(Q37980010)

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An environmental analysis of genes associated with schizophrenia: hypoxia and vascular factors as interacting elements in the neurodevelopmental model.

scientific article published on 31 January 2012

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21 January 2020

An environmental analysis of genes associated with schizophrenia: hypoxia and vascular factors as interacting elements in the neurodevelopmental model (English)

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21 January 2020

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21 January 2020

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21 January 2020

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R Schmidt-Kastner

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21 January 2020

G Esquivel

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21 January 2020

H W M Steinbusch

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21 January 2020

Molecular Psychiatry

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21 January 2020

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21 January 2020

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21 January 2020

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21 January 2020

https://scigraph.springernature.com/pub.10.1038/mp.2011.183

0 references

Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

1 reference

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Schizophrenia as a disorder of neurodevelopment

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A developmental model for similarities and dissimilarities between schizophrenia and bipolar disorder

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The environment and schizophrenia

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Time between schizophrenia onset and first request for disability status in France and associated patient characteristics

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Are psychotic psychopathology and neurocognition orthogonal? A systematic review of their associations

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21 January 2018

The molecular genetics of schizophrenia: new findings promise new insights

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Finding schizophrenia genes

1 reference

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Schizophrenia susceptibility genes: emergence of positional candidates and future directions

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Obstetric conditions and risk of first admission with schizophrenia: a Danish national register based study

1 reference

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Obstetric complications and schizophrenia: historical and meta-analytic review

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Risk for schizophrenia--broadening the concepts, pushing back the boundaries

1 reference

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Gene-environment interaction and covariation in schizophrenia: the role of obstetric complications

1 reference

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21 January 2018

Hypoxic-ischemia-related fetal/neonatal complications and risk of schizophrenia and other nonaffective psychoses: a 19-year longitudinal study

1 reference

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21 January 2018

Association of measures of fetal and childhood growth with non-clinical psychotic symptoms in 12-year-olds: the ALSPAC cohort.

1 reference

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21 January 2018

Investigating whether adverse prenatal and perinatal events are associated with non-clinical psychotic symptoms at age 12 years in the ALSPAC birth cohort.

1 reference

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21 January 2018

Obstetrical complications in people at risk for developing schizophrenia

1 reference

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21 January 2018

Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: a possible signal for vessel development

1 reference

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21 January 2018

Oxygen, genes, and development: an analysis of the role of hypoxic gene regulation during murine vascular development.

1 reference

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21 January 2018

A new notch in the HIF belt: how hypoxia impacts differentiation.

1 reference

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21 January 2018

Hypoxic stress in diabetic pregnancy contributes to impaired embryo gene expression and defective development by inducing oxidative stress.

1 reference

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21 January 2018

HIF-1 and mechanisms of hypoxia sensing

1 reference

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21 January 2018

Hypoxia-regulated differentiation: let's step it up a Notch

1 reference

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21 January 2018

Different networks, common growth factors: shared growth factors and receptors of the vascular and the nervous system

1 reference

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21 January 2018

Gene regulation by hypoxia and the neurodevelopmental origin of schizophrenia

1 reference

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21 January 2018

Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database

1 reference

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21 January 2018

DNA microarray analysis of cortical gene expression during early recirculation after focal brain ischemia in rat.

1 reference

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21 January 2018

Hypoxia-inducible factor 1 (HIF-1) pathway

1 reference

https://api.crossref.org/works/10.1038%2FMP.2011.183

21 January 2018

Integration of oxygen signaling at the consensus HRE.

1 reference

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21 January 2018

Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage.

1 reference

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21 January 2018

Identification of potential stroke targets by lentiviral vector mediated overexpression of HIF-1 alpha and HIF-2 alpha in a primary neuronal model of hypoxia

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21 January 2018

AKT1 Gene Polymorphisms and Obstetric Complications in the Patients with Schizophrenia

1 reference

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21 January 2018

Serious obstetric complications interact with hypoxia-regulated/vascular-expression genes to influence schizophrenia risk.

1 reference

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21 January 2018

Decreased neurotrophic response to birth hypoxia in the etiology of schizophrenia.

1 reference

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21 January 2018

Role of non-neuronal nicotinic acetylcholine receptors in angiogenesis

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Immunohistochemical detection of dysbindin at the astroglial endfeet around the capillaries of mouse brain.

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MLC1 is associated with the dystrophin-glycoprotein complex at astrocytic endfeet

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21 January 2018

Genome-wide association study of schizophrenia in a Japanese population

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Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations.

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21 January 2018

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.

1 reference

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21 January 2018

Oxygen restriction of neonate rats elevates neuregulin-1alpha isoform levels: possible relationship to schizophrenia

1 reference

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21 January 2018

Neuregulin-1, the fetal endothelium, and brain damage in preterm newborns

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Early neurological phenotype in 4 children with biallelic PRODH mutations

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Impaired migration signaling in the hippocampus following prenatal hypoxia.

1 reference

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21 January 2018

Reelin-deficient mice show impaired neurogenesis and increased stroke size

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Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells

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Nogo Receptor 1 (RTN4R) as a candidate gene for schizophrenia: analysis using human and mouse genetic approaches

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21 January 2018

Enhanced neurogenesis in the ischemic striatum following EGF-induced expansion of transit-amplifying cells in the subventricular zone.

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21 January 2018

DAVID: Database for Annotation, Visualization, and Integrated Discovery

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

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21 January 2018

A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia

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21 January 2018

The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients

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Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha.

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21 January 2018

Translocation and down-regulation of protein kinase C-alpha, -beta, and -gamma isoforms during ischemia-reperfusion in rat brain.

1 reference

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Family-based association study of SELENBP1 in schizophrenia.

1 reference

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21 January 2018

Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia

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21 January 2018

Hypoxia-inducible factor-1alpha suppresses squamous carcinogenic progression and epithelial-mesenchymal transition

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Association of genetic variation in the MET proto-oncogene with schizophrenia and general cognitive ability

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21 January 2018

Post-ischemic delayed expression of hepatocyte growth factor and c-Met in mouse brain following focal cerebral ischemia

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Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia

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Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women

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Genomewide association for schizophrenia in the CATIE study: results of stage 1

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A genome-wide association study in 574 schizophrenia trios using DNA pooling

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Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk

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Identification of loci associated with schizophrenia by genome-wide association and follow-up

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Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2.

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A genome-wide investigation of SNPs and CNVs in schizophrenia

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GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia

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Strong synaptic transmission impact by copy number variations in schizophrenia

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Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression

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Interacting haplotypes at the NPAS3 locus alter risk of schizophrenia and bipolar disorder

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Understanding the role of DISC1 in psychiatric disease and during normal development

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Sequencing of 50 human exomes reveals adaptation to high altitude

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Genetic evidence for high-altitude adaptation in Tibet

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Copy-number variations associated with neuropsychiatric conditions

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Copy-number variants in neurodevelopmental disorders: promises and challenges

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Rare structural variants in schizophrenia: one disorder, multiple mutations; one mutation, multiple disorders

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Copy number variations in schizophrenia: critical review and new perspectives on concepts of genetics and disease

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Large recurrent microdeletions associated with schizophrenia

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Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia

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Rare chromosomal deletions and duplications increase risk of schizophrenia

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21 January 2018

Recurrent CNVs disrupt three candidate genes in schizophrenia patients

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21 January 2018

Support for the involvement of large copy number variants in the pathogenesis of schizophrenia

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21 January 2018

Copy number variation in schizophrenia in the Japanese population

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21 January 2018

New copy number variations in schizophrenia.

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21 January 2018

Copy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications

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Epigenetics, the epicenter of the hypoxic response

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Role of hypoxia-inducible factors in epigenetic regulation via histone demethylases

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Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

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Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells

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Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha

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The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF.

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Epigenetic mediation of environmental influences in major psychotic disorders

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Induction of DNA hypomethylation by tumor hypoxia.

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Epigenomic profiling reveals DNA-methylation changes associated with major psychosis

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Hypoxia response and microRNAs: no longer two separate worlds.

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Upregulation of dicer and microRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia.

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Genome-wide association study identifies five new schizophrenia loci

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Temporal differences in microRNA expression patterns in astrocytes and neurons after ischemic injury

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Fetal hypoxia and structural brain abnormalities in schizophrenic patients, their siblings, and controls.

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Effects of brain-derived neurotrophic factor Val66Met polymorphism on hippocampal volume change in schizophrenia

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Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls.

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DTNBP1 is associated with imaging phenotypes in schizophrenia

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Neuregulin 1 (8p12) and childhood-onset schizophrenia: susceptibility haplotypes for diagnosis and brain developmental trajectories.

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No effect of obstetric complications on basal ganglia volumes in schizophrenia

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Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia

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Cytokine and growth factor involvement in schizophrenia--support for the developmental model

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Gene expression and genetic variation in response to endoplasmic reticulum stress in human cells

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A population genetic approach to mapping neurological disorder genes using deep resequencing

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Modelling schizophrenia using human induced pluripotent stem cells

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An exploratory model for G×E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes

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Microarray analysis of acute and delayed gene expression profile in rats after focal ischemic brain injury and reperfusion

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Cerebral cortical thickness and a history of obstetric complications in schizophrenia

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Obstetric complications as a risk factor for first psychotic episodes in childhood and adolescence

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Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor

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Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

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based on heuristic

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Common variants on chromosome 6p22.1 are associated with schizophrenia

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7 January 2021

based on heuristic

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Common variants conferring risk of schizophrenia

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Association of NPAS3 exonic variation with schizophrenia

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https://api.crossref.org/works/10.1038%2FMP.2011.183

7 January 2021

based on heuristic

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DNA methyltransferase contributes to delayed ischemic brain injury.

1 reference

https://api.crossref.org/works/10.1038%2FMP.2011.183

7 January 2021

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Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia.

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7 January 2021

based on heuristic

inferred from DOI database lookup

Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain

1 reference

https://api.crossref.org/works/10.1038%2FMP.2011.183

7 January 2021

based on heuristic

inferred from DOI database lookup

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