(Q37736255)

22 August 2017

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title

Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma (English)

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22 August 2017

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2

Eric C Holland

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22 August 2017

Jason T Huse

1

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22 August 2017

language of work or name

English

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publication date

1 May 2010

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22 August 2017

published in

Nature Reviews Cancer

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22 August 2017

volume

10

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22 August 2017

issue

5

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22 August 2017

page(s)

319-331

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https://scigraph.springernature.com/pub.10.1038/nrc2818

22 August 2017

exact match

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cites work

The prognostic impact of prior low grade histology in patients with anaplastic gliomas: a case-control study.

1 reference

Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas

21 January 2018

1 reference

"Large cell/anaplastic" medulloblastomas: a Pediatric Oncology Group Study.

21 January 2018

1 reference

Morphophenotypic variation predicts clinical behavior in childhood non-desmoplastic medulloblastomas.

21 January 2018

1 reference

Concurrent inactivation of RB1 and TP53 pathways in anaplastic oligodendrogliomas.

21 January 2018

1 reference

APC mutations in sporadic medulloblastomas

21 January 2018

1 reference

Deletion mapping on chromosome 17p in medulloblastoma

21 January 2018

1 reference

Aggressive medulloblastoma with high-level N-myc amplification.

21 January 2018

1 reference

c-Myc enhances sonic hedgehog-induced medulloblastoma formation from nestin-expressing neural progenitors in mice

21 January 2018

1 reference

Prognostic significance of the c-erbB-2 oncogene product in childhood medulloblastoma

21 January 2018

1 reference

Daoy medulloblastoma cells that express CD133 are radioresistant relative to CD133- cells, and the CD133+ sector is enlarged by hypoxia

21 January 2018

1 reference

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

21 January 2018

1 reference

Modeling Adult Gliomas Using RCAS/t-va Technology

21 January 2018

1 reference

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

21 January 2018

1 reference

Malignant gliomas in adults

31 March 2020

1 reference

Medulloblastoma: signalling a change in treatment

31 March 2020

1 reference

The 2007 WHO classification of tumours of the central nervous system

31 March 2020

1 reference

A case history of glioma progression

31 March 2020

1 reference

Treatment of early childhood medulloblastoma by postoperative chemotherapy alone

31 March 2020

1 reference

Staging, scoring and grading of medulloblastoma. A postoperative prognosis predicting system based on the cases of a single institute.

31 March 2020

1 reference

Stratification of medulloblastoma on the basis of histopathological grading.

31 March 2020

1 reference

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

31 March 2020

1 reference

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome

31 March 2020

1 reference

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin.

31 March 2020

1 reference

Structural alterations of the epidermal growth factor receptor gene in human gliomas

31 March 2020

1 reference

Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas

31 March 2020

1 reference

Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas

31 March 2020

1 reference

Localization of common deletion regions on 1p and 19q in human gliomas and their association with histological subtype

31 March 2020

1 reference

The retinoblastoma gene is involved in malignant progression of astrocytomas

31 March 2020

1 reference

Genome-wide association study identifies five susceptibility loci for glioma

31 March 2020

1 reference

Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility

31 March 2020

1 reference

PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo

31 March 2020

1 reference

mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma

31 March 2020

1 reference

Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model

31 March 2020

1 reference

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

31 March 2020

1 reference

Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation.

31 March 2020

1 reference

Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation

31 March 2020

1 reference

p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

31 March 2020

1 reference

Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma

31 March 2020

1 reference

Platelet-derived growth factor and its receptor expression in human oligodendrogliomas.

31 March 2020

1 reference

Platelet-derived growth factor in human glioma

31 March 2020

1 reference

A human brain tumor-derived PDGFR-alpha deletion mutant is transforming

31 March 2020

1 reference

Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis

31 March 2020

1 reference

Proliferation of human malignant astrocytomas is dependent on Ras activation.

31 March 2020

1 reference

Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas

31 March 2020

1 reference

Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis

31 March 2020

1 reference

High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model.

31 March 2020

1 reference

Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis

31 March 2020

1 reference

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

31 March 2020

1 reference

Pten haploinsufficiency accelerates formation of high-grade astrocytomas

31 March 2020

1 reference

Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model

31 March 2020

1 reference

Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization

31 March 2020

1 reference

Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities.

31 March 2020

1 reference

Array comparative genomic hybridization identifies genetic subgroups in grade 4 human astrocytoma

31 March 2020

1 reference

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

31 March 2020

1 reference

Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma

31 March 2020

1 reference

Clinical evidence of distinct subgroups of astrocytic tumors defined by comparative genomic hybridization.

31 March 2020

1 reference

An integrated genomic analysis of human glioblastoma multiforme

31 March 2020

1 reference

A network model of a cooperative genetic landscape in brain tumors

31 March 2020

1 reference

IDH1 and IDH2 mutations in gliomas

31 March 2020

1 reference

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.

31 March 2020

1 reference

Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas.

31 March 2020

1 reference

Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

31 March 2020

1 reference

Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target

31 March 2020

1 reference

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

31 March 2020

1 reference

Recurring mutations found by sequencing an acute myeloid leukemia genome

31 March 2020

1 reference

The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo

31 March 2020

1 reference

Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship

31 March 2020

1 reference

MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes

31 March 2020

1 reference

MicroRNA involvement in glioblastoma pathogenesis

31 March 2020

1 reference

Unsupervised analysis of transcriptomic profiles reveals six glioma subtypes

31 March 2020

1 reference

Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme

31 March 2020

1 reference

Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis

31 March 2020

1 reference

Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target

31 March 2020

1 reference

Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations

31 March 2020

1 reference

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

31 March 2020

1 reference

The transcriptional network for mesenchymal transformation of brain tumours.

31 March 2020

1 reference

Medulloblastoma: what is the role of molecular genetics?

31 March 2020

1 reference

Mutations in SUFU predispose to medulloblastoma

31 March 2020

1 reference

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

31 March 2020

1 reference

Molecular biology of medulloblastoma therapy

31 March 2020

1 reference

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma

31 March 2020

1 reference

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells

31 March 2020

1 reference

N-myc can substitute for insulin-like growth factor signaling in a mouse model of sonic hedgehog-induced medulloblastoma.

31 March 2020

1 reference

Altered neural cell fates and medulloblastoma in mouse patched mutants

31 March 2020

1 reference

The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas

31 March 2020

1 reference

The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread.

31 March 2020

1 reference

Patched2 modulates tumorigenesis in patched1 heterozygous mice

31 March 2020

1 reference

Apoptosis suppression by somatic cell transfer of Bcl-2 promotes Sonic hedgehog-dependent medulloblastoma formation in mice

31 March 2020

1 reference

High incidence of medulloblastoma following X-ray-irradiation of newborn Ptc1 heterozygous mice

31 March 2020

1 reference

Linking DNA damage to medulloblastoma tumorigenesis in patched heterozygous knockout mice.

31 March 2020

1 reference

Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice

31 March 2020

1 reference

Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells

31 March 2020

1 reference

Nuclear localization and mutation of beta-catenin in medulloblastomas

31 March 2020

1 reference

Medulloblastoma: from molecular pathology to therapy

31 March 2020

1 reference

AXIN1 mutations but not deletions in cerebellar medulloblastomas

31 March 2020

1 reference

Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas

31 March 2020

1 reference

Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors

31 March 2020

1 reference

beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee

31 March 2020

1 reference

c-Myc and beta-catenin cooperate with loss of p53 to generate multiple members of the primitive neuroectodermal tumor family in mice

31 March 2020

1 reference

Structural chromosomal abnormalities in human medulloblastoma

31 March 2020

1 reference

Tumor suppressor genes and medulloblastoma

31 March 2020

1 reference

Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients.

31 March 2020

1 reference

Imbalances of chromosome 17 in medulloblastomas determined by comparative genomic hybridisation and fluorescence in situ hybridisation

31 March 2020

1 reference

Detection of i(17q) chromosome by fluorescent in situ hybridization (FISH) with interphase nuclei in medulloblastoma

31 March 2020

1 reference

Loss of suppressor-of-fused function promotes tumorigenesis.

31 March 2020

1 reference

The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation

31 March 2020

1 reference

miRiad roles for the miR-17-92 cluster in development and disease

31 March 2020

1 reference

Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease

31 March 2020

1 reference

Clinical and molecular stratification of disease risk in medulloblastoma

31 March 2020

1 reference

Medulloblastoma Sensitivity to 17-Allylamino-17-demethoxygeldanamycin Requires MEK/ERK

31 March 2020

1 reference

Novel ERBB4 juxtamembrane splice variants are frequently expressed in childhood medulloblastoma

31 March 2020

1 reference

Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma

31 March 2020

1 reference

Prediction of central nervous system embryonal tumour outcome based on gene expression

31 March 2020

1 reference

Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features

31 March 2020

1 reference

Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations

31 March 2020

1 reference

Stem cells, cancer, and cancer stem cells

31 March 2020

1 reference

Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma

31 March 2020

1 reference

Identification of human brain tumour initiating cells

31 March 2020

1 reference

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

31 March 2020

1 reference

Identification of A2B5+CD133- tumor-initiating cells in adult human gliomas

31 March 2020

1 reference

CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells

31 March 2020

1 reference

How powerful is CD133 as a cancer stem cell marker in brain tumors?

31 March 2020

1 reference

Making a tumour's bed: glioblastoma stem cells and the vascular niche.

31 March 2020

1 reference

Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats

31 March 2020

1 reference

Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia

31 March 2020

1 reference

Brain micro-ecologies: neural stem cell niches in the adult mammalian brain

31 March 2020

1 reference

A perivascular niche for brain tumor stem cells

31 March 2020

1 reference

Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor

31 March 2020

1 reference

Turning cancer stem cells inside out: an exploration of glioma stem cell signaling pathways

31 March 2020

1 reference

Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas

31 March 2020

1 reference

Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells

31 March 2020

1 reference

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

31 March 2020

1 reference

Emerging role of Notch in stem cells and cancer

31 March 2020

1 reference

Notch signaling enhances nestin expression in gliomas

31 March 2020

1 reference

Maintenance of retinal stem cells by Abcg2 is regulated by notch signaling.

31 March 2020

1 reference

Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors

31 March 2020

1 reference

PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells

31 March 2020

1 reference

Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells

31 March 2020

1 reference

PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

31 March 2020

1 reference

Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma

31 March 2020

1 reference

Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses.

31 March 2020

1 reference

New (alternative) temozolomide regimens for the treatment of glioma

31 March 2020

1 reference

Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

31 March 2020

1 reference

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

31 March 2020

1 reference

Genetically engineered mouse models of brain cancer and the promise of preclinical testing

31 March 2020

1 reference

ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice

31 March 2020

1 reference

Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01.

31 March 2020

1 reference

Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastoma multiforme.

31 March 2020

1 reference

Blood-brain barrier and chemotherapeutic treatment of brain tumors

31 March 2020

1 reference

New strategies to deliver anticancer drugs to brain tumors

31 March 2020

1 reference

ERBB2 up-regulates S100A4 and several other prometastatic genes in medulloblastoma.

31 March 2020

1 reference

12 December 2020

The ABCG2 resistance network of glioblastoma

1 reference

12 December 2020

Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice

1 reference

12 December 2020

Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt.

1 reference

12 December 2020

Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2

1 reference

12 December 2020

Genetic aberrations defined by comparative genomic hybridization distinguish long-term from typical survivors of glioblastoma.

1 reference

12 December 2020

Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p

1 reference

12 December 2020

Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model.

1 reference

12 December 2020

Prognostic significance of chromosome 17p deletions in childhood primitive neuroectodermal tumors (medulloblastomas) of the central nervous system.

1 reference

12 December 2020

Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum

1 reference

12 December 2020

Classification of human astrocytic gliomas on the basis of gene expression: a correlated group of genes with angiogenic activity emerges as a strong predictor of subtypes.

1 reference

12 December 2020

1 reference

12 December 2020

Expression of epidermal growth factor receptors in human brain tumors

1 reference

12 December 2020

Large-cell medulloblastomas. A distinct variant with highly aggressive behavior

1 reference

12 December 2020

Sporadic medulloblastomas contain PTCH mutations.

1 reference

12 December 2020

Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus.

1 reference

12 December 2020

Genetic determinants of malignancy in a mouse model for oligodendroglioma

1 reference

12 December 2020

Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas.

1 reference

12 December 2020

MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group

1 reference

12 December 2020

Identification of a cancer stem cell in human brain tumors

1 reference

12 December 2020

Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system

1 reference

12 December 2020

Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene

1 reference

12 December 2020

Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched.

1 reference

12 December 2020

Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.

1 reference

12 December 2020

Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas.

1 reference

12 December 2020

Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma.

1 reference

12 December 2020

A simplified classification of the gliomas.

1 reference

12 December 2020

Sporadic medulloblastomas contain oncogenic beta-catenin mutations.

1 reference

12 December 2020

Gene expression-based classification of malignant gliomas correlates better with survival than histological classification.

1 reference

12 December 2020

The p53 gene and protein in human brain tumors

1 reference

12 December 2020

Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA.

1 reference

12 December 2020

Clonal genomic alterations in glioma malignancy stages.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC2818

1 reference

22 August 2017

1 reference