(Q37962016)

26 August 2017

Will DNA methylation inhibitors work in solid tumors? A review of the clinical experience with azacitidine and decitabine in solid tumors (English)

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26 August 2017

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Lisa A Cowan

1

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26 August 2017

Sundeep Talwar

series ordinal

2

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26 August 2017

Allen S Yang

series ordinal

3

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26 August 2017

1 February 2010

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26 August 2017

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26 August 2017

2

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26 August 2017

1

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26 August 2017

71-86

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26 August 2017

Epigenetics in cancer

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Gene silencing in cancer in association with promoter hypermethylation

21 January 2018

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Epigenetic therapy of cancer: past, present and future

21 January 2018

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The clinical application of targeting cancer through histone acetylation and hypomethylation

21 January 2018

1 reference

Environmental epigenomics and disease susceptibility

21 January 2018

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Worms gang up on bacteria

21 January 2018

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Aberrant DNA methylation in pediatric patients with acute lymphocytic leukemia

21 January 2018

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The role of DNA hypermethylation in the pathogenesis and prognosis of acute lymphoblastic leukemia

21 January 2018

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Methylation profiling in acute myeloid leukemia.

21 January 2018

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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

21 January 2018

1 reference

5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy

21 January 2018

1 reference

Cellular differentiation, cytidine analogs and DNA methylation

21 January 2018

1 reference

Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B.

21 January 2018

1 reference

Hydroxycarbamide in combination with azacitidine or decitabine is antagonistic on DNA methylation inhibition

21 January 2018

1 reference

Inhibition of DNA methylation and reactivation of silenced genes by zebularine

21 January 2018

1 reference

Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides

21 January 2018

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2'-Deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine: a novel inhibitor of DNA methyltransferase that requires activation by human carboxylesterase 1.

21 January 2018

1 reference

The effects of cladribine and fludarabine on DNA methylation in K562 cells

21 January 2018

1 reference

Mitoxantrone mediates demethylation and reexpression of cyclin d2, estrogen receptor and 14.3.3sigma in breast cancer cells.

21 January 2018

1 reference

N-acetylprocainamide is a less potent inducer of T cell autoreactivity than procainamide

21 January 2018

1 reference

Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine.

21 January 2018

1 reference

Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study

21 January 2018

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DNA methylation and cancer therapy: new developments and expectations

21 January 2018

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Future directions for the use of hypomethylating agents

21 January 2018

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The promises and pitfalls of epigenetic therapies in solid tumours

21 January 2018

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Targeting DNA methylation

21 January 2018

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Combining epigenetic and cytotoxic therapy in the treatment of solid tumors.

21 January 2018

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Epigenetic modulation of solid tumors as a novel approach for cancer immunotherapy

21 January 2018

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Phase III trial of doxorubicin plus cyclophosphamide (AC), docetaxel, and alternating AC and docetaxel as front-line chemotherapy for metastatic breast cancer: Japan Clinical Oncology Group trial (JCOG9802).

21 January 2018

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Systemic therapy for colorectal cancer

21 January 2018

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Phase II study of subcutaneously administered 5-azacytidine (NSC-102816) in patients with metastatic malignant melanoma

21 January 2018

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Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia

21 January 2018

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Combination therapy with DNA methyltransferase inhibitors in hematologic malignancies

21 January 2018

1 reference

Phase II study of low-dose decitabine in combination with imatinib mesylate in patients with accelerated or myeloid blastic phase of chronic myelogenous leukemia.

21 January 2018

1 reference

Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors

21 January 2018

1 reference

Phase II trial of cisplatin plus decitabine, a new DNA hypomethylating agent, in patients with advanced squamous cell carcinoma of the cervix

21 January 2018

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A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer

21 January 2018

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DNA demethylating agents and histone deacetylase inhibitors in hematologic malignancies

21 January 2018

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Phase I study of epigenetic modulation with 5-azacytidine and valproic acid in patients with advanced cancers

21 January 2018

1 reference

A phase I dose-finding study of 5-azacytidine in combination with sodium phenylbutyrate in patients with refractory solid tumors

21 January 2018

1 reference

Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies.

21 January 2018

1 reference

LINE-1 methylation in plasma DNA as a biomarker of activity of DNA methylation inhibitors in patients with solid tumors

21 January 2018

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The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.

21 January 2018

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Limited gene activation in tumor and normal epithelial cells treated with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine

21 January 2018

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Phase I trial of sequential low-dose 5-aza-2'-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma.

21 January 2018

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Sequential 5-Aza-2 deoxycytidine-depsipeptide FR901228 treatment induces apoptosis preferentially in cancer cells and facilitates their recognition by cytolytic T lymphocytes specific for NY-ESO-1.

21 January 2018

1 reference

Rexpression of HLA class I antigens and restoration of antigen-specific CTL response in melanoma cells following 5-aza-2'-deoxycytidine treatment

21 January 2018

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Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies

21 January 2018

1 reference

Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia

21 January 2018

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Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

21 January 2018

1 reference

Azacytidine inhibits RNA methylation at DNMT2 target sites in human cancer cell lines

21 January 2018

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Decitabine effect on tumor global DNA methylation and other parameters in a phase I trial in refractory solid tumors and lymphomas.

21 January 2018

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Phase I study of decitabine-mediated gene expression in patients with cancers involving the lungs, esophagus, or pleura

21 January 2018

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Changes in DNA Methylation Patterns in Subjects Exposed to Low-Dose Benzene

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/EPI.09.44

1 reference

release_63kpcb2cdvcq5e2vjhanr5u4fm

26 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/63kpcb2cdvcq5e2vjhanr5u4fm

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference