(Q37920144)

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Triheptanoin--a medium chain triglyceride with odd chain fatty acids: a new anaplerotic anticonvulsant treatment?

scientific article published on 19 August 2011

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11 February 2020

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Triheptanoin--a medium chain triglyceride with odd chain fatty acids: a new anaplerotic anticonvulsant treatment? (English)

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11 February 2020

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11 February 2020

Ursula Sonnewald

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Ursula Sonnewald

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11 February 2020

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19 August 2011

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11 February 2020

Epilepsy Research

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11 February 2020

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11 February 2020

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11 February 2020

239-244

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11 February 2020

Pyruvate carboxylation in different model systems studied by (13)C MRS.

1 reference

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6 September 2017

Adenosine, ketogenic diet and epilepsy: the emerging therapeutic relationship between metabolism and brain activity

1 reference

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6 September 2017

Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats. II. Effects on lipolysis, glucose production, and liver acyl-CoA profile

1 reference

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6 September 2017

Evidence for catabolic pathway of propionate metabolism in CNS: expression pattern of methylmalonyl-CoA mutase and propionyl-CoA carboxylase alpha-subunit in developing and adult rat brain

1 reference

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6 September 2017

Interrelations between C4 ketogenesis, C5 ketogenesis, and anaplerosis in the perfused rat liver

1 reference

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Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy models

1 reference

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Mouse models: the ketogenic diet and polyunsaturated fatty acids

1 reference

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6 September 2017

Oral administration of fructose-1,6-diphosphate has anticonvulsant activity

1 reference

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6 September 2017

Carnitine palmitoyltransferase II deficiency: successful anaplerotic diet therapy

1 reference

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6 September 2017

Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A.

1 reference

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6 September 2017

Are purines mediators of the anticonvulsant/neuroprotective effects of ketogenic diets?

1 reference

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6 September 2017

The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial

1 reference

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6 September 2017

Effects of short-term and long-term treatment with medium- and long-chain triglycerides ketogenic diet on cortical spreading depression in young rats.

1 reference

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6 September 2017

Efficacy of the ketogenic diet in the 6-Hz seizure test.

1 reference

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6 September 2017

The neuropharmacology of the ketogenic diet

1 reference

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6 September 2017

2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure

1 reference

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6 September 2017

Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet

1 reference

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6 September 2017

Anaplerotic diet therapy in inherited metabolic disease: therapeutic potential

1 reference

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6 September 2017

Anaplerotic molecules: current and future

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422680

6 September 2017

Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422680

6 September 2017

Pyruvate carboxylase deficiency: clinical and biochemical response to anaplerotic diet therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422680

6 September 2017

Assessing the reversibility of the anaplerotic reactions of the propionyl-CoA pathway in heart and liver

1 reference

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6 September 2017

Treatment of cardiomyopathy and rhabdomyolysis in long-chain fat oxidation disorders using an anaplerotic odd-chain triglyceride

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422680

6 September 2017

The key role of anaplerosis and cataplerosis for citric acid cycle function.

1 reference

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6 September 2017

Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy

1 reference

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6 September 2017

Isolation of cDNA clones coding for the alpha and beta chains of human propionyl-CoA carboxylase: chromosomal assignments and DNA polymorphisms associated with PCCA and PCCB genes

1 reference

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6 September 2017

Epilepsy in patients with propionic acidemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422680

14 September 2017

Comparative anticonvulsant efficacy in the corneal kindled mouse model of partial epilepsy: Correlation with other seizure and epilepsy models

1 reference

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23 June 2018

Anticonvulsant effects of a triheptanoin diet in two mouse chronic seizure models

1 reference

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23 June 2018

Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy

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Elimination and replenishment of tricarboxylic acid-cycle intermediates in myocardium

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23 June 2018

Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study

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23 June 2018

Pyruvate carboxylase activity in primary cultures of astrocytes and neurons.

1 reference

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Seizures produced by pilocarpine in mice: a behavioral, electroencephalographic and morphological analysis

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Pyruvate carboxylase: an astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools

1 reference

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Chronic ketosis and cerebral metabolism.

1 reference

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Adult Polyglucosan Body Disease (APBD): Anaplerotic diet therapy (Triheptanoin) and demonstration of defective methylation pathways

1 reference

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Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models.

1 reference

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Anticonvulsant profile of a balanced ketogenic diet in acute mouse seizure models

1 reference

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Fructose-1,6-bisphosphate has anticonvulsant activity in models of acute seizures in adult rats.

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Propionate increases neuronal histone acetylation, but is metabolized oxidatively by glia. Relevance for propionic acidemia.

1 reference

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Effects of the novel antiepileptic drug lacosamide on the development of amygdala kindling in rats

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Metabolism is normal in astrocytes in chronically epileptic rats: a (13)C NMR study of neuronal-glial interactions in a model of temporal lobe epilepsy

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Quantitative assessment of anaplerosis from propionate in pig heart in vivo

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Corneal kindling in mice: behavioral and pharmacological differences to conventional kindling

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Validation of corneally kindled mice: a sensitive screening model for partial epilepsy in man.

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Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilespy

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Limbic structures show altered glial-neuronal metabolism in the chronic phase of kainate induced epilepsy

1 reference

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12 December 2020

based on heuristic

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Immunocytochemical examination of neural rat and mouse primary cultures using monoclonal antibodies raised against pyruvate carboxylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21855298

12 December 2020

based on heuristic

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Metabolism of R-beta-hydroxypentanoate and of beta-ketopentanoate in conscious dogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/21855298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizure models

1 reference

https://pubmed.ncbi.nlm.nih.gov/21855298

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.EPLEPSYRES.2011.05.023

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21855298%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21855298%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21855298%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

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