(Q36755350)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21278739%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

title

XPB, a subunit of TFIIH, is a target of the natural product triptolide (English)

1 reference

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21 January 2020

1 reference

1

1 reference

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21 January 2020

Woon-Kai Low

5

1 reference

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21 January 2020

Yongjun Dang

6

1 reference

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21 January 2020

author name string

Benjamin Gilman

2

1 reference

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21 January 2020

Qing-Li He

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21278739%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Shridhar Bhat

4

1 reference

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21 January 2020

Michael Smeaton

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21278739%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Arnold L Demain

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21278739%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Paul S Miller

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21278739%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Jennifer F Kugel

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21278739%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

James A Goodrich

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21278739%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Jun O Liu

12

1 reference

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21 January 2020

publication date

30 January 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21278739%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

published in

Nature Chemical Biology

1 reference

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21 January 2020

volume

7

1 reference

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21 January 2020

issue

3

1 reference

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21 January 2020

page(s)

182-188

1 reference

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RNA polymerase - an important molecular target of triptolide in cancer cells

21 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Design and synthesis of novel C14-hydroxyl substituted triptolide derivatives as potential selective antitumor agents

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Triptolide-induced transcriptional arrest is associated with changes in nuclear substructure

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

End modification of a linear DNA duplex enhances NER-mediated excision of an internal Pt(II)-lesion

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Cancer-specific enhancement of cisplatin-induced cytotoxicity with triptolide through an interaction of inactivated glycogen synthase kinase-3beta with p53.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Fluorination of triptolide and its analogues and their cytotoxicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Small-scale extracts for the study of nucleotide excision repair and non-homologous end joining

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Triptolide binds covalently to a 90 kDa nuclear protein. Role of epoxides in binding and activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

An 8 nt RNA triggers a rate-limiting shift of RNA polymerase II complexes into elongation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Semisynthesis of C-ring modified triptolide analogues and their cytotoxic activities

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Inhibition of eukaryotic translation initiation by the marine natural product pateamine A.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Ubiquitin ligase activity of TFIIH and the transcriptional response to DNA damage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

The evolving role of natural products in drug discovery

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Cytotoxic Biotransformed Products from Triptonide byAspergillus niger

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Translocation after synthesis of a four-nucleotide RNA commits RNA polymerase II to promoter escape

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Triptolide and chemotherapy cooperate in tumor cell apoptosis. A role for the p53 pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Flavopiridol inhibits P-TEFb and blocks HIV-1 replication

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Mechanism of ATP-dependent promoter melting by transcription factor IIH

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor

29 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

29 September 2017

https://api.crossref.org/works/10.1038%2FNCHEMBIO.522

The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Transcription factors IIE and IIH and ATP hydrolysis direct promoter clearance by RNA polymerase II

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Identification of thein vivoandin vitroorigin of transcription in human rDNA

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Specificity of RNA maturation pathways: RNAs transcribed by RNA polymerase III are not substrates for splicing or polyadenylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

An RNA polymerase II transcription factor has an associated DNA-dependent ATPase (dATPase) activity strongly stimulated by the TATA region of promoters

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

TATA-binding protein and transcription factor IIB induce transcript slipping during early transcription by RNA polymerase II.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Casein kinase type II is involved in the inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcription

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Immunosuppression of triptolide and its effect on skin allograft survival

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

RNA polymerase II and TAFs undergo a slow isomerization after the polymerase is recruited to promoter-bound TFIID.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Effect of actinomycin D on cellular nucleic acid synthesis and virus production

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622543

Tumor inhibitors. LXXIV. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii

5 September 2018

1 reference

12 December 2020

Preparation of HeLa nuclear extracts

1 reference

12 December 2020

Immunoaffinity purification of the human multisubunit transcription factor IIH

1 reference

12 December 2020

Inhibition of type II collagen-induced arthritis in rats by triptolide

1 reference

12 December 2020

Specific Inhibition of Nuclear RNA Polymerase II by α-Amanitin

1 reference

12 December 2020

Selective alkylation: a biomimetic reaction of the antileukemic triptolides?

1 reference

12 December 2020

Action of membrane-active compounds on mammalian cells. Permeabilization of human cells by ionophores to inhibitors of translation and transcription

1 reference

12 December 2020

Studies of in vitro transcription by calf thymus RNA polymerase II using a novel duplex DNA template

1 reference

12 December 2020

Phase I dose-escalation study of F60008, a novel apoptosis inducer, in patients with advanced solid tumours

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.522

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21278739%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21278739%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

PubMed publication ID

21278739

1 reference