(Q37965230)

26 August 2017

title

GABA(A) receptor physiology and its relationship to the mechanism of action of the 1,5-benzodiazepine clobazam (English)

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26 August 2017

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ChEBI release 2020-05-28

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Raman Sankar

1

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26 August 2017

publication date

1 March 2012

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26 August 2017

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26 August 2017

volume

26

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26 August 2017

issue

3

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26 August 2017

page(s)

229-244

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https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

26 August 2017

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A clinical view of clobazam

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Antiepileptic Properties of Clobazam, a 1–5 Benzodiazepine, in Man

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Clobazam in the treatment of Lennox-Gastaut syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial. STICLO study group

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Clinical pharmacokinetics of nitrazepam

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

The clinical assessment of depression

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Cognitive Effects of Long-Term Benzodiazepine Use

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Clobazam: chemical aspects of the 1,4 and 1,5-benzodiazepines

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Pharmacokinetics of single and multiple doses of clobazam in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Effects of age and antiepileptic drugs on plasma levels and kinetics of clobazam and N-desmethylclobazam

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

A major influence of CYP2C19 genotype on the steady-state concentration of N-desmethylclobazam

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Anticonvulsant Action of a 1,5-Benzodiazepine, Clobazam, in Reflex Epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Comparative anticonvulsant activity and neurotoxicity of clobazam, diazepam, phenobarbital, and valproate in mice and rats

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Review of clinical studies on clobazam

21 January 2018

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https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Immediate effects on human performance of a 1,5-genzodiazepine (clobazam) compared with the 1,4-benzodiazepines, chlordiazepoxide hydrochloride and diazepam

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Studies of clobazam and car-driving

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Some aspects of the effects of clobazam on human psychomotor performance

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Evaluation of the effects of clobazam, A 1,5 benzodiazepine, on mood and psychomotor performance in clinically anxious patients in general practice

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Psychomotor changes during initial day of benzodiazepine medication

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Effects of single oral doses of clobazam, diazepam and lorazepam on performance tasks and memory.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Effects of single oral doses of bromazepam, buspirone and clobazam on performance tasks and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Respiratory and sedative effects of clobazam and clonazepam in volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

GABAA receptor heterogeneity, function, and implications for epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Looking for GABA in all the wrong places: the relevance of extrasynaptic GABA(A) receptors to epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Novel anxiolytics that act as partial agonists at benzodiazepine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Benzodiazepines on trial: a research strategy for their rehabilitation

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

The benzodiazepine binding site of GABA A receptors as a target for the development of novel anxiolytics

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Functional domains of GABAA receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Subunit composition, distribution and function of GABA(A) receptor subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Which GABAA-receptor subtypes really occur in the brain?

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Impact of subunit positioning on GABAA receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

GABA(A) receptor diversity and pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Extrasynaptic GABA(A) receptors and tonic inhibition in rat auditory thalamus.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Benzodiazepine receptor: demonstration in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

GABA-Benzodiazepine-Barbiturate Receptor Interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Molecular basis of pharmacological heterogeneity of GABAA receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Imidazopyridines as a tool for the characterization of benzodiazepine receptors: a proposal for a pharmacological classification as omega receptor subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Effects of clobazam and its active metabolite on GABA-activated currents in rat cerebral neurons in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

A pharmacological profile of clobazam (Mystan), a new antiepileptic drug

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

New 1,5-benzodiazepine compounds: activity at native GABA(A) receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Molecular and neuronal substrate for the selective attenuation of anxiety.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

A new benzodiazepine pharmacology.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Interactions between modulators of the GABA(A) receptor: Stiripentol and benzodiazepines

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Are GABAA receptors containing alpha5 subunits contributing to the sedative properties of benzodiazepine site agonists?

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

The complexity of the GABAA receptor shapes unique pharmacological profiles.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Pharmacology of recombinant gamma-aminobutyric acidA receptors rendered diazepam-insensitive by point-mutated alpha-subunits.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Angelman syndrome (AS, MIM 105830)

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Randomized, phase III study results of clobazam in Lennox-Gastaut syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11599020-000000000-00000

Issues in the clinical use of benzodiazepines: potency, withdrawal, and rebound.

21 January 2018

1 reference

12 December 2020

The use of benzodiazepines in clinical practice

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12 December 2020

A single histidine in GABAA receptors is essential for benzodiazepine agonist binding

1 reference

12 December 2020

Evidence for involvement of GABA in the action of benzodiazepines: studies on rat cerebellum

1 reference

12 December 2020

Clobazam has equivalent efficacy to carbamazepine and phenytoin as monotherapy for childhood epilepsy. Canadian Study Group for Childhood Epilepsy

1 reference

12 December 2020

International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function

1 reference

12 December 2020

A gamma-aminobutyric acid/benzodiazepine receptor complex from bovine cerebral cortex. Improved purification with preservation of regulatory sites and their interactions

1 reference

12 December 2020

Comparative study in mice of ten 1,4-benzodiazepines and of clobazam: anticonvulsant, anxiolytic, sedative, and myorelaxant effects

1 reference

12 December 2020

Pharmacology of benzodiazepine receptors: an update

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12 December 2020

Mice lacking the beta3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome.

1 reference

12 December 2020

In vitro characterization of clobazam metabolism by recombinant cytochrome P450 enzymes: importance of CYP2C19.

1 reference

12 December 2020

Molecular sizes of benzodiazepine receptors and the interacting gaba receptors in the membrane are identical

1 reference

12 December 2020

The effects of vigabatrin on spike and wave discharges in WAG/Rij rats

1 reference

12 December 2020

The effects of benzodiazepines on cognition.

1 reference

12 December 2020

The benzodiazepine--GABA--chloride ionophore receptor complex: common site of minor tranquilizer action

1 reference

12 December 2020

Current potentiation by diazepam but not GABA sensitivity is determined by a single histidine residue.

1 reference

12 December 2020

Pharmacological and toxicological properties of clobazam (1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-diketo-3H-1,5-benzodiazepine), a new psychotherapeutic agent.

1 reference

12 December 2020

Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor.

1 reference

12 December 2020

Possible involvement of GABA in the central actions of benzodiazepines

1 reference

12 December 2020

10.2165/11599020-000000000-00000

Identifiers

DOI

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Dimensions Publication ID

26 August 2017

1018594740

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