(Q37932556)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21919804%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

review article

1 reference

title

Pharmacogenetics of genes across the doxorubicin pathway (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21919804%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21919804%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Alan V. Boddy

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21919804%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

author name string

David Jamieson

series ordinal

1

1 reference

25 August 2017

Alan V Boddy

series ordinal

2

1 reference

25 August 2017

language of work or name

English

0 references

publication date

1 October 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21919804%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Drug Metabolism & Toxicology

12 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21919804%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21919804%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21919804%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

page(s)

1201-1210

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21919804%20AND%20SRC:MED&resulttype=core&format=json

Mutations of human topoisomerase II alpha affecting multidrug resistance and sensitivity.

12 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Brain bilirubin content is increased in P-glycoprotein-deficient transgenic null mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

MDR1-deficient genotype in Collie dogs hypersensitive to the P-glycoprotein substrate ivermectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Phase I trial of doxorubicin with cyclosporine as a modulator of multidrug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Modulation of multidrug-resistant multiple myeloma by cyclosporin. The Leukaemia Group of the EORTC and the HOVON

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Cyclosporin A combined with vincristine, doxorubicin and dexamethasone (VAD) compared with VAD alone in patients with advanced refractory multiple myeloma: an EORTC-HOVON randomized phase III study (06914).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

MDR1 polymorphism influences the outcome of multiple myeloma patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Function-altering SNPs in the human multidrug transporter gene ABCB1 identified using a Saccharomyces-based assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

A "silent" polymorphism in the MDR1 gene changes substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Substrate-dependent effects of human ABCB1 coding polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Single nucleotide polymorphisms of ABCB1 (MDR1) gene and distinct haplotype profile in a West Black African population

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Quantitative structure--activity relationship analysis and molecular dynamics simulation to functionally validate nonsynonymous polymorphisms of human ABC transporter ABCB1 (P-glycoprotein/MDR1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Functional characterization of coding polymorphisms in the human MDR1 gene using a vaccinia virus expression system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Polymorphisms in the multiple drug resistance protein 1 and in P-glycoprotein 1 are associated with time to event outcomes in patients with advanced multiple myeloma treated with bortezomib and pegylated liposomal doxorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

A multidrug resistance transporter from human MCF-7 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Single nucleotide polymorphisms result in impaired membrane localization and reduced atpase activity in multidrug transporter ABCG2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Induction of MRP5 and SMRP mRNA by adriamycin exposure and its overexpression in human lung cancer cells resistant to adriamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

A distinct "side population" of cells with high drug efflux capacity in human tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Akt signaling regulates side population cell phenotype via Bcrp1 translocation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Characterization of the organic cation transporter SLC22A16: a doxorubicin importer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Adriamycin-induced oxidative mitochondrial cardiotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Naturally occurring variants of human CBR3 alter anthracycline in vitro metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Naturally Occurring Variants of Human Aldo-Keto Reductases with Reduced In Vitro Metabolism of Daunorubicin and Doxorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Two nonsynonymous single nucleotide polymorphisms of human carbonyl reductase 1 demonstrate reduced in vitro metabolism of daunorubicin and doxorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Pharmacogenetics of human carbonyl reductase 1 (CBR1) in livers from black and white donors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Genotype of human carbonyl reductase CBR3 correlates with doxorubicin disposition and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Nitric oxide synthase variants and disease-free survival among treated and untreated breast cancer patients in a Southwest Oncology Group clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Topo2α protein expression predicts response to anthracycline combination neo-adjuvant chemotherapy in locally advanced primary breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Association between HER2, TOP2A, and response to anthracycline-based preoperative chemotherapy in high-risk primary breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Enforced cytokinesis without complete nuclear division in embryonic cells depleting the activity of DNA topoisomerase IIalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Differential formation of hydroxyl radicals by adriamycin in sensitive and resistant MCF-7 human breast tumor cells: implications for the mechanism of action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Gp91phox-containing NAD(P)H oxidase increases superoxide formation by doxorubicin and NADPH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

Analysis of the host pharmacogenetic background for prediction of outcome and toxicity in diffuse large B-cell lymphoma treated with R-CHOP21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

A functional polymorphism in the NAD(P)H oxidase subunit CYBA is related to gene expression, enzyme activity, and outcome in non-Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

A mitochondrial target sequence polymorphism in manganese superoxide dismutase predicts inferior survival in breast cancer patients treated with cyclophosphamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

ABCB1 and GST polymorphisms associated with TP53 status in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

The GST deletions and NQO1*2 polymorphism confers interindividual variability of response to treatment in patients with acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2011.610180

10.1517/17425255.2011.610180

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21919804%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference