(Q37919430)

25 August 2017

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title

Rab8 GTPase as a regulator of cell shape (English)

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25 August 2017

Johan Peränen

1

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25 August 2017

9 September 2011

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25 August 2017

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25 August 2017

68

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25 August 2017

10

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25 August 2017

527-539

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Inhibition of metabotropic glutamate receptor signaling by the huntingtin-binding protein optineurin

25 August 2017

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7 January 2021

The Rab8 GTPase selectively regulates AP-1B-dependent basolateral transport in polarized Madin-Darby canine kidney cells

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7 January 2021

Differential role of Rab proteins in ciliary trafficking: Rab23 regulates smoothened levels

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7 January 2021

Myosin VI and its binding partner optineurin are involved in secretory vesicle fusion at the plasma membrane.

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7 January 2021

MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway.

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7 January 2021

Functional compartmentalization of endosomal trafficking for the synaptic delivery of AMPA receptors during long-term potentiation

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7 January 2021

A molecular network for de novo generation of the apical surface and lumen

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7 January 2021

Specific interactions of Mss4 with members of the Rab GTPase subfamily.

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7 January 2021

A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane

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7 January 2021

Rab8 regulates the actin-based movement of melanosomes

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7 January 2021

In-frame deletion in a novel centrosomal/ciliary protein CEP290/NPHP6 perturbs its interaction with RPGR and results in early-onset retinal degeneration in the rd16 mouse

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7 January 2021

Molecular cloning of YPT1/SEC4-related cDNAs from an epithelial cell line

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7 January 2021

Myosin VI and optineurin are required for polarized EGFR delivery and directed migration

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7 January 2021

Function of the ypt2 gene in the exocytic pathway of Schizosaccharomyces pombe

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7 January 2021

Rab11 is required for trans-golgi network-to-plasma membrane transport and a preferential target for GDP dissociation inhibitor

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7 January 2021

Rab8b and its interacting partner TRIP8b are involved in regulated secretion in AtT20 cells

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7 January 2021

Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice

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7 January 2021

R-Ras regulates beta1-integrin trafficking via effects on membrane ruffling and endocytosis

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7 January 2021

Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice.

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7 January 2021

Mutant huntingtin impairs post-Golgi trafficking to lysosomes by delocalizing optineurin/Rab8 complex from the Golgi apparatus

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7 January 2021

Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling

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7 January 2021

Rab8 interacts with distinct motifs in alpha2B- and beta2-adrenergic receptors and differentially modulates their transport

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7 January 2021

Rab8 is involved in zymogen granule formation in pancreatic acinar AR42J cells.

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7 January 2021

The cytoplasmic tail of fibrocystin contains a ciliary targeting sequence

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7 January 2021

The C-terminal end of R-Ras contains a focal adhesion targeting signal

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7 January 2021

Local control of AMPA receptor trafficking at the postsynaptic terminal by a small GTPase of the Rab family

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7 January 2021

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

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7 January 2021

Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers

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7 January 2021

Integrins traffic rapidly via circular dorsal ruffles and macropinocytosis during stimulated cell migration

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7 January 2021

Cell adhesion: the molecular basis of tissue architecture and morphogenesis

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7 January 2021

Differential gene and protein expression in primary breast malignancies and their lymph node metastases as revealed by combined cDNA microarray and tissue microarray analysis

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7 January 2021

FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis

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7 January 2021

Purification and functional properties of a Rab8-specific GEF (Rabin3) in action remodeling and polarized transport

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7 January 2021

A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport

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7 January 2021

Characterization of the Rab8-specific membrane traffic route linked to protrusion formation

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7 January 2021

Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form

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7 January 2021

Rab8 regulates basolateral secretory, but not recycling, traffic at the recycling endosome

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7 January 2021

Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking

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7 January 2021

A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1

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7 January 2021

Protein transport to the dendritic plasma membrane of cultured neurons is regulated by rab8p

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7 January 2021

Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane

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7 January 2021

A deficiency of the small GTPase rab8 inhibits membrane traffic in developing neurons.

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7 January 2021

Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation

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7 January 2021

GTPases involved in vesicular trafficking: structures and mechanisms

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7 January 2021

Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.

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7 January 2021

Myosin Vc is a molecular motor that functions in secretory granule trafficking

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7 January 2021

Involvement of Rab13 and JRAB/MICAL-L2 in epithelial cell scattering.

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7 January 2021

Mutant presenilin (A260V) affects Rab8 in PC12D cell

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7 January 2021

CEP290 interacts with the centriolar satellite component PCM-1 and is required for Rab8 localization to the primary cilium

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7 January 2021

Coordination of Rab8 and Rab11 in primary ciliogenesis

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7 January 2021

Negative guidance factor-induced macropinocytosis in the growth cone plays a critical role in repulsive axon turning

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7 January 2021

The primary cilium as a cellular signaling center: lessons from disease

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7 January 2021

Rab GTPases containing a CAAX motif are processed post-geranylgeranylation by proteolysis and methylation.

