(Q37906733)

25 August 2017

1 reference

title

Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications (English)

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25 August 2017

Young-Sam Keum

1

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25 August 2017

language of work or name

English

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publication date

1 July 2011

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Annals of the New York Academy of Sciences

25 August 2017

published in

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25 August 2017

volume

1229

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25 August 2017

page(s)

184-189

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Cancer chemoprevention with dietary phytochemicals

25 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure

21 January 2018

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Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: implication of induction of Nrf2, HO-1 and apoptosis and the suppression of Akt-dependent ki

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action.

21 January 2018

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Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China

21 January 2018

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Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

Multi-targeted prevention of cancer by sulforaphane

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution

21 January 2018

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

Modification of keap1 cysteine residues by sulforaphane

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

Phosphorylation of tyrosine 568 controls nuclear export of Nrf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2011.06092.X

10.1111/J.1749-6632.2011.06092.X

21 January 2018

Identifiers

DOI

1 reference

25 August 2017

1 reference