(Q37978237)

26 August 2017

title

Role of T cells in ovariectomy induced bone loss--revisited (English)

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26 August 2017

Roberto Pacifici

1

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26 August 2017

publication date

1 February 2012

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Journal of Bone and Mineral Research

26 August 2017

published in

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26 August 2017

volume

27

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26 August 2017

issue

2

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26 August 2017

page(s)

231-239

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Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha

26 August 2017

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Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts

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The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone

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Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo

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Estrogen prevents bone loss through transforming growth factor beta signaling in T cells

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IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation

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Ovariectomy disregulates osteoblast and osteoclast formation through the T-cell receptor CD40 ligand

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Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation

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T lymphocyte-deficient mice lose trabecular bone mass with ovariectomy.

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Lymphocytes and the Dap12 adaptor are key regulators of osteoclast activation associated with gonadal failure

21 January 2018

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IL-7 drives T cell-mediated bone loss following ovariectomy.

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Cutting edge: estrogen drives expansion of the CD4+CD25+ regulatory T cell compartment

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Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

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Estrogen receptor α signaling in T lymphocytes is required for estradiol-mediated inhibition of Th1 and Th17 cell differentiation and protection against experimental autoimmune encephalomyelitis.

21 January 2018

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A bone-protective role for IL-17 receptor signaling in ovariectomy-induced bone loss

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Human CD4+CD25+ regulatory T cells inhibit the differentiation of osteoclasts from peripheral blood mononuclear cells

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Estrogen enhances the functions of CD4(+)CD25(+)Foxp3(+) regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro

21 January 2018

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Increased bone density and resistance to ovariectomy-induced bone loss in FoxP3-transgenic mice based on impaired osteoclast differentiation

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Homeostasis of naive and memory T cells

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The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery

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Human nutrition, the gut microbiome and the immune system

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Daidzein prevents the increase in CD4+CD28null T cells and B lymphopoesis in ovariectomized mice: a key mechanism for anti-osteoclastogenic effect

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Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: a key mechanism in osteoporosis.

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Role of RANK ligand in mediating increased bone resorption in early postmenopausal women

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Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency

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Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II transactivator.

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Generation of functional thymocytes in the human adult.

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Evidence for estradiol-induced apoptosis and dysregulated T cell maturation in the thymus

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Augmentation of T Cell Levels and Responses Induced by Androgen Deprivation

21 January 2018

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Activation of thymic regeneration in mice and humans following androgen blockade

21 January 2018

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An IL-7-dependent rebound in thymic T cell output contributes to the bone loss induced by estrogen deficiency.

21 January 2018

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A crucial role for thiol antioxidants in estrogen-deficiency bone loss

21 January 2018

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Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats.

21 January 2018

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21 January 2018

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21 January 2018

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Oxidant signals and oxidative stress

21 January 2018

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Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids

21 January 2018

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Redox imbalance induced by contact sensitizers triggers the maturation of dendritic cells

21 January 2018

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Reactive oxygen species are essential mediators in antigen presentation by Kupffer cells

21 January 2018

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Dendritic cells exposed to nacystelyn are refractory to maturation and promote the emergence of alloreactive regulatory t cells

21 January 2018

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Tumor necrosis factor-alpha mediates osteopenia caused by depletion of antioxidants

21 January 2018

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Transcriptional regulation of the MHC class II antigen presentation pathway

21 January 2018

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Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors

21 January 2018

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Long-term treatment of osteopetrosis with recombinant human interferon gamma

21 January 2018

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Interferon-γ plays a role in bone formation in vivo and rescues osteoporosis in ovariectomized mice.

21 January 2018

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Signaling crosstalk between RANKL and interferons in osteoclast differentiation

21 January 2018

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Autocrine regulation of interferon gamma in mesenchymal stem cells plays a role in early osteoblastogenesis

21 January 2018

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Increased B-lymphopoiesis by interleukin 7 induces bone loss in mice with intact ovarian function: similarity to estrogen deficiency

21 January 2018

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Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency

21 January 2018

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IL-7 inhibits fibroblast TGF-beta production and signaling in pulmonary fibrosis

21 January 2018

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Down-regulation of murine fibrosarcoma transforming growth factor-beta 1 expression by interleukin 7.

21 January 2018

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CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

21 January 2018

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CD40/CD154 interactions at the interface of tolerance and immunity

21 January 2018

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CD40 ligand binds to alpha5beta1 integrin and triggers cell signaling

21 January 2018

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CD40 Ligand Blocks Apoptosis Induced by Tumor Necrosis Factor α, Glucocorticoids, and Etoposide in Osteoblasts and the Osteocyte-Like Cell Line Murine Long Bone Osteocyte-Y4

21 January 2018

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B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo

21 January 2018

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Osteopenia in X-linked hyper-IgM syndrome reveals a regulatory role for CD40 ligand in osteoclastogenesis.

21 January 2018

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T cells potentiate PTH-induced cortical bone loss through CD40L signaling

21 January 2018

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Dlk1/FA1 is a novel endocrine regulator of bone and fat mass and its serum level is modulated by growth hormone.

21 January 2018

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dlk1/FA1 regulates the function of human bone marrow mesenchymal stem cells by modulating gene expression of pro-inflammatory cytokines and immune response-related factors

21 January 2018

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DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice.

21 January 2018

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The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development

21 January 2018

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Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform

21 January 2018

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RANKL and RANK in sex hormone-induced breast cancer and breast cancer metastasis

21 January 2018

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T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JBMR.1500

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26 August 2017

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