(Q44426540)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12726862%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

title

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12726862%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference

Paraskevi Giannakakou

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12726862%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Daniel Escuin

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12726862%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

author name string

Nicola J Mabjeesh

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12726862%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Theresa M LaVallee

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12726862%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Victor S Pribluda

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12726862%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Glenn M Swartz

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12726862%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Michelle S Johnson

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12726862%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Margaret T Willard

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12726862%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Hua Zhong

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12726862%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Jonathan W Simons

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12726862%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

publication date

1 April 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12726862%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12726862%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

volume

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12726862%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12726862%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

page(s)

363-375

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12726862%20AND%20SRC:MED&resulttype=core&format=json

2-Methoxyestradiol Arrests Cells in Mitosis without Depolymerizing Tubulin

3 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

2-Methoxyestradiol overcomes drug resistance in multiple myeloma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Synthesis of analogs of 2-methoxyestradiol with enhanced inhibitory effects on tubulin polymerization and cancer cell growth.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Angiogenesis-dependent diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

SNARE hypothesis 2000

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Resolution of subcellular detail in thick tissue sections: immunohistochemical preparation and fluorescence confocal microscopy

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Hypoxia--a key regulatory factor in tumour growth

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Clinical application of antiangiogenic therapy: microvessel density, what it does and doesn't tell us.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

SOD1 down-regulates NF-kappaB and c-Myc expression in mice after transient focal cerebral ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

2-methoxyestradiol does not inhibit superoxide dismutase

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

2-Methoxyestradiol, a promising anticancer agent

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Oxygen sensors and angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Generation of bidirectional hypoxia/HIF-responsive expression vectors to target gene expression to hypoxic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

2-Methoxyestradiol: an endogenous antiangiogenic and antiproliferative drug candidate

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Inhibition of tumor necrosis factor alpha-stimulated aromatase activity by microtubule-stabilizing agents, paclitaxel and 2-methoxyestradiol

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

New insights into an enigmatic tumour suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Mechanisms of angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

The mammalian metabolite, 2-methoxyestradiol, affects P53 levels and apoptosis induction in transformed cells but not in normal cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Signal transduction to hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900077-1

7 January 2021

10.1016/S1535-6108(03)00077-1

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12726862%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference