(Q37439503)

20 August 2017

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title

Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target (English)

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20 August 2017

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Randy L Jensen

1

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20 August 2017

publication date

9 April 2009

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Journal of Neuro-Oncology

20 August 2017

published in

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20 August 2017

volume

92

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20 August 2017

issue

3

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20 August 2017

page(s)

317-335

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https://scigraph.springernature.com/pub.10.1007/s11060-009-9827-2

20 August 2017

exact match

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cites work

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Malignant glioma physiology: cellular response to hypoxia and its role in tumor progression

21 January 2018

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Daoy medulloblastoma cells that express CD133 are radioresistant relative to CD133- cells, and the CD133+ sector is enlarged by hypoxia

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Blood flow and regulation of blood flow in experimental peritumoral edema.

21 January 2018

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Anomalous patterns of nitroimidazole binding adjacent to necrosis in human glioma xenografts: possible role of decreased oxygen consumption

21 January 2018

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Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumors

21 January 2018

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Expression of three viral oncogenes (v-sis, v-myc, v-fos) in primary human brain tumors of neuroectodermal origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11060-009-9827-2

Spatial relationship between hypoxia and the (perfused) vascular network in a human glioma xenograft: a quantitative multi-parameter analysis

21 January 2018

1 reference

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Tumor hypoxia is important in radiotherapy, but how should we measure it?

21 January 2018

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Stimulation of tumour angiogenesis by proximal wounds: spatial and temporal analysis by MRI.

21 January 2018

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Correlation of dynamic contrast-enhanced MR imaging with histologic tumor grade: comparison of macromolecular and small-molecular contrast media

21 January 2018

1 reference

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Prostate cancer tumor grade differentiation with dynamic contrast-enhanced MR imaging in the rat: comparison of macromolecular and small-molecular contrast media--preliminary experience

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11060-009-9827-2

Glial neoplasms: dynamic contrast-enhanced T2*-weighted MR imaging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11060-009-9827-2

Metabolism of human gliomas: assessment with H-1 MR spectroscopy and F-18 fluorodeoxyglucose PET.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11060-009-9827-2

Assessing tumor hypoxia in cervical cancer by positron emission tomography with 60Cu-ATSM: relationship to therapeutic response-a preliminary report

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11060-009-9827-2

Cytosine deaminase/5-fluorocytosine exposure induces bystander and radiosensitization effects in hypoxic glioblastoma cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11060-009-9827-2

Enhancement of gene expression under hypoxic conditions using fragments of the human vascular endothelial growth factor and the erythropoietin genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11060-009-9827-2

Hypoxia in the tumorigenesis of gliomas and as a potential target for therapeutic measures

21 January 2018

1 reference

12 December 2020

Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor

1 reference

12 December 2020

Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy

1 reference

12 December 2020

Cell type-specific, topoisomerase II-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation by NSC 644221.

1 reference

12 December 2020

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

12 December 2020

Noscapine induces apoptosis in human glioma cells by an apoptosis-inducing factor-dependent pathway

1 reference

12 December 2020

Phase I trial of concurrent tirapazamine, cisplatin, and radiotherapy in patients with advanced head and neck cancer

1 reference

12 December 2020

Drug resistance in Chinese hamster ovary cells during recovery from severe hypoxia.

1 reference

12 December 2020

Hypoxia-regulated protein expression, patient characteristics, and preoperative imaging as predictors of survival in adults with glioblastoma multiforme

1 reference

12 December 2020

Mammalian class theta GST and differential susceptibility to carcinogens: a review

1 reference

12 December 2020

Prognostic significance of preoperative MRI scans in glioblastoma multiforme.

1 reference

12 December 2020

Vascular architecture and hypoxic profiles in human head and neck squamous cell carcinomas

1 reference

12 December 2020

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

1 reference

12 December 2020

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

12 December 2020

Molecular basis of the VHL hereditary cancer syndrome

1 reference

12 December 2020

Copper-62-ATSM: a new hypoxia imaging agent with high membrane permeability and low redox potential.

1 reference

12 December 2020

Fibrous sheath of mammalian spermatozoa

1 reference

12 December 2020

Hypoxia-inducible expression of tumor-associated carbonic anhydrases

1 reference

12 December 2020

Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion

1 reference

12 December 2020

Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity

1 reference

12 December 2020

Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

1 reference

12 December 2020

Molecular-targeted antitumor agents. 19. Furospongolide from a marine Lendenfeldia sp. sponge inhibits hypoxia-inducible factor-1 activation in breast tumor cells

1 reference

12 December 2020

Necrosis induction in glioblastoma cells reveals a new "bioswitch" function for the MT1-MMP/G6PT signaling axis in proMMP-2 activation versus cell death decision

1 reference

12 December 2020

Emodin enhances cytotoxicity of chemotherapeutic drugs in prostate cancer cells: the mechanisms involve ROS-mediated suppression of multidrug resistance and hypoxia inducible factor-1.

1 reference

12 December 2020

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

1 reference

12 December 2020

Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer

1 reference

12 December 2020

New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent

1 reference

12 December 2020

MR-derived cerebral blood volume maps: issues regarding histological validation and assessment of tumor angiogenesis.

1 reference

12 December 2020

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.

1 reference

12 December 2020

Mechanisms of chemoresistance to alkylating agents in malignant glioma

1 reference

12 December 2020

Hypoxia-regulated expression of attenuated diphtheria toxin A fused with hypoxia-inducible factor-1alpha oxygen-dependent degradation domain preferentially induces apoptosis of hypoxic cells in solid tumor

1 reference

12 December 2020

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

1 reference

12 December 2020

Pseudoprogression in glioblastoma.

1 reference

12 December 2020

Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling

1 reference

12 December 2020

Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation

1 reference

12 December 2020

Gene profiling during development and after a peripheral nerve traumatism reveals genes specifically induced by injury in dorsal root ganglia

1 reference

12 December 2020

Blood plasmacytoid dendritic cell responses to CpG oligodeoxynucleotides are impaired in human newborns

1 reference

12 December 2020

Functionality of hypoxia-induced BAX expression in a human glioblastoma xenograft model

1 reference

12 December 2020

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

1 reference

12 December 2020

Modulation of detoxification gene expression in human colon HT29 cells by glutathione-S-transferase inhibitors

1 reference

12 December 2020

Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

1 reference

12 December 2020

Development of a hypoxia-responsive vector for tumor-specific gene therapy

1 reference

12 December 2020

Characterization of [18F]fluoroetanidazole, a new radiopharmaceutical for detecting tumor hypoxia.

1 reference

12 December 2020

Advances in radiation therapy for brain tumors

1 reference

12 December 2020

Glioblastoma in adults

1 reference

12 December 2020

Involvement of Hif-1 in desferrioxamine-induced invasion of glioblastoma cells

1 reference

12 December 2020

Picroliv -- a natural product protects cells and regulates the gene expression during hypoxia/reoxygenation.

1 reference

12 December 2020

Distribution of the glucose transporters in human brain tumors

1 reference

12 December 2020

Rapid detection of the hypoxia-regulated CA-IX and NDRG1 gene expression in different glioblastoma cells in vitro.

1 reference

12 December 2020

HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion

1 reference

12 December 2020

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

1 reference

12 December 2020

Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation

1 reference

12 December 2020

Functions of the von Hippel-Lindau tumour suppressor protein

1 reference

12 December 2020

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

1 reference

12 December 2020

An anoxia inducible endonuclease and enhanced DNA breakage as contributors to genomic instability in cancer

1 reference

12 December 2020

An adenoviral vector regulated by hypoxia for the treatment of ischaemic disease and cancer

1 reference

12 December 2020

Tumor uptake of copper-diacetyl-bis(N(4)-methylthiosemicarbazone): effect of changes in tissue oxygenation.

1 reference

12 December 2020

Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis

1 reference

12 December 2020

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

12 December 2020

Hypoxia enhances the replication of oncolytic herpes simplex virus

1 reference

12 December 2020

The role of radio- and chemotherapy in glioblastoma.

1 reference

12 December 2020

Vascular differences detected by MRI for metastatic versus nonmetastatic breast and prostate cancer xenografts.

1 reference

12 December 2020

A novel protein Depp, which is induced by progesterone in human endometrial stromal cells activates Elk-1 transcription factor

1 reference

12 December 2020

Hypoxia-induced BAX overexpression and radiation killing of hypoxic glioblastoma cells

1 reference

12 December 2020

Hypoxia-mediated stimulation of carcinoma cell invasiveness via upregulation of urokinase receptor expression

1 reference

12 December 2020

Regional blood flow in ethylnitrosourea-induced brain tumors.

1 reference

12 December 2020

Neuroradiographic changes following convection-enhanced delivery of the recombinant cytotoxin interleukin 13-PE38QQR for recurrent malignant glioma

1 reference

12 December 2020

Quantifying regional hypoxia in human tumors with positron emission tomography of [18F]fluoromisonidazole: a pretherapy study of 37 patients

1 reference

12 December 2020

Intracranial tumors: response and resistance to therapeutic endeavors, 1970-1980.

1 reference

12 December 2020

Comparisons among pimonidazole binding, oxygen electrode measurements, and radiation response in C3H mouse tumors

1 reference

12 December 2020

Evaluation of malignant glioma patients during the postirradiation period

1 reference

12 December 2020

Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein

1 reference

12 December 2020

Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan

1 reference

12 December 2020

Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer

1 reference

12 December 2020

Signaling cross-talk between hypoxia and glucose via hypoxia-inducible factor 1 and glucose response elements.

1 reference

12 December 2020

Suppression of growth of renal carcinoma cells by the von Hippel-Lindau tumor suppressor gene

1 reference

12 December 2020

Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis

1 reference

12 December 2020

Aldo-keto reductase (AKR) 1C3: role in prostate disease and the development of specific inhibitors

1 reference

12 December 2020

Assessment of hypoxia and perfusion in human brain tumors using PET with 18F-fluoromisonidazole and 15O-H2O.

1 reference

12 December 2020

Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells

1 reference

12 December 2020

Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy

1 reference

12 December 2020

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

1 reference

12 December 2020

Intratumoral oxygen pressure in malignant brain tumor

1 reference

12 December 2020

Early growth response gene-1 regulates hypoxia-induced expression of tissue factor in glioblastoma multiforme through hypoxia-inducible factor-1-independent mechanisms

1 reference

12 December 2020

Imaging of angiogenesis: from microscope to clinic

1 reference

12 December 2020

Assessing tumor angiogenesis using macromolecular MR imaging contrast media.

1 reference

12 December 2020

CHOP is involved in neuronal apoptosis induced by neurotrophic factor deprivation.

1 reference

12 December 2020

Hypoxic Stress Proteins: Survival of the Fittest

1 reference

12 December 2020

Transcriptional response to hypoxia in human tumors

1 reference

12 December 2020

Hypoxia: the tumor's gateway to progression along the angiogenic pathway

1 reference

12 December 2020

Hypoxia-induced resistance to doxorubicin and methotrexate in human melanoma cell lines in vitro.

1 reference

12 December 2020

Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element

1 reference

12 December 2020

Invasion is a genetic program regulated by transcription factors

1 reference

12 December 2020

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1 reference

12 December 2020

Replicative oncolytic adenoviruses in multimodal cancer regimens

1 reference

12 December 2020

Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma

1 reference

12 December 2020

Expression of hypoxia inducible factor-1alpha in tumors of patients with glioblastoma multiforme and transitional meningioma.

1 reference

12 December 2020

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

12 December 2020

ARC-111 inhibits hypoxia-mediated hypoxia-inducible factor-1alpha accumulation.

