(Q35721964)

9 August 2017

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title

Medulloblastoma: signalling a change in treatment (English)

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9 August 2017

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Richard J Gilbertson

1

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9 August 2017

1 April 2004

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Lancet Oncology Commission

9 August 2017

1 reference

9 August 2017

5

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9 August 2017

4

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9 August 2017

209-218

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Cancer surveillance series [corrected]: brain and other central nervous system cancers: recent trends in incidence and mortality.

9 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Patterns of intellectual development among survivors of pediatric medulloblastoma: a longitudinal analysis.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Radiotherapy for medulloblastoma in children: a perspective on current international clinical research efforts

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors: Childhood Cancer Survivor Study.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Intellectual outcome after reduced-dose radiation therapy plus adjuvant chemotherapy for medulloblastoma: a Children's Cancer Group study

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

The WHO classification of tumors of the nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Classifying the medulloblastoma: insights from morphology and molecular genetics

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Histopathologic grading of medulloblastomas: a Pediatric Oncology Group study

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Postoperative neoadjuvant chemotherapy before radiotherapy as compared to immediate radiotherapy followed by maintenance chemotherapy in the treatment of medulloblastoma in childhood: results of the German prospective randomized trial HIT '91.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Overview of the treatment of infant central nervous system tumors: medulloblastoma as a model

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Medulloblastomas with systemic metastases: evaluation of tumor histopathology and clinical behavior in 23 patients

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Results of a randomized study of preradiation chemotherapy versus radiotherapy alone for nonmetastatic medulloblastoma: The International Society of Paediatric Oncology/United Kingdom Children's Cancer Study Group PNET-3 Study

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Treatment of children with medulloblastomas with reduced-dose craniospinal radiation therapy and adjuvant chemotherapy: A Children's Cancer Group Study.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Feasibility of four consecutive high-dose chemotherapy cycles with stem-cell rescue for patients with newly diagnosed medulloblastoma or supratentorial primitive neuroectodermal tumor after craniospinal radiotherapy: results of a collaborative study

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Low-stage medulloblastoma: final analysis of trial comparing standard-dose with reduced-dose neuraxis irradiation.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

What's new in neuro-oncology? Recent advances in medulloblastoma

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Outcome for children with medulloblastoma treated with radiation and cisplatin, CCNU, and vincristine chemotherapy.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

The ins and outs of APC and beta-catenin nuclear transport

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

APC mutations in sporadic medulloblastomas

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Nuclear localization and mutation of beta-catenin in medulloblastomas

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

AXIN1 mutations but not deletions in cerebellar medulloblastomas.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Role of Wnt pathway in medulloblastoma oncogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

The molecular basis of Turcot's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

The Hedgehog and Wnt signalling pathways in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Hedgehog-Gli signalling and the growth of the brain.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Developmental roles and clinical significance of hedgehog signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Gli and hedgehog in cancer: tumours, embryos and stem cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Patched acts catalytically to suppress the activity of Smoothened

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Mutations in SUFU predispose to medulloblastoma

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Medulloblastoma growth inhibition by hedgehog pathway blockade

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Altered neural cell fates and medulloblastoma in mouse patched mutants

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Untangling the ErbB signalling network

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastomas

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Clinical and molecular stratification of disease risk in medulloblastoma

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Medulloblastoma Sensitivity to 17-Allylamino-17-demethoxygeldanamycin Requires MEK/ERK

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53(-/-) mice

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-alpha-stimulated STAT2-independent production of IFN-gamma in the brain

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Prediction of central nervous system embryonal tumour outcome based on gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

PDGFRB is overexpressed in metastatic medulloblastoma

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

Suppressor of fused negatively regulates beta-catenin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2804%2901424-X

7 January 2021

10.1016/S1470-2045(04)01424-X

Identifiers

DOI

1 reference

9 August 2017

1 reference

PubMed ID

15050952