the CDH1-dependent anaphase-promoting complex/cyclosome in budding yeast.

31 March 2020

1 reference

Rca1 inhibits APC-Cdh1(Fzr) and is required to prevent cyclin degradation in G2.

31 March 2020

1 reference

Pseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation

31 March 2020

1 reference

Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1.

31 March 2020

1 reference

Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor

31 March 2020

1 reference

Emi2-mediated inhibition of E2-substrate ubiquitin transfer by the anaphase-promoting complex/cyclosome through a D-box-independent mechanism

31 March 2020

1 reference

UbcH10 has a rate-limiting role in G1 phase but might not act in the spindle checkpoint or as part of an autonomous oscillator.

31 March 2020

1 reference

The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles

31 March 2020

1 reference

Mouse emi1 has an essential function in mitotic progression during early embryogenesis

31 March 2020

1 reference

Cyclin E ablation in the mouse

31 March 2020

1 reference

Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation

31 March 2020

1 reference

Cdh1-APC controls axonal growth and patterning in the mammalian brain

31 March 2020

1 reference

Independent regulation of synaptic size and activity by the anaphase-promoting complex

31 March 2020

1 reference

A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation

31 March 2020

1 reference

BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C(Cdc20) in interphase

31 March 2020

1 reference

Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling.

31 March 2020

1 reference

A Novel Yeast Screen for Mitotic Arrest Mutants IdentifiesDOC1, a New Gene Involved in Cyclin Proteolysis

31 March 2020

1 reference

31 March 2020

1 reference

Mitosis: a matter of getting rid of the right protein at the right time

31 March 2020

1 reference

Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1

31 March 2020

1 reference

Cohesin cleavage by separase required for anaphase and cytokinesis in human cells

31 March 2020

1 reference

Tumor susceptibility of Rassf1a knockout mice

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21633387

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRM3132

1 reference

12 February 2018

1 reference

12 February 2018