1 reference

12 December 2020

Localization of the A kinase anchoring protein AKAP79 in the human hippocampus

1 reference

12 December 2020

Loss of PTEN facilitates HIF-1-mediated gene expression

1 reference

12 December 2020

Mitochondrial reactive oxygen species control the transcription factor CHOP-10/GADD153 and adipocyte differentiation: a mechanism for hypoxia-dependent effect

1 reference

12 December 2020

Von Hippel-Lindau syndrome. A pleomorphic condition

1 reference

12 December 2020

Exposure to hypoxia, glucose starvation and acidosis: effect on invasive capacity of murine tumor cells and correlation with cathepsin (L + B) secretion

1 reference

12 December 2020

Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype

1 reference

12 December 2020

Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway

1 reference

12 December 2020

Loss of VHL confers hypoxia-inducible factor (HIF)-dependent resistance to vesicular stomatitis virus: role of HIF in antiviral response

1 reference

12 December 2020

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1 reference

12 December 2020

Modes of resistance to anti-angiogenic therapy

1 reference

12 December 2020

The evolution of chemoradiation for glioblastoma: a modern success story

1 reference

12 December 2020

Insulin-like growth factor binding proteins: new proteins, new functions

1 reference

12 December 2020

A tiger behind many doors: multiple genetic pathways to malignant glioma

1 reference

12 December 2020

MGMT promoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patients

1 reference

12 December 2020

Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene

1 reference

12 December 2020

Ibuprofen: effect on inducible nitric oxide synthase.

1 reference

12 December 2020

Relation of vascular endothelial growth factor production to expression and regulation of hypoxia-inducible factor-1 alpha and hypoxia-inducible factor-2 alpha in human bladder tumors and cell lines

1 reference

12 December 2020

Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2.

1 reference

12 December 2020

Silencing of hypoxia inducible factor-1alpha by RNA interference attenuates human glioma cell growth in vivo.

1 reference

12 December 2020

Expression of facilitative glucose transporter isoforms in human brain tumors

1 reference

12 December 2020

Necrosis and glioblastoma: a friend or a foe? A review and a hypothesis

1 reference

12 December 2020

Tumor tissue oxygenation as evaluated by computerized-pO2-histography

1 reference

12 December 2020

A dominant-negative isoform lacking exons 11 and 12 of the human hypoxia-inducible factor-1alpha gene

1 reference

12 December 2020

Differential expression in glioblastoma multiforme and cerebral hemangioblastoma of cytoplasmic proteins that bind two different domains within the 3'-untranslated region of the human glucose transporter 1 (GLUT1) messenger RNA.

1 reference

12 December 2020

Expression of hypoxia-inducible factor 1alpha in tumours of patients with glioblastoma

1 reference

12 December 2020

Angiogenesis: how a tumor adapts to hypoxia

1 reference

12 December 2020

Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors

1 reference

12 December 2020

Hypoxia causes downregulation of mismatch repair system and genomic instability in stem cells

1 reference

12 December 2020

GLUT-1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: relationship to pimonidazole binding.

1 reference

12 December 2020

Regional comparison of tumor vascularity and permeability parameters measured by albumin-Gd-DTPA and Gd-DTPA.

1 reference

12 December 2020

Proto-oncogene analyses in brain tumors

1 reference

12 December 2020

Identification of the von Hippel-Lindau disease tumor suppressor gene

1 reference

12 December 2020

PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma.

1 reference

12 December 2020

Safety and feasibility of convection-enhanced delivery of Cotara for the treatment of malignant glioma: initial experience in 51 patients.

1 reference

12 December 2020

Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population

1 reference

12 December 2020

Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP

1 reference

12 December 2020

Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes.

1 reference

12 December 2020

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

1 reference

12 December 2020

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

1 reference

12 December 2020

Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix

1 reference

12 December 2020

Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7

1 reference

12 December 2020

Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration

1 reference

12 December 2020

Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo.

