(Q37974553)

26 August 2017

The adaptive immune system as a fundamental regulator of adipose tissue inflammation and insulin resistance (English)

1 reference

26 August 2017

0 references

1 reference

1 reference

Shawn Winer

1

1 reference

PubMed ID

22231651

26 August 2017

Daniel A Winer

series ordinal

2

1 reference

26 August 2017

10 January 2012

1 reference

Immunology & Cell Biology

26 August 2017

1 reference

26 August 2017

90

1 reference

26 August 2017

8

1 reference

26 August 2017

755-762

1 reference

Childhood obesity, other cardiovascular risk factors, and premature death

26 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Macrophages, inflammation, and insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Obesity is associated with macrophage accumulation in adipose tissue

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Immunohistochemical and ultrastructural localization of leptin and leptin receptor in human white adipose tissue and differentiating human adipose cells in primary culture

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Adipose tissues as an ancestral immune organ: site-specific change in obesity.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

FTY720, a sphingosine-1-phosphate receptor modulator, reverses high-fat diet-induced weight gain, insulin resistance and adipose tissue inflammation in C57BL/6 mice

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Normalization of obesity-associated insulin resistance through immunotherapy

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-gamma in inflammation in human adipose tissue

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Interferon-gamma-induced regulation of peroxisome proliferator-activated receptor gamma and STATs in adipocytes.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Macrophage activation and polarization

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

IL-17 regulates adipogenesis, glucose homeostasis, and obesity

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Interleukin-17 family members and inflammation

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

State of the union between metabolism and the immune system in type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Obesity predisposes to Th17 bias

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Mice lacking NKT cells but with a complete complement of CD8+ T-cells are not protected against the metabolic abnormalities of diet-induced obesity

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Visceral adipose inflammation in obesity is associated with critical alterations in tregulatory cell numbers

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Inflammation correlates with markers of T-cell subsets including regulatory T cells in adipose tissue from obese patients

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Regulatory T cell plasticity: beyond the controversies.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Interleukin-10 is a protective factor against diet-induced insulin resistance in liver

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

An essential role of the transcription factor GATA-3 for the function of regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytes.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

CD40L Deficiency Ameliorates Adipose Tissue Inflammation and Metabolic Manifestations of Obesity in Mice

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Peripheral B cell subsets

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

A case for regulatory B cells

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Autoantibodies to glial fibrillary acid protein and S100β in diabetic patients

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Autoimmune islet destruction in spontaneous type 1 diabetes is not beta-cell exclusive.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Associations between autoantibodies against apolipoprotein B-100 peptides and vascular complications in patients with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Autoantibodies in type 2 diabetes induce stress fiber formation and apoptosis in endothelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Sera from patients with type 2 diabetes contain agonistic autoantibodies against G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Post-streptococcal auto-antibodies inhibit protein disulfide isomerase and are associated with insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Clinical and laboratory aspects of Ro/SSA-52 autoantibodies

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Toll-like receptors regulate B cell cytokine production in patients with diabetes

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

A crucial role for adipose tissue p53 in the regulation of insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Dynamics of fat cell turnover in humans

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Adipocyte death, adipose tissue remodeling, and obesity complications

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated Fatty acid/toll-like receptor 4 signaling and macrophage activation in obese adipose tissue

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

TLR4 links innate immunity and fatty acid-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Inflammasome is a central player in the induction of obesity and insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Deficiency for costimulatory receptor 4-1BB protects against obesity-induced inflammation and metabolic disorders

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Bariatric surgery reduces visceral adipose inflammation and improves endothelial function in type 2 diabetic mice

1 reference

https://api.crossref.org/works/10.1038%2FICB.2011.110

7 January 2021

Identifiers

DOI

10.1038/ICB.2011.110

1 reference

26 August 2017

1 reference

PubMed ID

22231651