(Q37913989)

25 August 2017

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title

Pharmacogenetics: implications for therapy in rheumatic diseases (English)

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25 August 2017

Lesley Davila

1

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25 August 2017

Prabha Ranganathan

series ordinal

2

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25 August 2017

language of work or name

English

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publication date

9 August 2011

1 reference

Nature Reviews Rheumatology

25 August 2017

published in

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25 August 2017

volume

7

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25 August 2017

issue

9

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25 August 2017

page(s)

537-550

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https://scigraph.springernature.com/pub.10.1038/nrrheum.2011.117

25 August 2017

exact match

0 references

cites work

STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Pharmacogenomics: translating functional genomics into rational therapeutics

21 January 2018

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Pharmacogenomics: unlocking the human genome for better drug therapy

21 January 2018

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A long-term prospective study of the use of methotrexate in rheumatoid arthritis. Update after a mean of fifty-three months

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Mammalian ABC transporters in health and disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Methotrexate in rheumatoid arthritis: an update with focus on mechanisms involved in toxicity

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Molecular action of methotrexate in inflammatory diseases

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Influence of sulphasalazine, methotrexate, and the combination of both on plasma homocysteine concentrations in patients with rheumatoid arthritis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

The C677T mutation in the methylenetetrahydrofolate reductase gene: a genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Metaanalysis of methylenetetrahydrofolate reductase (MTHFR) polymorphisms affecting methotrexate toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Associations between the C677T and A1298C polymorphisms of MTHFR and the efficacy and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Regulatory functions of 3'UTRs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Functional polymorphisms and methotrexate treatment outcome in recent-onset rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Azathioprine-induced fatal myelosuppression in systemic lupus erythematosus patient carrying TPMT*3C polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Are patients with intermediate TPMT activity at increased risk of myelosuppression when taking thiopurine medications?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Identification of thiopurine methyltransferase (TPMT) polymorphisms cannot predict myelosuppression in systemic lupus erythematosus patients taking azathioprine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Polymorphism of human acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Adverse reactions during salicylazosulfapyridine therapy and the relation with drug metabolism and acetylator phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Chloroquine treatment influences proinflammatory cytokine levels in systemic lupus erythematosus patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Chloroquine interferes with lipopolysaccharide-induced TNF-alpha gene expression by a nonlysosomotropic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Differential effect of IL10 and TNF{alpha} genotypes on determining susceptibility to discoid and systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Interindividual variations in constitutive interleukin-10 messenger RNA and protein levels and their association with genetic polymorphisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

An investigation of polymorphism in the interleukin-10 gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Cytokine polymorphisms influence treatment outcomes in SLE patients treated with antimalarial drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

The effect of exon (19C>A) dihydroorotate dehydrogenase gene polymorphism on rheumatoid arthritis treatment with leflunomide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Dihydroorotate dehydrogenase polymorphism influences the toxicity of leflunomide treatment in patients with rheumatoid arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Estrogens interfere with leflunomide modulation of cytokine production by human activated monocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Sex hormones modulate the effects of Leflunomide on cytokine production by cultures of differentiated monocyte/macrophages and synovial macrophages from rheumatoid arthritis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Genetic polymorphism of CYP1A2 and the toxicity of leflunomide treatment in rheumatoid arthritis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Cytochrome P450 pharmacogenetics as a predictor of toxicity and clinical response to pulse cyclophosphamide in lupus nephritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Relationship of glutathione S-transferase genotypes with side-effects of pulsed cyclophosphamide therapy in patients with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

21 January 2018

Glutathione transferases

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Is there a future for TNF promoter polymorphisms?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Polymorphism of the human TNF-alpha promoter--random variation or functional diversity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

In vivo characterization of regulatory polymorphisms by allele-specific quantification of RNA polymerase loading

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Highly informative typing of the human TNF locus using six adjacent polymorphic markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

FcgammaRIIIA-158V and rheumatoid arthritis: a confirmation study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

The F158V polymorphism in FcgammaRIIIA shows disparate associations with rheumatoid arthritis in two genetically distinct populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Association between polymorphism in IgG Fc receptor IIIa coding gene and biological response to infliximab in Crohn's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Associations between tumor necrosis factor-alpha (TNF-alpha) -308 and -238 G/A polymorphisms and shared epitope status and responsiveness to TNF-alpha blockers in rheumatoid arthritis: a metaanalysis update

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Polymorphisms spanning the TNFR2 and TACE genes do not contribute towards variable anti-TNF treatment response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Association of the major histocompatibility complex with response to infliximab therapy in rheumatoid arthritis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

CD45: a critical regulator of signaling thresholds in immune cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Expression and activation of mitogen-activated protein kinase kinases-3 and -6 in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Monoclonal anti-CD20 antibodies: mechanisms of action and monitoring of biological effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

FcγRIIIa and FcγRIIa polymorphisms do not predict response to rituximab in B-cell chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

The relationship of FcgammaRIIIa genotype to degree of B cell depletion by rituximab in the treatment of systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Racial or ethnic differences in allele frequencies of single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene and their influence on response to methotrexate in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Conference Scene: The great debate: genome-wide association studies in pharmacogenetics research, good or bad?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Assessing the cost-effectiveness of pharmacogenomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Methotrexate pharmacogenetics: the first step toward individualized therapy in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

IL-1B and IL-1RN gene polymorphisms in rheumatoid arthritis: relationship with protein plasma levels and response to therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Fcγ receptor type IIIA genotype and response to tumor necrosis factor α–blocking agents in patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Efficacy of low-dose methotrexate in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Human thymidylate synthetase--III. Effects of methotrexate and folate analogs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Functional Analysis and DNA Polymorphism of the Tandemly Repeated Sequences in the 5'-terminal Regulatory Region of the Human Gene for Thymidylate Synthase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

The role of thymidylate synthase as a molecular biomarker

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Reduced thiopurine methyltransferase activity and development of side effects of azathioprine treatment in patients with rheumatoid arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Variables affecting efficacy and toxicity of sulphasalazine in rheumatoid arthritis. A review.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Polymorphisms of NAT2 in relation to sulphasalazine-induced agranulocytosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Validation of the associations between single nucleotide polymorphisms or haplotypes and responses to disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: a proposal for prospective pharmacogenomic study in clinical practice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

NAT2 genotyping and efficacy of sulfasalazine in patients with chronic discoid lupus erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

The effect ofESR1andESR2gene polymorphisms on the outcome of rheumatoid arthritis treatment with leflunomide

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Tumor necrosis factor gene polymorphism and septic shock in surgical infection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Secretion of tumour necrosis factor alpha and lymphotoxin alpha in relation to polymorphisms in the TNF genes and HLA-DR alleles. Relevance for inflammatory bowel disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

TNF-alpha promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Association of tumor necrosis factor receptor type II polymorphism 196R with Systemic lupus erythematosus in the Japanese: molecular and functional analysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

The 158V polymorphism of Fc gamma receptor type IIIA in early rheumatoid arthritis: increased susceptibility and severity in male patients (the Swedish TIRA project)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

The -308 tumour necrosis factor-alpha gene polymorphism predicts therapeutic response to TNFalpha-blockers in rheumatoid arthritis and spondyloarthritis patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Tumour necrosis factor (TNF)alpha -308 G/G promoter polymorphism and TNFalpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

CD45-induced tumor necrosis factor alpha production in monocytes is phosphatidylinositol 3-kinase-dependent and nuclear factor-kappaB-independent

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

BAFF-modulated repopulation of B lymphocytes in the blood and salivary glands of rituximab-treated patients with Sjögren's syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.117

Adverse effects of sulfasalazine in patients with rheumatoid arthritis are associated with diplotype configuration at the N-acetyltransferase 2 gene.

31 March 2020

1 reference

12 December 2020

Tumor necrosis factor-alpha gene polymorphism in severe and mild-moderate rheumatoid arthritis.

1 reference

12 December 2020

ABCB1 C3435T polymorphism influences methotrexate sensitivity in rheumatoid arthritis patients

1 reference

12 December 2020

The human ATP-binding cassette (ABC) transporter superfamily.

1 reference

12 December 2020

Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers

1 reference

12 December 2020

Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians

1 reference

12 December 2020

Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate

1 reference

12 December 2020

Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis.

1 reference

12 December 2020

Searching expressed sequence tag databases: discovery and confirmation of a common polymorphism in the thymidylate synthase gene.

1 reference

12 December 2020

Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy

1 reference

12 December 2020

Tumor necrosis factor-alpha receptor II polymorphism in patients from southern Europe with mild-moderate and severe rheumatoid arthritis.

1 reference

12 December 2020

Effects of DMARDs on IL-1Ra levels in rheumatoid arthritis: is there any evidence?

1 reference

12 December 2020

Polymorphisms in the thymidylate synthase and methylenetetrahydrofolate reductase genes and sensitivity to the low-dose methotrexate therapy in patients with rheumatoid arthritis.

1 reference

12 December 2020

Pretreatment cytokine profiles of peripheral blood mononuclear cells and serum from patients with rheumatoid arthritis in different american college of rheumatology response groups to methotrexate

1 reference

12 December 2020

Practical pharmacogenetics: the cost effectiveness of screening for thiopurine s-methyltransferase polymorphisms in patients with rheumatological conditions treated with azathioprine

1 reference

12 December 2020

Genetic polymorphisms of thiopurine S-methyltransferase in a cohort of patients with systemic autoimmune diseases.

1 reference

12 December 2020

Role of Fcgamma receptors IIA, IIIA, and IIIB in susceptibility to rheumatoid arthritis

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRRHEUM.2011.117

1 reference

25 August 2017

1 reference