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7 January 2021

The fast and slow ups and downs of HCN channel regulation.

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7 January 2021

Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells

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7 January 2021

Rab8 regulates ABCA1 cell surface expression and facilitates cholesterol efflux in primary human macrophages

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7 January 2021

Structure and function of the Lowe syndrome protein OCRL1.

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7 January 2021

GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase

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7 January 2021

Mutations of optineurin in amyotrophic lateral sclerosis

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7 January 2021

Virus entry by endocytosis

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7 January 2021

AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain

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7 January 2021

Screening of OPTN in French familial amyotrophic lateral sclerosis

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7 January 2021

EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts

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7 January 2021

Mutant rab8 Impairs docking and fusion of rhodopsin-bearing post-Golgi membranes and causes cell death of transgenic Xenopus rods

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7 January 2021

Interaction of retinitis pigmentosa GTPase regulator (RPGR) with RAB8A GTPase: implications for cilia dysfunction and photoreceptor degeneration

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7 January 2021

MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity.

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7 January 2021

A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis

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7 January 2021

Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant

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7 January 2021

EHD1 regulates cholesterol homeostasis and lipid droplet storage

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7 January 2021

Remodeling epithelial cell organization: transitions between front-rear and apical-basal polarity

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7 January 2021

Rho GTPases control polarity, protrusion, and adhesion during cell movement

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7 January 2021

Elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8.

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7 January 2021

Membrane organization and dynamics in cell polarity

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7 January 2021

Ypt32 recruits the Sec4p guanine nucleotide exchange factor, Sec2p, to secretory vesicles; evidence for a Rab cascade in yeast

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7 January 2021

Cdc42 localization and cell polarity depend on membrane traffic

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7 January 2021

High-precision mapping of protein protein interfaces: an integrated genetic strategy combining en masse mutagenesis and DNA-level parallel analysis on a yeast two-hybrid platform

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7 January 2021

An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration

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7 January 2021

Recycling endosomes supply AMPA receptors for LTP

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7 January 2021

Impairment of protein trafficking upon overexpression and mutation of optineurin

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7 January 2021

Rab8 promotes polarized membrane transport through reorganization of actin and microtubules in fibroblasts

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7 January 2021

Expression, purification, and properties of Rab8 function in actin cortical skeleton organization and polarized transport

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7 January 2021

Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures

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7 January 2021

ADP-ribosylation factor 6 regulates a novel plasma membrane recycling pathway

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7 January 2021

Collapsin response mediator protein-2 (Crmp2) regulates trafficking by linking endocytic regulatory proteins to dynein motors

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7 January 2021

GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells

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7 January 2021

In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase

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7 January 2021

Adult-onset primary open-angle glaucoma caused by mutations in optineurin

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7 January 2021

Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1

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7 January 2021

Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3.

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7 January 2021

Alternative splicing in class V myosins determines association with Rab10.

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7 January 2021

Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization.

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7 January 2021

Huntington's disease: from molecular pathogenesis to clinical treatment

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7 January 2021

Roles for the recycling endosome, Rab8, and Rab11 in hantavirus release from epithelial cells

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7 January 2021

Loss-of-function of MYO5B is the main cause of microvillus inclusion disease: 15 novel mutations and a CaCo-2 RNAi cell model.

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7 January 2021

Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis

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7 January 2021

Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras.

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7 January 2021

Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction

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7 January 2021

The Rab8 GTPase regulates apical protein localization in intestinal cells

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7 January 2021

RhoA regulates peroxisome association to microtubules and the actin cytoskeleton

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7 January 2021

ARF6-mediated endosome recycling reverses lipid accumulation defects in Niemann-Pick Type C disease

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7 January 2021

MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling

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7 January 2021

The primary cilium as the cell's antenna: signaling at a sensory organelle

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7 January 2021

Rab GTPases as coordinators of vesicle traffic

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7 January 2021

Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells

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7 January 2021

CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease

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7 January 2021

Retinal degeneration and failure of photoreceptor outer segment formation in mice with targeted deletion of the Joubert syndrome gene, Ahi1

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7 January 2021

Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome

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7 January 2021

Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases

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7 January 2021

Identification and characterisation of novel Mss4-binding Rab GTPases

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7 January 2021

Myosin Vc, a member of the actin motor family associated with Rab8, is involved in the release of DV2 from HepG2 cells

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7 January 2021

The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions

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7 January 2021

Functional dissection of Rab GTPases involved in primary cilium formation

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7 January 2021

Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors

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7 January 2021

Mechanistic insights into Bardet-Biedl syndrome, a model ciliopathy

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7 January 2021

Identifiers

DOI

10.1002/CM.20529

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25 August 2017

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PubMed ID

21850707