(Q37930388)

25 August 2017

1 reference

title

Standard of care therapy for malignant glioma and its effect on tumor and stromal cells (English)

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25 August 2017

T S Jones

1

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PubMed ID

21909136

25 August 2017

E C Holland

series ordinal

2

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PubMed ID

21909136

25 August 2017

language of work or name

English

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publication date

12 September 2011

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25 August 2017

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25 August 2017

31

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25 August 2017

16

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25 August 2017

1995-2006

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https://scigraph.springernature.com/pub.10.1038/onc.2011.398

25 August 2017

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TGF-β Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma

21 January 2018

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Experimental approaches for the treatment of malignant gliomas

21 January 2018

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Expression of chemokine receptors in the rat brain.

21 January 2018

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Treg depletion with a low-dose metronomic temozolomide regimen in a rat glioma model

21 January 2018

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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.398

Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.398

Expression of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1 in human brain tumors and their involvement in glial proliferation in vitro

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.398

An overview of the Notch signalling pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.398

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.398

Insight into the physiological functions of PDGF through genetic studies in mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.398

Microglia promote glioma migration.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.398

Maintenance of retinal stem cells by Abcg2 is regulated by notch signaling.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.398

Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.398

PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Steroid-induced CT changes in patients with recurrent malignant glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

A perivascular niche for brain tumor stem cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.398

Low-grade gliomas: an update on pathology and therapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.398

Inhibition of microglial nitric oxide production by hydrocortisone and glucocorticoid precursors

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.398

Brain tumor treatment increases the number of cancer stem-like cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.398

The brain tumor microenvironment.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.398

Radiation enhances tumor necrosis factor alpha production by murine brain cells.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.398

Endothelial signaling during development

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.398

Neurofibromatosis-1 (Nf1) heterozygous brain microglia elaborate paracrine factors that promote Nf1-deficient astrocyte and glioma growth.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.398

Immune defects observed in patients with primary malignant brain tumors

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.398

Effect of dexamethasone on altered brain vascular permeability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Prolongation of survival following depletion of CD4+CD25+ regulatory T cells in mice with experimental brain tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Malignant astrocytic glioma: genetics, biology, and paths to treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Gene expression profiling reveals cross-talk between melanoma and fibroblasts: implications for host-tumor interactions in metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Growth control of cultured microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Endothelial-pericyte interactions in angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Normal human fibroblasts enable melanoma cells to induce angiogenesis in type I collagen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Neural stem/progenitors and glioma stem-like cells have differential sensitivity to chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Microglia in brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Genetic modeling of gliomas in mice: new tools to tackle old problems

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Microglia as a source and target of cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

MGMT gene silencing and benefit from temozolomide in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Unique gene expression patterns indicate microglial contribution to neural stem cell recovery following irradiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

SDF-1 and CXCR4 are up-regulated by VEGF and contribute to glioma cell invasion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Molecular subclassification of diffuse gliomas: seeing order in the chaos

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Cancer-associated stromal fibroblasts promote pancreatic tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Ionizing radiation induces astrocyte gliosis through microglia activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Molecular pathogenesis of malignant glial tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Preferential migration of regulatory T cells mediated by glioma-secreted chemokines can be blocked with chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Effects of dexamethasone on microglial activation in vivo: selective downregulation of major histocompatibility complex class II expression in regenerating facial nucleus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Blood-neural barrier: intercellular communication at glio-vascular interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Astrocytes in injury states rapidly produce anti-inflammatory factors and attenuate microglial inflammatory responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Expression of TNF-alpha and TGF-beta 1 in the rat brain after a single high-dose irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Treatment of cerebral metastases from breast carcinoma with prednisolone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Cytokine expression in radiation-induced delayed cerebral injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

TNF alpha and IL-1beta mediate intercellular adhesion molecule-1 induction via microglia-astrocyte interaction in CNS radiation injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Endothelial trophic support of neuronal production and recruitment from the adult mammalian subependyma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Effector T-cell infiltration positively impacts survival of glioblastoma patients and is impaired by tumor-derived TGF-β.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

The 2007 WHO classification of tumours of the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Chemoresistance in gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Microglia stimulate the invasiveness of glioma cells by increasing the activity of metalloprotease-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Pathological angiogenesis is reduced by targeting pericytes via the NG2 proteoglycan

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Monocyte chemoattractant protein-1 increases microglial infiltration and aggressiveness of gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Pigment epithelium-derived factor is a niche signal for neural stem cell renewal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Differential gene expression analysis reveals generation of an autocrine loop by a mutant epidermal growth factor receptor in glioma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Glioma cell extracellular matrix metalloproteinase inducer (EMMPRIN) (CD147) stimulates production of membrane-type matrix metalloproteinases and activated gelatinase A in co-cultures with brain-derived fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Extent and patterns of MGMT promoter methylation in glioblastoma- and respective glioblastoma-derived spheres.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Regulation of cell migration and cytokine production by HGF-like protein (HLP) / macrophage stimulating protein (MSP) in primary microglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Primary cultures of microglial cells for testing toxicity of anticancer drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Reduced glioma growth following dexamethasone or anti-angiopoietin 2 treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Glioma-associated endothelial cells are chemoresistant to temozolomide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Glioblastoma stem-like cells give rise to tumour endothelium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Corticosteroid-induced magnetic resonance imaging changes in patients with recurrent malignant glioma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

IL-6 is required for glioma development in a mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Malignant gliomas in adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Glial cell line-derived neurotrophic factor (GDNF) is a proliferation factor for rat C6 glioma cells: evidence from antisense experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Structural alterations of the epidermal growth factor receptor gene in human gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Glioma cancer stem cells induce immunosuppressive macrophages/microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Hypoxia-induced astrocytes promote the migration of neural progenitor cells via vascular endothelial factor, stem cell factor, stromal-derived factor-1alpha and monocyte chemoattractant protein-1 upregulation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

IDH1 and IDH2 mutations in gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

CXCR4 is a major chemokine receptor on glioma cells and mediates their survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Efficacy, safety and patterns of response and recurrence in patients with recurrent high-grade gliomas treated with bevacizumab plus irinotecan.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Transient inflammation in neurogenic regions after irradiation of the developing brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Glial and neuronal cells express functional chemokine receptor CXCR4 and its natural ligand stromal cell-derived factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Exploitation of astrocytes by glioma cells to facilitate invasiveness: a mechanism involving matrix metalloproteinase-2 and the urokinase-type plasminogen activator-plasmin cascade.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

Release of cytokines by brain endothelial cells: A polarized response to lipopolysaccharide

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.398

31 March 2020

Identifiers

DOI

10.1038/ONC.2011.398

1 reference

25 August 2017

1 reference

PubMed ID

21909136