(Q37942753)

25 August 2017

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title

Gene therapy for retinal ganglion cell neuroprotection in glaucoma (English)

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25 August 2017

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retinal ganglion cell

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A M Wilson

1

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PubMed ID

21975466

25 August 2017

A Di Polo

series ordinal

2

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25 August 2017

6 October 2011

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25 August 2017

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25 August 2017

19

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25 August 2017

2

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25 August 2017

127-136

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https://scigraph.springernature.com/pub.10.1038/gt.2011.142

25 August 2017

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cites work

The number of people with glaucoma worldwide in 2010 and 2020

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Prevalence of mutations in TIGR/Myocilin in patients with adult and juvenile primary open-angle glaucoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Age-dependent prevalence of mutations at the GLC1A locus in primary open-angle glaucoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Glaucoma: genes, phenotypes, and new directions for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Gene therapy targeting glaucoma: where are we?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Intravitreal injection of adeno-associated viral vectors results in the transduction of different types of retinal neurons in neonatal and adult rats: a comparison with lentiviral vectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Adeno-associated virus gene transfer to mouse retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Gene transfer into the mouse retina mediated by an adeno-associated viral vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Stable transgene expression in rod photoreceptors after recombinant adeno-associated virus-mediated gene transfer to monkey retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Cellular tropism and transduction properties of seven adeno-associated viral vector serotypes in adult retina after intravitreal injection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Gene delivery to the eye using adeno-associated viral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

In vivo gene regulation using tetracycline-regulatable systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Detection of intact rAAV particles up to 6 years after successful gene transfer in the retina of dogs and primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Efficient in vivo gene expression by trans-splicing adeno-associated viral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Immune responses limit adenovirally mediated gene expression in the adult mouse eye.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Barriers for retinal gene therapy: separating fact from fiction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Increased expression of VEGF in retinal pigmented epithelial cells is not sufficient to cause choroidal neovascularization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Intraocular gutless adenoviral-vectored VEGF stimulates anterior segment but not retinal neovascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Helper-dependent adenovirus for the gene therapy of proliferative retinopathies: stable gene transfer, regulated gene expression and therapeutic efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Müller cells temporarily rescues injured retinal ganglion cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Short communication: protection of axotomized retinal ganglion cells by adenovirally delivered BDNF in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Improved retinal transduction in vivo and photoreceptor-specific transgene expression using adenovirus vectors with modified penton base.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

The X-linked inhibitor of apoptosis (XIAP) prevents cell death in axotomized CNS neurons in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Human immunodeficiency virus type 2 (HIV-2) vector-mediated in vivo gene transfer into adult rabbit retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Effect of GDNF gene transfer into axotomized retinal ganglion cells using in vivo electroporation with a contact lens-type electrode.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Kv1.1 and Kv1.3 channels contribute to the degeneration of retinal ganglion cells after optic nerve transection in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Down-regulation of apoptosis mediators by RNAi inhibits axotomy-induced retinal ganglion cell death in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Distal axonopathy with structural persistence in glaucomatous neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Role of target tissue in regulating the development of retinal ganglion cells in the albino rat: effects of kainate lesions in the superior colliculus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Retinal ganglion cell degeneration following loss of postsynaptic target neurons in the dorsal lateral geniculate nucleus of the adult cat

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Atrophy and degeneration of ganglion cells in central retina following loss of postsynaptic target neurons in the dorsal lateral geniculate nucleus of the adult cat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Potential synergistic protection of retinal ganglion cells from axotomy-induced apoptosis by adenoviral administration of glial cell line-derived neurotrophic factor and X-chromosome-linked inhibitor of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Ciliary neurotrophic factor protects retinal ganglion cells from axotomy-induced apoptosis via modulation of retinal glia in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinal ganglion cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Retinal ganglion cell gene therapy and visual system repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Patterns of retinal ganglion cell survival after brain-derived neurotrophic factor administration in hypertensive eyes of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Gene therapy with brain-derived neurotrophic factor as a protection: retinal ganglion cells in a rat glaucoma model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Synergistic action of brain-derived neurotrophic factor and lens injury promotes retinal ganglion cell survival, but leads to optic nerve dystrophy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Lens-injury-stimulated axonal regeneration throughout the optic pathway of adult rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Prolonged administration of NT-4/5 fails to rescue most axotomized retinal ganglion cells in adult rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Intraocular elevation of cyclic AMP potentiates ciliary neurotrophic factor-induced regeneration of adult rat retinal ganglion cell axons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Astrocyte-derived CNTF switches mature RGCs to a regenerative state following inflammatory stimulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

CNTF promotes survival of retinal ganglion cells after induction of ocular hypertension in rats: the possible involvement of STAT3 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Effect of CNTF on retinal ganglion cell survival in experimental glaucoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Ciliary neurotrophic factor protects retinal ganglion cells from secondary cell death during acute autoimmune optic neuritis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Delivery of ciliary neurotrophic factor via lentiviral-mediated transfer protects axotomized retinal ganglion cells for an extended period of time

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Fibroblast growth factor-2 gene delivery stimulates axon growth by adult retinal ganglion cells after acute optic nerve injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Extracellular signal-regulated kinases 1/2 are required for adult retinal ganglion cell axon regeneration induced by fibroblast growth factor-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

In vivo neurotrophic effects of GDNF on axotomized retinal ganglion cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Neurturin enhances the survival of axotomized retinal ganglion cells in vivo: combined effects with glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

TUNEL-positive ganglion cells in human primary open-angle glaucoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Real-time imaging of single nerve cell apoptosis in retinal neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Neurotrophin signal transduction in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Extracellular signal-regulated kinase 1/2 mediates survival, but not axon regeneration, of adult injured central nervous system neurons in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Activation of the extracellular signal-regulated kinase 1/2 pathway by AAV gene transfer protects retinal ganglion cells in glaucoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Long-term activation of c-Fos and c-Jun in optic nerve head astrocytes in experimental ocular hypertension in monkeys and after exposure to elevated pressure in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

The transcription factor c-jun is activated in retinal ganglion cells in experimental rat glaucoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Long-term in vivo inhibition of CNS neurodegeneration by Bcl-XL gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

BAG1 promotes axonal outgrowth and regeneration in vivo via Raf-1 and reduction of ROCK activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Ocular neuroprotection by siRNA targeting caspase-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

X-linked IAP is a direct inhibitor of cell-death proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Baculoviral IAP repeat-containing-4 protects optic nerve axons in a rat glaucoma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

XIAP-mediated neuroprotection in retinal ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Optimized allotopic expression of the human mitochondrial ND4 prevents blindness in a rat model of mitochondrial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Leber hereditary optic neuropathy gene therapy clinical trial recruitment: year 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Recent clinical findings with memantine should not mean that the idea of neuroprotection in glaucoma is abandoned

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Real-Time dynamics of Ca2+, caspase-3/7, and morphological changes in retinal ganglion cell apoptosis under elevated pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Superoxide is an associated signal for apoptosis in axonal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Haem oxygenase-1 gene transfer protects retinal ganglion cells from ischaemia/reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Functional human heme oxygenase has a neuroprotective effect on adult rat ganglion cells after pressure-induced ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Inhibition of p75(NTR) in glia potentiates TrkA-mediated survival of injured retinal ganglion cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Friend or foe? Resolving the impact of glial responses in glaucoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Switching mature retinal ganglion cells to a robust growth state in vivo: gene expression and synergy with RhoA inactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

TrkB gene transfer protects retinal ganglion cells from axotomy-induced death in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

7 January 2021

Intraocular expression of endostatin reduces VEGF-induced retinal vascular permeability, neovascularization, and retinal detachment

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

7 January 2021

Ocular gene delivery using lentiviral vectors

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

7 January 2021

Bax antisense oligonucleotides reduce axotomy-induced retinal ganglion cell death in vivo by reduction of Bax protein expression

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

7 January 2021

The physiological function of nerve growth factor in the central nervous system: comparison with the periphery

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

7 January 2021

Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells in vivo does not exclusively depend on phosphatidyl-inositol-3'-kinase/protein kinase B signaling

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

7 January 2021

Expression of specific tubulin isotypes increases during regeneration of injured CNS neurons, but not after the application of brain-derived neurotrophic factor (BDNF).

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

7 January 2021

Lens injury stimulates axon regeneration in the mature rat optic nerve

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

7 January 2021

Injury-induced upregulation of bFGF and CNTF mRNAS in the rat retina

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

7 January 2021

Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats.

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

7 January 2021

Ciliary neurotrophic factor and stress stimuli activate the Jak-STAT pathway in retinal neurons and glia

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

7 January 2021

Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic mice overexpressing bcl-2

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

7 January 2021

Inactivation of Rho signaling pathway promotes CNS axon regeneration

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.142

7 January 2021

Identifiers

DOI

10.1038/GT.2011.142

1 reference

25 August 2017

1 reference

PubMed ID

21975466