1 reference

12 December 2020

Imaging hypoxia after oxygenation-modification: comparing [18F]FMISO autoradiography with pimonidazole immunohistochemistry in human xenograft tumors.

1 reference

12 December 2020

Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases

1 reference

12 December 2020

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

1 reference

12 December 2020

Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide

1 reference

12 December 2020

Contemporary approaches to the treatment of malignant gliomas with radiation therapy.

1 reference

12 December 2020

Oncogenes as inducers of tumor angiogenesis

1 reference

12 December 2020

Polarographic measurements of oxygen tension in human glioma and surrounding peritumoural brain tissue.

1 reference

12 December 2020

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

1 reference

12 December 2020

Hypoxia in human gliomas: demonstration by PET with fluorine-18-fluoromisonidazole

1 reference

12 December 2020

Evaluation of 64Cu-ATSM in vitro and in vivo in a hypoxic tumor model

1 reference

12 December 2020

Gene expression of GLUT3 and GLUT1 glucose transporters in human brain tumors.

1 reference

12 December 2020

The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis

1 reference

12 December 2020

Identification of necrosis-associated genes in glioblastoma by cDNA microarray analysis

1 reference

12 December 2020

Tumor hypoxia and gene expression--implications for malignant progression and therapy

1 reference

12 December 2020

Killing of brain tumor cells by hypoxia-responsive element mediated expression of BAX

1 reference

12 December 2020

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

12 December 2020

Hypoxia can induce c-Met expression in glioma cells and enhance SF/HGF-induced cell migration

1 reference

12 December 2020

Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts

1 reference

12 December 2020

Hypoxia-selective targeting by the bioreductive prodrug AQ4N in patients with solid tumors: results of a phase I study

1 reference

12 December 2020

Physiologic characterisation of glioblastoma multiforme using MRI-based hypoxia mapping, chemical shift imaging, perfusion and diffusion maps.

1 reference

12 December 2020

Irradiation and hypoxia promote homing of haematopoietic progenitor cells towards gliomas by TGF-beta-dependent HIF-1alpha-mediated induction of CXCL12.

1 reference

12 December 2020

The relationship between genetic aberrations as detected by comparative genomic hybridization and vascularization in glioblastoma xenografts.

1 reference

12 December 2020

'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis

1 reference

12 December 2020

Somatic mutations of the von Hippel-Lindau tumor suppressor gene and loss of heterozygosity on chromosome 3p in human glial tumors.

1 reference

12 December 2020

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

12 December 2020

Anoxia-inducible endonuclease activity as a potential basis of the genomic instability of cancer cells

1 reference

12 December 2020

Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome

1 reference

12 December 2020

Decreased expression of IGF-II and its binding protein, IGF-binding protein-2, in genital skin fibroblasts of patients with complete androgen insensitivity syndrome compared with normally virilized males

1 reference

12 December 2020

Control of cyclin G2 mRNA expression by forkhead transcription factors: novel mechanism for cell cycle control by phosphoinositide 3-kinase and forkhead

1 reference

12 December 2020

Increased expression of type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma

1 reference

12 December 2020

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT

1 reference

12 December 2020

Posttherapeutic intraaxial brain tumor: the value of perfusion-sensitive contrast-enhanced MR imaging for differentiating tumor recurrence from nonneoplastic contrast-enhancing tissue.

1 reference

12 December 2020

Determinants of tumor blood flow: a review

1 reference

12 December 2020

The pro-cell death Bcl-2 family member, BNIP3, is localized to the nucleus of human glial cells: Implications for glioblastoma multiforme tumor cell survival under hypoxia

1 reference

12 December 2020

Neurobeachin is essential for neuromuscular synaptic transmission.

1 reference

12 December 2020

Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.

1 reference

12 December 2020

Isolation of arterial-specific genes by subtractive hybridization reveals molecular heterogeneity among arterial endothelial cells

1 reference

12 December 2020

Role of radionuclide imaging in trials of antiangiogenic therapy

1 reference

12 December 2020

Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells

1 reference

12 December 2020

Regional measurements of blood flow in experimental RG-2 rat gliomas.

1 reference

12 December 2020

Anti-angiogenic agents for the treatment of brain tumors

1 reference

12 December 2020

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

1 reference

12 December 2020

Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer

1 reference

12 December 2020

In vivo prediction of vascular susceptibility to vascular susceptibility endothelial growth factor withdrawal: magnetic resonance imaging of C6 rat glioma in nude mice.

1 reference

12 December 2020

Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia

1 reference

12 December 2020

Hypoxia- and vascular endothelial growth factor-induced stromal cell-derived factor-1alpha/CXCR4 expression in glioblastomas: one plausible explanation of Scherer's structures.

1 reference

12 December 2020

Tumour oxygenation assessed by 18F-fluoromisonidazole PET and polarographic needle electrodes in human soft tissue tumours

1 reference

12 December 2020

Determining hypoxic fraction in a rat glioma by uptake of radiolabeled fluoromisonidazole.

1 reference

12 December 2020

Differential regulation of VEGF, HIF1alpha and angiopoietin-1, -2 and -4 by hypoxia and ionizing radiation in human glioblastoma

1 reference

12 December 2020

A hypoxia-regulated adeno-associated virus vector for cancer-specific gene therapy

1 reference

12 December 2020

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

1 reference

12 December 2020

Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients

1 reference

12 December 2020

Identification of hypoxia-induced genes in a malignant glioma cell line (U-251) by cDNA microarray analysis.

1 reference

12 December 2020

Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state

1 reference

12 December 2020

Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer

1 reference

12 December 2020

Tumor microvascular characterization using ultrasmall superparamagnetic iron oxide particles (USPIO) in an experimental breast cancer model

1 reference

12 December 2020

In vitro angiogenesis by human umbilical vein endothelial cells (HUVEC) induced by three-dimensional co-culture with glioblastoma cells.

1 reference

12 December 2020

A clinical study of hypoxia and metallothionein protein expression in squamous cell carcinomas

1 reference

12 December 2020

Generation of bidirectional hypoxia/HIF-responsive expression vectors to target gene expression to hypoxic cells

1 reference

12 December 2020

Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer

1 reference

12 December 2020

Hypoxia inhibits paclitaxel-induced apoptosis through adenosine-mediated phosphorylation of bad in glioblastoma cells

1 reference

12 December 2020

The VHL tumour-suppressor gene paradigm

1 reference

12 December 2020

The A-kinase anchor protein MAP2B and cAMP-dependent protein kinase are associated with class C L-type calcium channels in neurons

1 reference

12 December 2020

Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions

1 reference

12 December 2020

Tumor hypoxia in pelvic recurrences of cervical cancer.

1 reference

12 December 2020

Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.

1 reference

12 December 2020

Incidence of early pseudo-progression in a cohort of malignant glioma patients treated with chemoirradiation with temozolomide

1 reference

12 December 2020

Regional hypoxia in glioblastoma multiforme quantified with [18F]fluoromisonidazole positron emission tomography before radiotherapy: correlation with time to progression and survival

1 reference

12 December 2020

The response of human tumors to carbogen breathing, monitored by gradient-recalled echo magnetic resonance imaging

1 reference

12 December 2020

Hypoxia-inducible transgene expression in differentiated human NT2N neurons--a cell culture model for gene therapy of postischemic neuronal loss.

1 reference

12 December 2020

Tumor hypoxia: Impact on gene amplification in glioblastoma.

1 reference

12 December 2020

Establishing a link between oncogenes and tumor angiogenesis

1 reference

12 December 2020

Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway

1 reference

12 December 2020

Carbonic anhydrase 9 as an endogenous marker for hypoxic cells in cervical cancer.

1 reference

12 December 2020

Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma

1 reference

12 December 2020

A novel hypoxia-inducible factor (HIF) activated oncolytic adenovirus for cancer therapy.

1 reference

12 December 2020

Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells

1 reference

12 December 2020

SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells

1 reference

12 December 2020

Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis

1 reference

12 December 2020

Characterization of physiologically regulated vectors for the treatment of ischemic disease

1 reference

12 December 2020

Genetic modulation of hypoxia induced gene expression and angiogenesis: relevance to brain tumors

1 reference

12 December 2020

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

1 reference

12 December 2020

Localised proton spectroscopy and spectroscopic imaging in cerebral gliomas, with comparison to positron emission tomography

1 reference

12 December 2020

Glucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma?

1 reference

12 December 2020

Essential roles of IGFBP-3 and IGFBP-rP1 in breast cancer

1 reference

12 December 2020

Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression

1 reference

12 December 2020

Characterisation of human cyclin G1 and G2: DNA damage inducible genes

1 reference

12 December 2020

Expression of hypoxia-inducible factor-1alpha (HIF-1alpha) in pituitary tumours

1 reference

12 December 2020

A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth

1 reference

12 December 2020

Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization

1 reference

12 December 2020

Hypoxia imaging in brain tumors

1 reference

12 December 2020

Evaluation of hypoxia-inducible factor-1alpha (HIF-1alpha) as an intrinsic marker of tumor hypoxia in U87 MG human glioblastoma: in vitro and xenograft studies

1 reference

12 December 2020

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

1 reference

12 December 2020

Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations

1 reference

12 December 2020

Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas

1 reference

12 December 2020

Regulation of angiogenesis by hypoxia: role of the HIF system

1 reference

12 December 2020

Imaging and quantitation of the hypoxic cell fraction of viable tumor in an animal model of intracerebral high grade glioma using [18F]fluoromisonidazole (FMISO).

1 reference

12 December 2020

Importance of hypoxia in the biology and treatment of brain tumors

1 reference

12 December 2020

Expression patterns of the hypoxia-related genes osteopontin, CA9, erythropoietin, VEGF and HIF-1alpha in human glioma in vitro and in vivo

1 reference

12 December 2020

Distribution of regulatory subunits of protein kinase A and A kinase anchor proteins (AKAP 95, 150) in rat pinealocytes.

1 reference

12 December 2020

Retention mechanism of hypoxia selective nuclear imaging/radiotherapeutic agent cu-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) in tumor cells.

1 reference

12 December 2020

Hypoxia-inducible factor-1alpha is an intrinsic marker for hypoxia in cervical cancer xenografts.

1 reference

12 December 2020

Glioma cells suppress hypoxia-induced endothelial cell apoptosis and promote the angiogenic process

1 reference

12 December 2020

Novel promoter polymorphism in insulin-like growth factor-binding protein-3: correlation with serum levels and interaction with known regulators

1 reference

12 December 2020

Use of molecular biomarkers for predicting the response to radiotherapy with or without chemotherapy.

1 reference

12 December 2020

Hypoxia up-regulates telomerase activity via mitogen-activated protein kinase signaling in human solid tumor cells.

1 reference

12 December 2020

Signal transduction to hypoxia-inducible factor 1

1 reference

12 December 2020

High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers

1 reference

12 December 2020

Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells

1 reference

12 December 2020

Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix

1 reference

12 December 2020

Imaging tumor hypoxia and tumor perfusion.

1 reference

12 December 2020

Genotype-phenotype correlation in von Hippel-Lindau syndrome

1 reference

12 December 2020

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

12 December 2020

Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion

1 reference

12 December 2020

A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival

1 reference

12 December 2020

Vascular microenvironment in gliomas

1 reference

12 December 2020

Development of a hypoxia-inducible cytosine deaminase expression vector for gene-directed prodrug cancer therapy.

1 reference

12 December 2020

10.1007/S11060-009-9827-2

Identifiers

DOI

1 reference

20 August 2017

1 reference