(Q37957965)

25 August 2017

Investigational NMDA receptor modulators for depression (English)

1 reference

Agnieszka Pałucha-Poniewiera

25 August 2017

Agnieszka Pałucha-Poniewiera

2

0 references

Bernadeta Szewczyk

Bernadeta Szewczyk

1

0 references

Gabriel Nowak

Gabriel Nowak

5

0 references

Andrzej Pilc

4

Andrzej Pilc

1 reference

25 August 2017

3

Ewa Poleszak

1 reference

PubMed ID

22097925

25 August 2017

language of work or name

English

0 references

publication date

21 November 2011

1 reference

Expert Opinion on Investigational Drugs

25 August 2017

1 reference

25 August 2017

21

1 reference

25 August 2017

1

1 reference

25 August 2017

91-102

1 reference

Increased levels of glutamate in brains from patients with mood disorders.

25 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Emerging role of glutamate in the pathophysiology of major depressive disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Beyond monoamines: glutamatergic function in mood disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Clinical studies implementing glutamate neurotransmission in mood disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Functional antagonists at the NMDA receptor complex exhibit antidepressant actions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Potential antidepressive properties of amantadine, memantine and bifemelane

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Antidepressant-like effects of a partial agonist at strychnine-insensitive glycine receptors and a competitive NMDA receptor antagonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Antidepressant activity of non-competitive and competitive NMDA receptor antagonists in a chronic mild stress model of depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Glutamate-based antidepressants: 20 years on.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Antidepressant effects of ketamine in depressed patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

A nomenclature for ligand-gated ion channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Cloning by functional expression of a member of the glutamate receptor family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Molecular cloning and characterization of the rat NMDA receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Glutamate receptor ion channels: structure, regulation, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Magnesium gates glutamate-activated channels in mouse central neurones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Polyamines regulate glycine interaction with the N-methyl-D-aspartate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Polyamine and ifenprodil interactions with the NMDA receptor's glycine site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Interactions of polyamines with ion channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Four residues of the extracellular N-terminal domain of the NR2A subunit control high-affinity Zn2+ binding to NMDA receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Protons trap NR1/NR2B NMDA receptors in a nonconducting state.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Modulation of the N-methyl-D-aspartate channel by extracellular H+

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

NMDA receptor channels: subunit-specific potentiation by reducing agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Family history of alcohol dependence and initial antidepressant response to an N-methyl-D-aspartate antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Rapid decrease in depressive symptoms with an N-methyl-d-aspartate antagonist in ECT-resistant major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Ketamine and the next generation of antidepressants with a rapid onset of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Psychiatric safety of ketamine in psychopharmacology research

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Signaling pathways underlying the rapid antidepressant actions of ketamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Role of mTOR in physiology and pathology of the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

mTOR signaling: at the crossroads of plasticity, memory and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

mTOR inhibitors: facing new challenges ahead

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

A double-blind, placebo-controlled study of memantine in the treatment of major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

The role of zinc in neurodegenerative inflammatory pathways in depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Zinc supplementation augments efficacy of imipramine in treatment resistant patients: a double blind, placebo-controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

The involvement of NMDA and AMPA receptors in the mechanism of antidepressant-like action of zinc in the forced swim test

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Zinc-induced adaptive changes in NMDA/glutamatergic and serotonergic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Rapid recovery from major depression using magnesium treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

A pilot study of magnesium aspartate hydrochloride (Magnesiocard) as a mood stabilizer for rapid cycling bipolar affective disorder patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Red blood cell magnesium and chronic fatigue syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Treatment of severe mania with intravenous magnesium sulphate as a supplementary therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Glutamate-based therapeutic approaches: NR2B receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Phenylethanolamines inhibit NMDA receptors by enhancing proton inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Genetic inactivation of the NMDA receptor NR2A subunit has anxiolytic- and antidepressant-like effects in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Pharmacology and functions of metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Homer: a protein that selectively binds metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

A novel, competitive mGlu(5) receptor antagonist (LY344545) blocks DHPG-induced potentiation of NMDA responses but not the induction of LTP in rat hippocampal slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Metabotropic glutamate 5 receptor antagonism is associated with antidepressant-like effects in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

The olfactory bulbectomised rat as a model of depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

Reduced metabotropic glutamate receptor 5 density in major depression determined by [(11)C]ABP688 PET and postmortem study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.638916

10.1517/13543784.2012.638916

21 January 2018

Identifiers

DOI

1 reference

25 August 2017

1 reference

PubMed ID

22097925