(Q37961913)

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The role of Toll-like receptors and adaptive immunity in the development of protective or pathological immune response triggered by the Trypanosoma cruzi protozoan.

scientific article published on December 2011

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22122446%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

The role of Toll-like receptors and adaptive immunity in the development of protective or pathological immune response triggered by the Trypanosoma cruzi protozoan (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22122446%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Trypanosoma cruzi

0 references

toll-like receptor

0 references

Natalia Lorena Guiñazú

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22122446%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

author name string

Andrea Pellegrini

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22122446%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Laura Giordanengo

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22122446%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Roxana Carolina Cano

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22122446%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Susana Gea

5

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22122446%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

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1 December 2011

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Europe PubMed Central

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17 January 2020

number of pages

13

1 reference

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Future Microbiology

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22122446%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22122446%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

12

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22122446%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1521-1533

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22122446%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Chagas heart disease pathogenesis: one mechanism or many?

1 reference

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21 January 2018

The significance of autoimmunity in the pathogenesis of chagas heart disease

1 reference

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21 January 2018

The importance of aberrant T-cell responses in Chagas disease.

1 reference

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21 January 2018

Pathogenesis of chronic Chagas heart disease

1 reference

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21 January 2018

Cytokines and cell adhesion receptors in the regulation of immunity to Trypanosoma cruzi

1 reference

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21 January 2018

The role of parasite persistence in pathogenesis of Chagas heart disease

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas disease

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Etiology of Chagas disease myocarditis: autoimmunity, parasite persistence, or both?

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Cooperation of Toll-like receptor signals in innate immune defence

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Trypanosoma cruzi and its components as exogenous mediators of inflammation recognized through Toll-like receptors.

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Immune system recognition of Trypanosoma cruzi

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

The innate immune response to Trypanosoma cruzi infection

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Importance of TLR2 on hepatic immune and non-immune cells to attenuate the strong inflammatory liver response during Trypanosoma cruzi acute infection

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Regulation of lung injury and repair by Toll-like receptors and hyaluronan

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Mammalian toll-like receptors: from endogenous ligands to tissue regeneration.

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Rab5 activation by Toll-like receptor 2 is required for Trypanosoma cruzi internalization and replication in macrophages

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi.

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism.

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

The Trypanosoma cruzi Tc52-released protein induces human dendritic cell maturation, signals via Toll-like receptor 2, and confers protection against lethal infection

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

TLR2, TLR4 and TLR9 are differentially modulated in liver lethally injured from BALB/c and C57BL/6 mice during Trypanosoma cruzi acute infection.

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

DNA from protozoan parasites Babesia bovis, Trypanosoma cruzi, and T. brucei is mitogenic for B lymphocytes and stimulates macrophage expression of interleukin-12, tumor necrosis factor alpha, and nitric oxide

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88.

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Insufficient TLR activation contributes to the slow development of CD8+ T cell responses in Trypanosoma cruzi infection

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Impaired innate immunity in Tlr4(-/-) mice but preserved CD8+ T cell responses against Trypanosoma cruzi in Tlr4-, Tlr2-, Tlr9- or Myd88-deficient mice

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Toll-like receptors and adaptor molecules in liver disease: update

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Liver: An organ with predominant innate immunity

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

The liver as a lymphoid organ

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs.

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Trypanosoma cruzi infection induces a global host cell response in cardiomyocytes

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Targeting caspases in intracellular protozoan infections.

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Cruzipain, a major Trypanosoma cruzi antigen, promotes arginase-2 expression and survival of neonatal mouse cardiomyocytes

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Different signaling pathways are involved in cardiomyocyte survival induced by a Trypanosoma cruzi glycoprotein.

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Trypanosoma cruzi: phosphatidylinositol 3-kinase and protein kinase B activation is associated with parasite invasion

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Activation of Transcription Factors AP-1 and NF-κB in Murine Chagasic Myocarditis

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Toll-like receptor 2 regulates interleukin-1beta-dependent cardiomyocyte hypertrophy triggered by Trypanosoma cruzi

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Parasite cysteine proteinase interactions with alpha 2-macroglobulin or kininogens: differential pathways modulating inflammation and innate immunity in infection by pathogenic trypanosomatids

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Cutting edge: bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization.

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Bradykinin B2 Receptors of dendritic cells, acting as sensors of kinins proteolytically released by Trypanosoma cruzi, are critical for the development of protective type-1 responses

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Proteolytic generation of kinins in tissues infected by Trypanosoma cruzi depends on CXC chemokine secretion by macrophages activated via Toll-like 2 receptors.

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Pattern recognition receptors and inflammation

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

The adipocyte as an important target cell for Trypanosoma cruzi infection

1 reference

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21 January 2018

Trypanosoma cruzi infection of cultured adipocytes results in an inflammatory phenotype

1 reference

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21 January 2018

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

1 reference

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21 January 2018

The many faces of macrophage activation

1 reference

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21 January 2018

Arginase induction promotes Trypanosoma cruzi intracellular replication in Cruzipain-treated J774 cells through the activation of multiple signaling pathways

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

DNA sequences encoding CD4+ and CD8+ T-cell epitopes are important for efficient protective immunity induced by DNA vaccination with a Trypanosoma cruzi gene

1 reference

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21 January 2018

Assembly of the human neutrophil NADPH oxidase involves binding of p67phox and flavocytochrome b to a common functional domain in p47phox.

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Induction of NADPH oxidase activity and reactive oxygen species production by a single Trypanosoma cruzi antigen.

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Induction of macrophage activation and opsonizing antibodies by Trypanosoma cruzi subpopulations

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Production of hydrogen peroxide by peripheral blood monocytes and specific macrophages during experimental infection with Trypanosoma cruzi in vivo.

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Cutting edge: MyD88 controls phagocyte NADPH oxidase function and killing of gram-negative bacteria.

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.

1 reference

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21 January 2018

Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: consequences for oxidative killing and role of microbial peroxiredoxins in infectivity

1 reference

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21 January 2018

Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages

1 reference

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21 January 2018

Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species.

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21 January 2018

An overview of chagasic cardiomyopathy: pathogenic importance of oxidative stress

1 reference

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21 January 2018

Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Functional and antigenic properties of the major cysteine proteinase (GP57/51) of Trypanosoma cruzi

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Induction of antibodies reactive to cardiac myosin and development of heart alterations in cruzipain-immunized mice and their offspring

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Cruzipain induces autoantibodies against cardiac muscarinic acetylcholine receptors. Functional and pathological implications

1 reference

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21 January 2018

Sulfates are main targets of immune responses to cruzipain and are involved in heart damage in BALB/c immunized mice

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Humoral immune response to cruzipain and cardiac dysfunction in chronic Chagas disease

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Immune response to a major Trypanosoma cruzi antigen, cruzipain, is differentially modulated in C57BL/6 and BALB/c mice.

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Cardiac myosin autoimmunity in acute Chagas' heart disease

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Elicitation of specific, Th1-biased immune response precludes skeletal muscle damage in cruzipain-vaccinated mice

1 reference

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21 January 2018

Spleen B cells from BALB/c are more prone to activation than spleen B cells from C57BL/6 mice during a secondary immune response to cruzipain.

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Determinations of B cell fate in immunity and autoimmunity

1 reference

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21 January 2018

Cutting edge: IL-4-mediated protection of primary B lymphocytes from apoptosis via Stat6-dependent regulation of glycolytic metabolism

1 reference

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21 January 2018

Galectin-3 mediates IL-4-induced survival and differentiation of B cells: functional cross-talk and implications during Trypanosoma cruzi infection.

1 reference

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21 January 2018

Vaccination approaches against Trypanosoma cruzi infection

1 reference

https://api.crossref.org/works/10.2217%2FFMB.11.122

21 January 2018

Cruzipain induces both mucosal and systemic protection against Trypanosoma cruzi in mice

1 reference

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21 January 2018

Use of a purified Trypanosoma cruzi antigen and CpG oligodeoxynucleotides for immunoprotection against a lethal challenge with trypomastigotes

1 reference

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21 January 2018

Prime-boost immunization with cruzipain co-administered with MALP-2 triggers a protective immune response able to decrease parasite burden and tissue injury in an experimental Trypanosoma cruzi infection model

1 reference

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21 January 2018

Oral vaccination with Salmonella enterica as a cruzipain-DNA delivery system confers protective immunity against Trypanosoma cruzi

1 reference

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21 January 2018

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