(Q37962013)

26 August 2017

title

Emerging promise of epigenetics and DNA methylation for the diagnosis and management of women's cancers (English)

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26 August 2017

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Allison Jones

1

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26 August 2017

Matthias Lechner

2

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26 August 2017

Evangelia-Ourania Fourkala

3

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26 August 2017

Rebecca Kristeleit

4

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26 August 2017

Martin Widschwendter

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26 August 2017

language of work or name

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1 February 2010

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26 August 2017

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26 August 2017

volume

2

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26 August 2017

issue

1

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26 August 2017

page(s)

9-38

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The history of cancer epigenetics

26 August 2017

cites work

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21 January 2018

Epigenetics in cancer

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DNA methylation patterns and epigenetic memory

21 January 2018

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Methylation-induced repression--belts, braces, and chromatin

21 January 2018

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Worms gang up on bacteria

21 January 2018

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CpG-rich islands and the function of DNA methylation

21 January 2018

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The role of DNA methylation in mammalian epigenetics

21 January 2018

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Stability and flexibility of epigenetic gene regulation in mammalian development

21 January 2018

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Cross-talk between aging and cancer: the epigenetic language

21 January 2018

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The epigenomics of cancer

21 January 2018

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Perceptions of epigenetics

21 January 2018

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DNA methylation changes in ovarian cancer: implications for early diagnosis, prognosis and treatment

21 January 2018

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Epigenetic considerations for endometrial cancer prevention, diagnosis and treatment

21 January 2018

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Epigenetics of cervical cancer. An overview and therapeutic perspectives

21 January 2018

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Hypomethylation distinguishes genes of some human cancers from their normal counterparts

21 January 2018

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Review of anthropometric factors and breast cancer risk

21 January 2018

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Alfred Knudson and his two-hit hypothesis. (Interview by Ezzie Hutchinson).

21 January 2018

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Epigenetic stem cell signature in cancer

21 January 2018

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Epigenetic reprogramming and imprinting in origins of disease

21 January 2018

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Neonatal exposure to diethylstilbestrol alters the expression of DNA methyltransferases and methylation of genomic DNA in the epididymis of mice.

21 January 2018

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Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen.

21 January 2018

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Epigenotyping in peripheral blood cell DNA and breast cancer risk: a proof of principle study

21 January 2018

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Methylation of either cytosine in the recognition sequence CGCG inhibits ThaI cleavage of DNA.

21 January 2018

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The 5′-cytosine in CCGG1is methylated in two eukaryotic DNAS and Msp I is sensitive to methylatlon at this site

21 January 2018

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The effect of sequence specific DNA methylation on restriction endonuclease cleavage

21 January 2018

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Cancer epigenomics: DNA methylomes and histone-modification maps

21 January 2018

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Hunting for the 5th base: Techniques for analyzing DNA methylation

21 January 2018

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Fingerprinting genomes using PCR with arbitrary primers

21 January 2018

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SATR-1 hypomethylation is a common and early event in breast cancer

21 January 2018

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A genomic scanning method for higher organisms using restriction sites as landmarks

21 January 2018

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The Agilent in situ-synthesized microarray platform

21 January 2018

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DNA methylation and ovarian cancer. I. Analysis of CpG island hypermethylation in human ovarian cancer using differential methylation hybridization.

21 January 2018

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Differential methylation hybridization array of endometrial cancers reveals two novel cancer-specific methylation markers

21 January 2018

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A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands

21 January 2018

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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

21 January 2018

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MethyLight: a high-throughput assay to measure DNA methylation

21 January 2018

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Sensitive Melting Analysis after Real Time- Methylation Specific PCR (SMART-MSP): high-throughput and probe-free quantitative DNA methylation detection

21 January 2018

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In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis

21 January 2018

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COBRA: a sensitive and quantitative DNA methylation assay

21 January 2018

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Methylated-CpG island recovery assay: a new technique for the rapid detection of methylated-CpG islands in cancer

21 January 2018

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MIRA-assisted microarray analysis, a new technology for the determination of DNA methylation patterns, identifies frequent methylation of homeodomain-containing genes in lung cancer cells

21 January 2018

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Methylation of homeobox genes is a frequent and early epigenetic event in breast cancer

21 January 2018

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Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells

21 January 2018

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The 5-methylcytosine content of DNA from human tumors

21 January 2018

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DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight

21 January 2018

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Illumina universal bead arrays

21 January 2018

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High-throughput DNA methylation profiling using universal bead arrays

21 January 2018

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Rapid quantitation of methylation differences at specific sites using methylation-sensitive single nucleotide primer extension (Ms-SNuPE)

21 January 2018

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Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients

21 January 2018

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The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

21 January 2018

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DNA methylation landscapes: provocative insights from epigenomics

21 January 2018

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Massively parallel bisulphite pyrosequencing reveals the molecular complexity of breast cancer-associated cytosine-methylation patterns obtained from tissue and serum DNA.

21 January 2018

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Continuous base identification for single-molecule nanopore DNA sequencing

21 January 2018

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The cell of origin of ovarian epithelial tumours

21 January 2018

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Tumor Cell-SpecificBRCA1andRASSF1AHypermethylation in Serum, Plasma, and Peritoneal Fluid from Ovarian Cancer Patients

21 January 2018

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Promoter Hypermethylation as an Epigenetic Component in Type I and Type II Endometrial Cancers

21 January 2018

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Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers

21 January 2018

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Assessment of gene promoter hypermethylation for detection of cervical neoplasia.

21 January 2018

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DNA methylation in breast cancer

21 January 2018

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Prognostic DNA methylation biomarkers in ovarian cancer.

21 January 2018

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The acquisition of hMLH1 methylation in plasma DNA after chemotherapy predicts poor survival for ovarian cancer patients

21 January 2018

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Aneuploidy predicts outcome in patients with endometrial carcinoma and is related to lack of CDH13 hypermethylation.

21 January 2018

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DNA hypermethylation, Her-2/neu overexpression and p53 mutations in ovarian carcinoma

21 January 2018

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Demethylation of the MCJ gene in stage III/IV epithelial ovarian cancer and response to chemotherapy.

21 January 2018

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Circulating tumor-specific DNA: a marker for monitoring efficacy of adjuvant therapy in cancer patients

21 January 2018

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Methylated NEUROD1 promoter is a marker for chemosensitivity in breast cancer.

21 January 2018

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Association of DNA methylation of phosphoserine aminotransferase with response to endocrine therapy in patients with recurrent breast cancer

21 January 2018

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21 January 2018

The mammalian epigenome

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MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death

21 January 2018

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Current status of epigenetic treatment in myelodysplastic syndromes

21 January 2018

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Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma

21 January 2018

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Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells.

21 January 2018

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A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation

21 January 2018

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Reactivation of epigenetically silenced genes by DNA methyltransferase inhibitors: basic concepts and clinical applications

21 January 2018

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A phase 1 pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advanced solid tumors

21 January 2018

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Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.

21 January 2018

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Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine.

21 January 2018

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Epigenetic activation of tumor suppressor microRNAs in human cancer cells

21 January 2018

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DNA hypomethylation and ovarian cancer biology.

21 January 2018

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Induction of Tumors in Mice by Genomic Hypomethylation

21 January 2018

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Role of DNA hypomethylation in the development of the resistance to doxorubicin in human MCF-7 breast adenocarcinoma cells

21 January 2018

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Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach.

21 January 2018

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Human papillomavirus and cervical cancer

21 January 2018

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Targeting DNA methylation

21 January 2018

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Trapped in action: direct visualization of DNA methyltransferase activity in living cells.

21 January 2018

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5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal

21 January 2018

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Cellular differentiation, cytidine analogs and DNA methylation

21 January 2018

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Epigenetic therapy of cancer: past, present and future

21 January 2018

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Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides

21 January 2018

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Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU).

21 January 2018

1 reference

Alcohol, tobacco and breast cancer--collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease

21 January 2018

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Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors

21 January 2018

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Epigenetic modifiers: basic understanding and clinical development.

21 January 2018

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Phase I study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors.

21 January 2018

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A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia

21 January 2018

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Synthesis and in vitro evaluation of biotinylated RG108: a high affinity compound for studying binding interactions with human DNA methyltransferases

21 January 2018

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Phase II trial of cisplatin plus decitabine, a new DNA hypomethylating agent, in patients with advanced squamous cell carcinoma of the cervix

21 January 2018

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Phase I study of epigenetic modulation with 5-azacytidine and valproic acid in patients with advanced cancers

21 January 2018

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Observation of Muon Neutrino Disappearance with the MINOS Detectors in the NuMI Neutrino Beam

21 January 2018

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Histone deacetylases (HDACs): characterization of the classical HDAC family

21 January 2018

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Chromatin modifications and their function

21 January 2018

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Acetylation is indispensable for p53 activation

21 January 2018

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Anticancer activities of histone deacetylase inhibitors

21 January 2018

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An acetylation site in the middle domain of Hsp90 regulates chaperone function

21 January 2018

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Role of histone N-terminal tails and their acetylation in nucleosome dynamics

21 January 2018

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Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

21 January 2018

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Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation

21 January 2018

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Selective growth inhibition of tumor cells by a novel histone deacetylase inhibitor, NVP-LAQ824.

21 January 2018

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Histone deacetylase inhibitors in cancer treatment

21 January 2018

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Chromatin-immune connections: regulation of MHC and other genes

21 January 2018

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Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

21 January 2018

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Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling

21 January 2018

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Histone deacetylase inhibitor FK228 inhibits tumor angiogenesis

21 January 2018

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Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model

21 January 2018

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HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

21 January 2018

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The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells

21 January 2018

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HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombination

21 January 2018

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Attenuated DNA damage repair by trichostatin A through BRCA1 suppression

21 January 2018

1 reference

Intrauterine factors and risk of breast cancer: a systematic review and meta-analysis of current evidence

21 January 2018

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Drastic decrease of progesterone receptor form B but not A mRNA reflects poor patient prognosis in endometrial cancers

21 January 2018

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Clinical potential of histone deacetylase inhibitors as stand alone therapeutics and in combination with other chemotherapeutics or radiotherapy for cancer

21 January 2018

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HDAC inhibitors: clinical update and mechanism-based potential.

21 January 2018

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Histone deacetylase inhibitors: overview and perspectives

21 January 2018

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Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes

21 January 2018

1 reference

A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies

21 January 2018

1 reference

Radioembolization of liver metastases from colorectal cancer using yttrium-90 microspheres with concomitant systemic oxaliplatin, fluorouracil, and leucovorin chemotherapy.

21 January 2018

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A phase I study of hydralazine to demethylate and reactivate the expression of tumor suppressor genes

21 January 2018

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A phase I trial of depsipeptide (FR901228) in patients with advanced cancer.

21 January 2018

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Increased MDR1 expression in normal and malignant peripheral blood mononuclear cells obtained from patients receiving depsipeptide (FR901228, FK228, NSC630176).

21 January 2018

1 reference

A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors

21 January 2018

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Phase I study of MGCD0103 given as a three-times-per-week oral dose in patients with advanced solid tumors

21 January 2018

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Mutation of ERBB2 provides a novel alternative mechanism for the ubiquitous activation of RAS-MAPK in ovarian serous low malignant potential tumors.

21 January 2018

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Epigenetic silencing of HSulf-1 in ovarian cancer:implications in chemoresistance.

21 January 2018

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Apicidin down-regulates human papillomavirus type 16 E6 and E7 transcripts and proteins in SiHa cervical cancer cells.

21 January 2018

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A phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group study

21 January 2018

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Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer

21 January 2018

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A phase II trial of vorinostat (suberoylanilide hydroxamic acid) in metastatic breast cancer: a California Cancer Consortium study

21 January 2018

1 reference

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.

21 January 2018

1 reference

Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells

21 January 2018

1 reference

MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.

21 January 2018

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Significantly longer progression-free survival with nab-paclitaxel compared with docetaxel as first-line therapy for metastatic breast cancer

21 January 2018

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HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: a proof of principle study.

21 January 2018

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DNA methylation analysis in liquid-based cytology for cervical cancer screening.

21 January 2018

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An epigenetic marker panel for screening and prognostic prediction of ovarian cancer.

21 January 2018

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Differential methylation profile of ovarian cancer in tissues and plasma

21 January 2018

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Evaluation of candidate methylation markers to detect cervical neoplasia

21 January 2018

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Detection of hypermethylated genes in tumor and plasma of cervical cancer patients.

21 January 2018

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Identification of novel DNA methylation markers in cervical cancer

21 January 2018

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Effect of aberrant promoter methylation of FHIT and RASSF1A genes on susceptibility to cervical cancer in a North Indian population

21 January 2018

1 reference

Quantitative methylation-specific PCR for the detection of aberrant DNA methylation in liquid-based Pap tests

21 January 2018

1 reference

Discovery of novel methylation biomarkers in cervical carcinoma by global demethylation and microarray analysis

21 January 2018

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Detection of hypermethylated genes in women with and without cervical neoplasia.

21 January 2018

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Prediction of human papillomavirus 16 e6 gene expression and cervical intraepithelial neoplasia progression by methylation status

21 January 2018

1 reference

Detection of RASSF1A and RARbeta hypermethylation in serum DNA from breast cancer patients

21 January 2018

1 reference

Promoter hypermethylation of p16INK4A, p14ARF, CyclinD2 and Slit2 in serum and tumor DNA from breast cancer patients

21 January 2018

1 reference

Epigenetic analysis of body fluids and tumor tissues: application of a comprehensive molecular assessment for early-stage breast cancer patients.

21 January 2018

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Tumor suppressor gene promoter hypermethylation in serum of breast cancer patients.

21 January 2018

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Detection of breast cancer in nipple aspirate fluid by CpG island hypermethylation

21 January 2018

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Hypermethylated genes as biomarkers of cancer in women with pathologic nipple discharge

21 January 2018

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Anticancer drugs affect the alternative splicing of Bcl-x and other human apoptotic genes

21 January 2018

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Methylation of the insulin-like growth factor binding protein-3 gene and prognosis of epithelial ovarian cancer

21 January 2018

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Aberrant promoter methylation of multiple genes in malignant ovarian tumors and in ovarian tumors with low malignant potential

21 January 2018

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Hypermethylation of 18S and 28S ribosomal DNAs predicts progression-free survival in patients with ovarian cancer.

21 January 2018

1 reference

Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcome

21 January 2018

1 reference

Epigenetic and genetic alternation of PTEN in cervical neoplasm.

21 January 2018

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Hypermethylation of the COX-2 gene is a potential prognostic marker for cervical cancer.

21 January 2018

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Methylation status and expression of human telomerase reverse transcriptase in ovarian and cervical cancer.

21 January 2018

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Global histone modifications in breast cancer correlate with tumor phenotypes, prognostic factors, and patient outcome.

21 January 2018

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Kallikrein 10 (KLK10) methylation as a novel prognostic biomarker in early breast cancer

21 January 2018

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Prognostic significance of RASSF1A promoter methylation in operable breast cancer

21 January 2018

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DNA methylation markers predict outcome in node-positive, estrogen receptor-positive breast cancer with adjuvant anthracycline-based chemotherapy.

21 January 2018

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Multigene methylation in serum of sporadic Chinese female breast cancer patients as a prognostic biomarker

21 January 2018

1 reference

Epigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis

21 January 2018

1 reference

DNA hypermethylation of PITX2 is a marker of poor prognosis in untreated lymph node-negative hormone receptor-positive breast cancer patients

21 January 2018

1 reference

DNA-methylation of the homeodomain transcription factor PITX2 reliably predicts risk of distant disease recurrence in tamoxifen-treated, node-negative breast cancer patients--Technical and clinical validation in a multi-centre setting in collaborati

21 January 2018

1 reference

Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancer

21 January 2018

1 reference

A phase I study of 5-azacytidine (NSC-102816).

21 January 2018

1 reference

Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer

21 January 2018

1 reference

A phase I and pharmacokinetic study of the oral histone deacetylase inhibitor, MS-275, in patients with refractory solid tumors and lymphomas

21 January 2018

1 reference

Phase I and pharmacokinetic study of MS-275, a histone deacetylase inhibitor, in patients with advanced and refractory solid tumors or lymphoma

21 January 2018

1 reference

A microarray-based method for detecting methylated loci

21 January 2018

1 reference

Evaluation of a potential epigenetic biomarker by quantitative methyl-single nucleotide polymorphism analysis

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/EPI.09.47

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26 August 2017

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