(Q37978125)

26 August 2017

Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms (English)

1 reference

26 August 2017

Zhao-Li Zhou

1

1 reference

26 August 2017

Ya-Xi Yang

2

1 reference

26 August 2017

Jian Ding

3

1 reference

26 August 2017

Yuan-Chao Li

4

1 reference

26 August 2017

Ze-Hong Miao

5

1 reference

26 August 2017

language of work or name

1 reference

23 January 2012

1 reference

26 August 2017

Natural Product Reports

1 reference

26 August 2017

29

1 reference

26 August 2017

4

1 reference

26 August 2017

457-475

1 reference

Report of 12 cases of ankylosing spondylitis patients treated with Tripterygium wilfordii

26 August 2017

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

The Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide and its expanding multiple pharmacological functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Total synthesis of novel D-ring-modified triptolide analogues: structure-cytotoxic activity relationship studies on the D-ring of triptolide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Design, synthesis, and biological evaluation of novel water-soluble triptolide derivatives: Antineoplastic activity against imatinib-resistant CML cells bearing T315I mutant Bcr-Abl

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide-induced transcriptional arrest is associated with changes in nuclear substructure

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide, a novel diterpenoid triepoxide from Tripterygium wilfordii Hook. f., suppresses the production and gene expression of pro-matrix metalloproteinases 1 and 3 and augments those of tissue inhibitors of metalloproteinases 1 and 2 in human sy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Determination of triptolide in root extracts of Tripterygium wilfordii by solid-phase extraction and reverse-phase high-performance liquid chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Formal total synthesis of triptolide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Diastereoselective formal total synthesis of (+/-)-triptolide via a novel cationic cyclization of 2-alkenyl-1,3-dithiolane

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Natural products to drugs: natural product derived compounds in clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Fluorination of triptolide and its analogues and their cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Design and synthesis of novel C14-hydroxyl substituted triptolide derivatives as potential selective antitumor agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Synthesis and biological evaluation of novel triptolide analogues for anticancer activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

(5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide derivative, prevents experimental autoimmune encephalomyelitis via inhibiting T cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

RNA polymerase - an important molecular target of triptolide in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Enhanced antitumor effect of combined triptolide and ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide augments the effects of 5-lipoxygenase RNA interference in suppressing pancreatic tumor growth in a xenograft mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Antitumor activity of triptolide against cholangiocarcinoma growth in vitro and in hamsters

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Synergistic effect of triptolide combined with 5-fluorouracil on colon carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Role of triptolide as an adjunct chemotherapy for ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

PG490-mediated sensitization of lung cancer cells to Apo2L/TRAIL-induced apoptosis requires activation of ERK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide and TRAIL combination enhances apoptosis in cholangiocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide and chemotherapy cooperate in tumor cell apoptosis. A role for the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Anti-angiogenic activity of triptolide in anaplastic thyroid carcinoma is mediated by targeting vascular endothelial and tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Antiangiogenic activity of Tripterygium wilfordii and its terpenoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

A small-molecule triptolide suppresses angiogenesis and invasion of human anaplastic thyroid carcinoma cells via down-regulation of the nuclear factor-kappa B pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide inhibits Jak2 transcription and induces apoptosis in human myeloproliferative disorder cells bearing Jak2V617F through caspase-3-mediated cleavage of Mcl-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide induces Bcl-2 cleavage and mitochondria dependent apoptosis in p53-deficient HL-60 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Effects of triptolide from Tripterygium wilfordii on ERalpha and p53 expression in two human breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Novel target genes responsive to the anti-growth activity of triptolide in endometrial and ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide alters histone H3K9 and H3K27 methylation state and induces G0/G1 arrest and caspase-dependent apoptosis in multiple myeloma in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Role of triptolide in cell proliferation, cell cycle arrest, apoptosis and histone methylation in multiple myeloma U266 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Chinese herbs as immunomodulators and potential disease-modifying antirheumatic drugs in autoimmune disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Meta-analysis of Tripterygium wilfordii Hook F in the immunosuppressive treatment of IgA nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

The suppressive effect of triptolide on experimental autoimmune uveoretinitis by down-regulating Th1-type response

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide promotes spinal cord repair by inhibiting astrogliosis and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide inhibits the differentiation of Th17 cells and suppresses collagen-induced arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide ameliorates IL-10-deficient mice colitis by mechanisms involving suppression of IL-6/STAT3 signaling pathway and down-regulation of IL-17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

The suppressive effect of triptolide on chronic colitis and TNF-alpha/TNFR2 signal pathway in interleukin-10 deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide reduces proteinuria in experimental membranous nephropathy and protects against C5b-9-induced podocyte injury in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Effective therapy for nephritis in (NZB x NZW)F1 mice with triptolide and tripdiolide, the principal active components of the Chinese herbal remedy Tripterygium wilfordii Hook F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-kappaB/IkappaBalpha transcriptional complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Synergistic effect of triptolide and tacrolimus on rat cardiac allotransplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Immunosuppression of triptolide and its effect on skin allograft survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Immunosuppressive activity of the Chinese medicinal plant Tripterygium wilfordii. I. Prolongation of rat cardiac and renal allograft survival by the PG27 extract and immunosuppressive synergy in combination therapy with cyclosporine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

A potential new treatment for rheumatoid arthritis: thunder god vine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide attenuates endotoxin- and staphylococcal exotoxin-induced T-cell proliferation and production of cytokines and chemokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Alternative activation of macrophages: immune function and cellular biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Complexity of dendritic cell subsets and their function in the host immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide suppresses CD80 and CD86 expressions and IL-12 production in THP-1 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Prolongation of rat intestinal allograft survival by administration of triptolide-modified donor bone marrow-derived dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide affects the differentiation, maturation and function of human dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Inhibitory effect of triptolide on interleukin-18 and its receptor in rheumatoid arthritis synovial fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide suppresses proinflammatory cytokine-induced matrix metalloproteinase and aggrecanase-1 gene expression in chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Effects of triptolide from Radix Tripterygium wilfordii (Leigongteng) on cartilage cytokines and transcription factor NF-kappaB: a study on induced arthritis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Recent progress in research on Tripterygium: a male antifertility plant

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide reduces cystogenesis in a model of ADPKD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

(5R)-5-hydroxytriptolide attenuated collagen-induced arthritis in DBA/1 mice via suppressing interferon-gamma production and its related signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Preventive effects of (5R)-5-hydroxytriptolide on concanavalin A-induced hepatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

(5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide analog mediates immunosuppressive effects in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Differential effects of triptolide and tetrandrine on activation of COX-2, NF-kappaB, and AP-1 and virus production in dengue virus-infected human lung cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide modulates T-cell inflammatory responses and ameliorates experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

XPB, a subunit of TFIIH, is a target of the natural product triptolide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Effects of triptolide on RIZ1 expression, proliferation, and apoptosis in multiple myeloma U266 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosis-reluctant cells to tumor necrosis factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Molecular understanding and modern application of traditional medicines: triumphs and trials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Triptolide directly inhibits dCTP pyrophosphatase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

Studies on calcium dependence reveal multiple modes of action for triptolide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2NP00088A

21 January 2018

Identifiers

DOI

10.1039/C2NP00088A

1 reference

26 August 2017

1 reference