(Q37932009)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21916843%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

review article

1 reference

title

MeCP2 and Rett syndrome: reversibility and potential avenues for therapy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21916843%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

0 references

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21916843%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

author name string

Kamal K E Gadalla

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21916843%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Stuart R Cobb

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21916843%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

language of work or name

English

0 references

publication date

1 October 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21916843%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21916843%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

volume

439

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21916843%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21916843%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

page(s)

1-14

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21916843%20AND%20SRC:MED&resulttype=core&format=json

A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome: report of 35 cases

12 February 2020

cites work

1 reference

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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

21 January 2018

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Rett syndrome in Australia: a review of the epidemiology.

21 January 2018

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Rett syndrome: revised diagnostic criteria and nomenclature

21 January 2018

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Parental origin of de novo MECP2 mutations in Rett syndrome

21 January 2018

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Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized

21 January 2018

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MeCP2 dysfunction in Rett syndrome and related disorders

21 January 2018

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Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA

21 January 2018

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Genomic DNA methylation: the mark and its mediators

21 January 2018

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Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation

21 January 2018

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Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation

21 January 2018

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Quantitative localization of heterogeneous methyl-CpG-binding protein 2 (MeCP2) expression phenotypes in normal and Rett syndrome brain by laser scanning cytometry

21 January 2018

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Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

21 January 2018

1 reference

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MeCP2 binding to DNA depends upon hydration at methyl-CpG

21 January 2018

1 reference

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Biophysical analysis and small-angle X-ray scattering-derived structures of MeCP2-nucleosome complexes

21 January 2018

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MeCP2, a key contributor to neurological disease, activates and represses transcription

21 January 2018

1 reference

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Multiple modes of interaction between the methylated DNA binding protein MeCP2 and chromatin.

21 January 2018

1 reference

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Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2.

21 January 2018

1 reference

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A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing

21 January 2018

1 reference

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Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state.

21 January 2018

1 reference

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Rett syndrome: a prototypical neurodevelopmental disorder

21 January 2018

1 reference

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Reversal of neurological defects in a mouse model of Rett syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Behavioral and anatomical abnormalities in Mecp2 mutant mice: a model for Rett syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

MeCP2 functions largely cell-autonomously, but also non-cell-autonomously, in neuronal maturation and dendritic arborization of cortical pyramidal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

MeCP2 deficiency disrupts axonal guidance, fasciculation, and targeting by altering Semaphorin 3F function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Exogenous brain-derived neurotrophic factor rescues synaptic dysfunction in Mecp2-null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

MeCP2-dependent transcriptional repression regulates excitatory neurotransmission.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Synaptic plasticity deficits in an experimental model of rett syndrome: long-term potentiation saturation and its pharmacological reversal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

A mouse model of Rubinstein-Taybi syndrome: defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Correction of fragile X syndrome in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Reversing neurodevelopmental disorders in adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

MeCP2 mutation causes distinguishable phases of acute and chronic defects in synaptogenesis and maintenance, respectively

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

A methyl-CpG-binding protein 2-enhanced green fluorescent protein reporter mouse model provides a new tool for studying the neuronal basis of Rett syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

The story of Rett syndrome: from clinic to neurobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Adult neural function requires MeCP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Cell-specific expression of wild-type MeCP2 in mouse models of Rett syndrome yields insight about pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Targeted delivery of an Mecp2 transgene to forebrain neurons improves the behavior of female Mecp2-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

A new Rett syndrome family consistent with X-linked inheritance expands the X chromosome exclusion map.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Segregation of a totally skewed pattern of X chromosome inactivation in four familial cases of Rett syndrome without MECP2 mutation: implications for the disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Correlation between clinical severity in patients with Rett syndrome with a p.R168X or p.T158M MECP2 mutation, and the direction and degree of skewing of X-chromosome inactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Balanced X chromosome inactivation patterns in the Rett syndrome brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

X-chromosome inactivation patterns are unbalanced and affect the phenotypic outcome in a mouse model of rett syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Age-dependent expression of MeCP2 in a heterozygous mosaic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

