(Q36743540)

16 August 2017

1 reference

title

Cooperation of Toll-like receptor signals in innate immune defence (English)

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toll-like receptor TLR1:TLR2 signaling pathway

16 August 2017

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1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0038123

toll-like receptor TLR6:TLR2 signaling pathway

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Gene Ontology release 2020-05-02

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2

Alan Sher

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16 August 2017

1

Giorgio Trinchieri

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16 August 2017

1 March 2007

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Nature Reviews Immunology

16 August 2017

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16 August 2017

7

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16 August 2017

3

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16 August 2017

179-190

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Pathogen recognition and innate immunity

16 August 2017

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31 March 2020

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

31 March 2020

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The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

31 March 2020

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31 March 2020

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Toll-like receptors, endogenous ligands, and systemic autoimmune disease.

31 March 2020

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Ligand recognition by antigen-presenting cell C-type lectin receptors

31 March 2020

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Dectin-1: a signalling non-TLR pattern-recognition receptor

31 March 2020

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TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity

31 March 2020

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Toll-like receptor control of the adaptive immune responses

31 March 2020

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Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.

31 March 2020

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Synergy between TLR2 and TLR4: a safety mechanism

31 March 2020

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Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways

31 March 2020

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Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

31 March 2020

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Synergistic activation of innate immunity by double-stranded RNA and CpG DNA promotes enhanced antitumor activity

31 March 2020

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A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells.

31 March 2020

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Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells

31 March 2020

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IL-10 released by concomitant TLR2 stimulation blocks the induction of a subset of Th1 cytokines that are specifically induced by TLR4 or TLR3 in human dendritic cells

31 March 2020

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The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells

31 March 2020

1 reference

The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells

31 March 2020

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Microbial recognition via Toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering

31 March 2020

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T-cell control of IL-12p75 production

31 March 2020

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T cell-independent, TLR-induced IL-12p70 production in primary human monocytes

31 March 2020

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Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding protein

31 March 2020

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Toll-like receptor signaling stimulates cell cycle entry and progression in fibroblasts

31 March 2020

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CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal

31 March 2020

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MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists

31 March 2020

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TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis.

31 March 2020

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Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection

31 March 2020

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Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

31 March 2020

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Toll-like receptors 2 and 4 activate STAT1 serine phosphorylation by distinct mechanisms in macrophages

31 March 2020

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Reduced expression of IL-12 p35 by SJL/J macrophages responding to Theiler's virus infection is associated with constitutive activation of IRF-3.

31 March 2020

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Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction

31 March 2020

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Negative regulation of toll-like receptor-mediated immune responses

31 March 2020

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Synergistic enhancement of Toll-like receptor responses by NOD1 activation

31 March 2020

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Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists

31 March 2020

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Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in h

31 March 2020

1 reference

Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells

31 March 2020

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NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

31 March 2020

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Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

31 March 2020

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NOD2 regulation of Toll-like receptor responses and the pathogenesis of Crohn's disease

31 March 2020

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Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease

31 March 2020

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Signalling pathways and molecular interactions of NOD1 and NOD2

31 March 2020

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Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

31 March 2020

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NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

31 March 2020

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Unraveling the NALP-3/IL-1beta inflammasome: a big lesson from a small mutation

31 March 2020

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Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA

31 March 2020

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Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

31 March 2020

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Cryopyrin activates the inflammasome in response to toxins and ATP

31 March 2020

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The inflammasome: first line of the immune response to cell stress

31 March 2020

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Gout-associated uric acid crystals activate the NALP3 inflammasome

31 March 2020

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Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

31 March 2020

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Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf

31 March 2020

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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

31 March 2020

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Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

31 March 2020

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Phagocytosis of microbes: complexity in action

31 March 2020

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Mycobacterium tuberculosis lipoarabinomannan-mediated IRAK-M induction negatively regulates Toll-like receptor-dependent interleukin-12 p40 production in macrophages

31 March 2020

1 reference

The beta-glucan receptor dectin-1 functions together with TLR2 to mediate macrophage activation by mycobacteria

31 March 2020

1 reference

Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins

31 March 2020

1 reference

Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors

31 March 2020

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Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival

31 March 2020

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Cutting Edge: TREM-2 Attenuates Macrophage Activation

31 March 2020

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Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12.

31 March 2020

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Suppression of Il-12 transcription in macrophages following Fc gamma receptor ligation

31 March 2020

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Ligation of the FcR gamma chain-associated human osteoclast-associated receptor enhances the proinflammatory responses of human monocytes and neutrophils

31 March 2020

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Myeloid differentiation factor 88 is required for cross-priming in vivo.

31 March 2020

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MyD88-mediated stabilization of interferon-gamma-induced cytokine and chemokine mRNA

31 March 2020

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Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis

31 March 2020

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Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

31 March 2020

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Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis

31 March 2020

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Toll-like receptor 2 controls expansion and function of regulatory T cells

31 March 2020

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Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

31 March 2020

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Role for TLR2 in NK cell-mediated control of murine cytomegalovirus in vivo

31 March 2020

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MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo

31 March 2020

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Toll-like receptors are temporally involved in host defense.

31 March 2020

1 reference

TLR-dependent induction of IFN-beta mediates host defense against Trypanosoma cruzi

31 March 2020

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p47 GTPases: regulators of immunity to intracellular pathogens

31 March 2020

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Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi.

31 March 2020

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Towards subtlety: understanding the role of Toll-like receptor signaling in susceptibility to human infections

31 March 2020

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Inherited disorders of human Toll-like receptor signaling: immunological implications.

31 March 2020

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Therapeutic potential of Toll-like receptor 9 activation

31 March 2020

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HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates

31 March 2020

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Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4+ T cell response

31 March 2020

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Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo

31 March 2020

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Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity

31 March 2020

1 reference

Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...

31 March 2020

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Enhancement and diversification of IFN induction by IRF-7-mediated positive feedback

31 March 2020

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IRF family proteins and type I interferon induction in dendritic cells

31 March 2020

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Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

31 March 2020

1 reference

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

31 March 2020

1 reference

Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes

31 March 2020

1 reference

Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation

31 March 2020

1 reference

Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors

31 March 2020

1 reference

How C-type lectins detect pathogens

31 March 2020

1 reference

Fcgamma receptors: old friends and new family members

31 March 2020

1 reference

TREM-1 amplifies inflammation and is a crucial mediator of septic shock

31 March 2020

1 reference

Interleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice.

31 March 2020

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Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology

31 March 2020

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Type I interferons and IL-12: convergence and cross-regulation among mediators of cellular immunity

31 March 2020

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Reciprocal activating interaction between natural killer cells and dendritic cells

31 March 2020

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The reciprocal interaction of NK cells with plasmacytoid or myeloid dendritic cells profoundly affects innate resistance functions.

31 March 2020

1 reference

Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRI2038

1 reference

16 August 2017

1 reference

PubMed ID

17318230