(Q37972998)

26 August 2017

Kynurenic acid: a metabolite with multiple actions and multiple targets in brain and periphery (English)

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26 August 2017

2

Andrea Cozzi

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26 August 2017

Flavio Moroni

1

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PubMed ID

22215208

26 August 2017

Maria Sili

series ordinal

3

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PubMed ID

22215208

26 August 2017

Guido Mannaioni

series ordinal

4

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26 August 2017

4 January 2012

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Journal of Neural Transmission

26 August 2017

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26 August 2017

119

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26 August 2017

2

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26 August 2017

133-139

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https://scigraph.springernature.com/pub.10.1007/s00702-011-0763-x

26 August 2017

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cites work

The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications

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12 December 2020

On the antioxidant properties of kynurenic acid: free radical scavenging activity and inhibition of oxidative stress.

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12 December 2020

Comparative behavioral and pharmacological studies with centrally administered kynurenine and kynurenic acid in rats.

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12 December 2020

Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration

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12 December 2020

The conversion of tryptophan to kynurenine in liver. II. The enzymatic hydrolysis of formylkynurenine.

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12 December 2020

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

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12 December 2020

Nicotinylalanine increases the formation of kynurenic acid in the brain and antagonizes convulsions.

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12 December 2020

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

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12 December 2020

A glycine site associated with N-methyl-D-aspartic acid receptors: characterization and identification of a new class of antagonists

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12 December 2020

Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα₁₃ and β-arrestin-2.

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12 December 2020

Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain.

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12 December 2020

The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease

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12 December 2020

Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures

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12 December 2020

Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats.

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12 December 2020

Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain

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12 December 2020

An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells

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12 December 2020

Biochemical and behavioural studies on indole-pyruvic acid: a keto-analogue of tryptophan.

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12 December 2020

Modulation of Quinolinic and Kynurenic Acid Content in the Rat Brain: Effects of Endotoxins and Nicotinylalanine

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12 December 2020

G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast.

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12 December 2020

Presynaptic kynurenate-sensitive receptors inhibit glutamate release

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12 December 2020

Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities.

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12 December 2020

GPR35 is a functional receptor in rat dorsal root ganglion neurons

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12 December 2020

Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway.

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12 December 2020

The aryl hydrocarbon receptor: a perspective on potential roles in the immune system

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12 December 2020

Kynurenine disposition in blood and brain of mice: effects of selective inhibitors of kynurenine hydroxylase and of kynureninase.

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12 December 2020

Neuropharmacology of quinolinic and kynurenic acids

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12 December 2020

Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behavior

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12 December 2020

Curiosity to kill the KAT (kynurenine aminotransferase): structural insights into brain kynurenic acid synthesis

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12 December 2020

Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35

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12 December 2020

Orthologue selectivity and ligand bias: translating the pharmacology of GPR35.

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12 December 2020

High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo.

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12 December 2020

Indolpyruvic acid administration increases the brain content of kynurenic acid. Is this a new avenue to modulate excitatory amino acid receptors in vivo?

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12 December 2020

Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity

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12 December 2020

Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia.

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12 December 2020

Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals

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12 December 2020

Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling

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12 December 2020

Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo

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12 December 2020

Kynurenic acid inhibits the release of the neurotrophic fibroblast growth factor (FGF)-1 and enhances proliferation of glia cells, in vitro

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12 December 2020

Kynurenine administered together with probenecid markedly inhibits pentylenetetrazol-induced seizures. An electrophysiological and behavioural study

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12 December 2020

Identification and quantification of kynurenic acid in human brain tissue.

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12 December 2020

Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype

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12 December 2020

Tryptophan metabolism and brain function: focus on kynurenine and other indole metabolites

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12 December 2020

Cerebral synthesis and release of kynurenic acid: an endogenous antagonist of excitatory amino acid receptors.

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12 December 2020

The precursor but not the mature form of IL1alpha blocks the release of FGF1 in response to heat shock

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12 December 2020

Presence of Kynurenic Acid in the Mammalian Brain

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12 December 2020

Nicotine-induced excitation of locus coeruleus neurons is blocked by elevated levels of endogenous kynurenic acid

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12 December 2020

Depressor effect of kynurenine and its metabolites in rats

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12 December 2020

Studies on indoleamine 2,3-dioxygenase. I. Superoxide anion as substrate

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12 December 2020

Kynurenic acid is present in the rat brain and its content increases during development and aging processes

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12 December 2020

Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid

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12 December 2020

10.1007/S00702-011-0763-X

Identifiers

DOI

1 reference

26 August 2017

1 reference

PubMed ID

22215208