(Q37372837)

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Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies.

scientific article published on 22 June 2009

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1 February 2020

Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies (English)

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1 February 2020

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Melanie J. McConnell

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1 February 2020

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Tamer E Fandy

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1 February 2020

James G Herman

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1 February 2020

Patrick Kerns

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1 February 2020

Anchalee Jiemjit

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Elizabeth A Sugar

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Si-Ho Choi

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Allen S Yang

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1 February 2020

Timothy Aucott

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1 February 2020

Tianna Dauses

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Rosalie Odchimar-Reissig

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Jonathan Licht

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Chris Nasrallah

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Marianne K H Kim

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1 February 2020

Weijia Zhang

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1 February 2020

Yezou Sun

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1 February 2020

Anthony Murgo

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1 February 2020

Igor Espinoza-Delgado

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1 February 2020

Katharine Oteiza

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1 February 2020

Ibitayo Owoeye

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1 February 2020

Lewis R Silverman

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1 February 2020

Steven D Gore

22

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1 February 2020

Hetty E Carraway

23

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22 June 2009

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1 February 2020

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1 February 2020

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1 February 2020

2764-2773

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1 February 2020

13

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1 February 2020

Future directions in myelodysplastic syndrome: newer agents and the role of combination approaches

1 reference

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6 September 2017

Induction of hypomethylation and molecular response after decitabine therapy in patients with chronic myelomonocytic leukemia

1 reference

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6 September 2017

Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia

1 reference

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6 September 2017

DNA demethylating agents and histone deacetylase inhibitors in hematologic malignancies

1 reference

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6 September 2017

DNA methyltransferase inhibitors for cancer therapy

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6 September 2017

Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias

1 reference

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6 September 2017

Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756131

6 September 2017

Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756131

6 September 2017

Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia

1 reference

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6 September 2017

DNA methylation and gene silencing in cancer

1 reference

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6 September 2017

Methylation inhibitor therapy in the treatment of myelodysplastic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756131

6 September 2017

The hematopathological basis for studying effects of the demethylating agent 5-aza-2'-deoxycytidine (decitabine) in myelodysplasia

1 reference

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6 September 2017

DNA methyltransferase inhibitors and the development of epigenetic cancer therapies

1 reference

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6 September 2017

Innovative approaches to the clinical development of DNA methylation inhibitors as epigenetic remodeling drugs

1 reference

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6 September 2017

Histone deacetylase inhibitors: insights into mechanisms of lethality

1 reference

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6 September 2017

Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies

1 reference

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6 September 2017

Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS.

1 reference

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6 September 2017

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

1 reference

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6 September 2017

Reactivating the expression of methylation silenced genes in human cancer

1 reference

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6 September 2017

A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer

1 reference

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6 September 2017

A gene hypermethylation profile of human cancer

1 reference

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6 September 2017

A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors

1 reference

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6 September 2017

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756131

6 September 2017

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

1 reference

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6 September 2017

The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.

1 reference

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6 September 2017

Azacytidine causes complex DNA methylation responses in myeloid leukemia

1 reference

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14 September 2017

p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756131

14 September 2017

DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B.

1 reference

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14 September 2017

A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements

1 reference

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14 September 2017

Report of an international working group to standardize response criteria for myelodysplastic syndromes.

1 reference

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28 September 2017

Cellular differentiation, cytidine analogs and DNA methylation

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26 June 2018

Hydroxycarbamide in combination with azacitidine or decitabine is antagonistic on DNA methylation inhibition

1 reference

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2 September 2018

Clinical implications of aberrant DNA methylation patterns in acute myelogenous leukemia

1 reference

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2 September 2018

Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies

1 reference

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2 September 2018

5-Aza-2'-deoxycytidine (decitabine) treatment of hematopoietic malignancies: a multimechanism therapeutic approach?

1 reference

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2 September 2018

Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment

1 reference

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2 September 2018

CDKN2B methylation status and isolated chromosome 7 abnormalities predict responses to treatment with 5-azacytidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19546476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/19546476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing

1 reference

https://pubmed.ncbi.nlm.nih.gov/19546476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myelodysplastic syndromes (MDSs) and acute myelogenous leukemia (AML) comprise a closely linked continuum of malignant hematologic diseases. Introduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/19546476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19546476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms

1 reference

https://pubmed.ncbi.nlm.nih.gov/19546476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2009-02-203547

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1 February 2020

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1 February 2020

1 reference

Europe PubMed Central

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1 February 2020

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