MECP2 isoform-specific vectors with regulated expression for Rett syndrome gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Recurrent infections, hypotonia, and mental retardation caused by duplication of MECP2 and adjacent region in Xq28.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Submicroscopic duplication in Xq28 causes increased expression of the MECP2 gene in a boy with severe mental retardation and features of Rett syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in males

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Mild overexpression of MeCP2 causes a progressive neurological disorder in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Lentiviral-mediated gene therapy for murine mucopolysaccharidosis type IIIA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Phase I trial of intramuscular injection of a recombinant adeno-associated virus alpha 1-antitrypsin (rAAV2-CB-hAAT) gene vector to AAT-deficient adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Survival advantage of neonatal CNS gene transfer for late infantile neuronal ceroid lipofuscinosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Modulation of metabolic brain networks after subthalamic gene therapy for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Systemic delivery of scAAV9 expressing SMN prolongs survival in a model of spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Regional intravascular delivery of AAV-2-F.IX to skeletal muscle achieves long-term correction of hemophilia B in a large animal model

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Multiyear therapeutic benefit of AAV serotypes 2, 6, and 8 delivering factor VIII to hemophilia A mice and dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Alterations of cortical and hippocampal EEG activity in MeCP2-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Epilepsy in Rett syndrome: clinical and genetic features.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

The MeCP2-null mouse hippocampus displays altered basal inhibitory rhythms and is prone to hyperexcitability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Brain-derived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Signaling by insulin-like growth factor 1 in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Methyl CpG-binding protein 2 (a mutation of which causes Rett syndrome) directly regulates insulin-like growth factor binding protein 3 in mouse and human brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Rett syndrome: biogenic amines and metabolites in postmortem brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Mecp2 deficiency disrupts norepinephrine and respiratory systems in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Tyrosine hydroxylase deficit in the chemoafferent and the sympathoadrenergic pathways of the Mecp2 deficient mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Pharmacological treatment of Rett syndrome improves breathing and survival in a mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Oral treatment with desipramine improves breathing and life span in Rett syndrome mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Choline acetyltransferase activity and vesamicol binding in Rett syndrome and in rats with nucleus basalis lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Postnatal dietary choline supplementation alters behavior in a mouse model of Rett syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Diminished prevalence but preserved synaptic distribution of N-methyl-D-aspartate receptor subunits in the methyl CpG binding protein 2(MeCP2)-null mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Memantine restores long term potentiation impaired by tonic N-methyl-D-aspartate (NMDA) receptor activation following reduction of Mg2+ in hippocampal slices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

MeCP2 is required for normal development of GABAergic circuits in the thalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

The benzodiazepine Midazolam mitigates the breathing defects of Mecp2-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Correction of respiratory disorders in a mouse model of Rett syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Aminoglycoside suppression at UAG, UAA and UGA codons in Escherichia coli and human tissue culture cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Aminoglycoside antibiotics mediate context-dependent suppression of termination codons in a mammalian translation system

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Correction of genetic disease by making sense from nonsense

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Suppression of a CFTR premature stop mutation in a bronchial epithelial cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Suppression of nonsense mutations in Rett syndrome by aminoglycoside antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

PTC124 targets genetic disorders caused by nonsense mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Management of young children with Rett disorder in the controlled multi-sensory (Snoezelen) environment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Environmental enrichment slows disease progression in R6/2 Huntington's disease mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Enriched environments, experience-dependent plasticity and disorders of the nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Environmental enrichment ameliorates a motor coordination deficit in a mouse model of Rett syndrome--Mecp2 gene dosage effects and BDNF expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Environmental enrichment alters locomotor behaviour and ventricular volume in Mecp2 1lox mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Early environmental enrichment moderates the behavioral and synaptic phenotype of MeCP2 null mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Effects of environmental enrichment on gene expression in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

Global changes in the hippocampal proteome following exposure to an enriched environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

MeCP2-mediated transcription repression in the basolateral amygdala may underlie heightened anxiety in a mouse model of Rett syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110648

21 January 2018

Identifiers

DOI

10.1042/BJ20110648

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21916843%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference